Q46L15

PR
Gene name
leuS
Protein name
Leucine--tRNA ligase
Names
Leucyl-tRNA synthetase, LeuRS
Species
Prochlorococcus marinus (strain NATL2A)
KEGG Pathway
pmn:PMN2A_0321
EC number
6.1.1.4: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

265-334 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q46L15

Entry ID Method Resolution Chain Position Source
AF-Q46L15-F1 Predicted AlphaFoldDB

No variants for Q46L15

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q46L15

No associated diseases with Q46L15

6 regional properties for Q46L15

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 51 - 62 IPR001412
domain Aminoacyl-tRNA synthetase, class Ia 429 - 586 IPR002300-1
domain Aminoacyl-tRNA synthetase, class Ia 624 - 664 IPR002300-2
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 704 - 825 IPR013155
domain Methionyl/Leucyl tRNA synthetase 49 - 182 IPR015413
domain Leucyl-tRNA synthetase, editing domain 231 - 413 IPR025709

Functions

Description
EC Number 6.1.1.4 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
leucine-tRNA ligase activity Catalysis of the reaction: L-leucine + ATP + tRNA(Leu) = AMP + diphosphate + 2 H(+) + Leu-tRNA(Leu).

1 GO annotations of biological process

Name Definition
leucyl-tRNA aminoacylation The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. The leucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a leucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNNTTSDIND QRYEPREVEA YWQKEWASDD LYRTNTEVNK ENTFYALSMF PYPSGSLHMG
70 80 90 100 110 120
HVRNYVITDV LARYKRMKGF NVLHPMGWDS FGLPAENAAI EREISPSTWT DKNISQMKDQ
130 140 150 160 170 180
LDRLGLSIDW SKEVTTCKEE YYKWTQYIFN QLHKNNLAYQ KKATVNWDPI DQTVLANEQV
190 200 210 220 230 240
DAEGKSWRSG AKVEKKELNQ WFLRITSFAE DLNKDLIKLN DWPDRVRVMQ KNWIGKSIGA
250 260 270 280 290 300
EITFEIKNSD QKITAFTTRI DTVYGVSYLV LASNHPLIDQ LISSNDIDKL NDFRQTQEKL
310 320 330 340 350 360
SDLERNSDTR QKLGMYLGVD AINPANNKEI PIWIGDYVIM EYGTGAVMGV PAHDSRDYQF
370 380 390 400 410 420
AKSYDLPIQY VIKPNIDEDE SYLNAEFVDK GIMINSDKFN GIESDIAKTQ ILEFGSNSNW
430 440 450 460 470 480
AKPKITYKLR DWLISRQRYW GCPIPIINCK KCGQVRVPDN DLPVVLPIDI KLTGKGKSPL
490 500 510 520 530 540
TTKTEWINTC CPKCGTEAKR ETDTMDTFMC SSWYFLRYIN PDNCEKPFLK SEIDKWLPVK
550 560 570 580 590 600
QYVGGIEHAI LHLLYSRFLT KALKKCGLIN IDEPFKKLLT QGMVQAVTFK NPNTNKYFSK
610 620 630 640 650 660
DQIKDIDNPK DPLTGENIEI IYEKMSKSKY NGVDPSVVID KYGADTARMF ILFKAPPEKD
670 680 690 700 710 720
LEWDDSDVEG QYRFIQRLWK FVINTFKLTN NNSRSNIEKE KSKDEEALRL INIAIKEITD
730 740 750 760 770 780
DLDNLQFNTA ISELMKVVNG LSLIVNYCSN ETLNKVISIL VKITSPFSPH IAEELWKTIG
790 800 810 820 830 840
NTQSIHLQSW PEFDAGAIEQ DTFKLMIQIN GKVRGSINAS KNLSKENLED LAIKTEAAIK
850 860
WMDGKEPKRI IVVPNKLVNI VI