Q46WD5

PR
Gene name
rpoC
Protein name
DNA-directed RNA polymerase subunit beta'
Names
RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'
Species
Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Cupriavidus necator (strain JMP 134))
KEGG Pathway
reu:Reut_A3188
EC number
2.7.7.6: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1363-1415 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q46WD5

Entry ID Method Resolution Chain Position Source
AF-Q46WD5-F1 Predicted AlphaFoldDB

No variants for Q46WD5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q46WD5

No associated diseases with Q46WD5

6 regional properties for Q46WD5

Type Name Position InterPro Accession
domain RNA polymerase, alpha subunit 345 - 486 IPR000722
domain RNA polymerase, N-terminal 236 - 515 IPR006592
domain RNA polymerase Rpb1, domain 3 490 - 650 IPR007066
domain RNA polymerase Rpb1, domain 1 15 - 343 IPR007080
domain RNA polymerase Rpb1, domain 5 772 - 1322 IPR007081
domain RNA polymerase Rpb1, domain 4 679 - 769 IPR007083

Functions

Description
EC Number 2.7.7.6 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
DNA-directed RNA polymerase complex A protein complex that possesses DNA-directed RNA polymerase activity.

4 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
magnesium ion binding Binding to a magnesium (Mg) ion.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
DNA-templated transcription The synthesis of an RNA transcript from a DNA template.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKALLDLFKQ VQQEEQFDAI KIGLASPEKI RSWSYGEVKK PETINYRTFK PERDGLFCAK
70 80 90 100 110 120
IFGPIKDYEC LCGKYKRLKH RGVICEKCGV EVTLAKVRRE RMGHIELAAP TAHIWFLKSL
130 140 150 160 170 180
PSRLGMVLDM TLRDIERVLY FEAFVVLEPG MTPLKKSQIM SEDDYLAKCD EYGEGEFVAM
190 200 210 220 230 240
MGAEGIRELL RGIDIEKQIE QIRAELQATG SEAKIKKFAK RLKVLEAFQR SGIKPEWMIL
250 260 270 280 290 300
EVLPVLPPEL RPLVPLDGGR FATSDLNDLY RRVINRNNRL KRLLELKAPE IIVRNEKRML
310 320 330 340 350 360
QEAVDSLLDN GRRGKAMTGA NKRPLKSLAE MIKGKGGRFR QNLLGKRVDY SGRSVIVVGP
370 380 390 400 410 420
TLKLHQCGLP KLMALELFKP FIFHKLETMG IATTIKAAKK EVESQTPVVW DILEEVIREH
430 440 450 460 470 480
PVMLNRAPTL HRLGIQAFEP VLIEGKAIQL HPLVCAAFNA DFDGDQMAVH VPLSLEAQME
490 500 510 520 530 540
ARTLMLASNN VLFPANGDPS IVPSQDVVLG LYYTTRDKIN GKGEGMTFAD ISEVIRAYEN
550 560 570 580 590 600
KEVELASRVN VRITEYELVD KDAEGDARFA PKITLQATTV GRAILSEILP KGLPFSVLNK
610 620 630 640 650 660
PLKKKEISRL INTAFRKCGL RETVIFADKL LQSGFRLATR AGISIAIDDM LVPPAKEKII
670 680 690 700 710 720
SEASAKVKEY DKQYMSGLVT DQERYNNVVD IWGAAGDQVG KAMMEQLQHE DVVDRNGNTV
730 740 750 760 770 780
KQESFNSIYM MADSGARGSA AQIRQLAGMR GLMAKPDGSI IETPITANFR EGLNVLQYFI
790 800 810 820 830 840
STHGARKGLA DTALKTANSG YLTRRLVDVT QDLVVVEDDC GTSNGVAMKA LVEGGEVIEA
850 860 870 880 890 900
LRDRILGRVT VADVVNPETQ ETAIETGTLL DEDLVDLIDA LGVDEVKVRT PLSCDTRYGL
910 920 930 940 950 960
CGKCYGRDLG RGVLVNSGEA VGVIAAQSIG EPGTQLTMRT FHIGGAASRA AVASSVEAKA
970 980 990 1000 1010 1020
TGTVRFTVTM RYVTNAKGEL IVISRSGEAL ITDDHGRERE RHKIPYGATL LVQDGQAIKA
1030 1040 1050 1060 1070 1080
GTQLATWDAL TRPIVSEYTG TTKFENVEEG VTVAKQMDEV TGLSTLVVID AKRRTAATKG
1090 1100 1110 1120 1130 1140
IRPQVKLLDA NGQEVKIPGT DHSVTIGFQV GALITVKDGQ QVHVGEVLAR IPTESQKTRD
1150 1160 1170 1180 1190 1200
ITGGLPRVAE LFEARSPKDA AVLAEVTGTT SFGKDTKGKQ RLVITDLDGN AHEFLIAKEK
1210 1220 1230 1240 1250 1260
QVLVHDGQVV NKGEMIVEGP ADPHDILRLK GIEELAHYIV DEVQDVYRLQ GVKINDKHIE
1270 1280 1290 1300 1310 1320
VIVRQMLRRV QVADVGDTKF IPGEQVERSE LLDENDRVIA EGKRPATYEN LLLGITKASL
1330 1340 1350 1360 1370 1380
STDSFISAAS FQETTRVLTE AAIMGKTDDL RGLKENVIVG RLIPAGTGLA YHRARKAREA
1390 1400 1410
SERERAQAIA DEEQSLFIEP PPVVQATTEG EGDNA