Q46F18

PR
Gene name
metG
Protein name
Methionine--tRNA ligase
Names
Methionyl-tRNA synthetase, MetRS
Species
Methanosarcina barkeri (strain Fusaro / DSM 804)
KEGG Pathway
mba:Mbar_A0543
EC number
6.1.1.10: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

515-628 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q46F18

Entry ID Method Resolution Chain Position Source
AF-Q46F18-F1 Predicted AlphaFoldDB

No variants for Q46F18

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q46F18

No associated diseases with Q46F18

7 regional properties for Q46F18

Type Name Position InterPro Accession
domain tRNA-binding domain 608 - 710 IPR002547
domain Methionyl-tRNA synthetase, beta subunit, C-terminal 588 - 710 IPR004495
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 414 - 567 IPR013155
domain Methionyl/Leucyl tRNA synthetase 9 - 396 IPR015413
domain Methioninyl-tRNA synthetase core domain 8 - 371 IPR033911-1
domain Methioninyl-tRNA synthetase core domain 383 - 394 IPR033911-2
domain Methionyl-tRNA synthetase, anticodon-binding domain 380 - 502 IPR041872

Functions

Description
EC Number 6.1.1.10 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
methionine-tRNA ligase activity Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met).
tRNA binding Binding to a transfer RNA.

1 GO annotations of biological process

Name Definition
methionyl-tRNA aminoacylation The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. The methionyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a methionine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPEPSSKPVL VTCGLPYANG KAHIGHLRTY VPADIYARSL RKEGRDVTFV CGSDTHGTPI
70 80 90 100 110 120
VVNAEELGIT PKELVEVYHK HFDETFKQLG VYFDAFGTTD DPENHNRTLD IVNRLIEKGY
130 140 150 160 170 180
VYPKTIEIAY CPKCNRFLPD RYVEGSCPHC GEIARGDECD QGCGKHLEPG ELLNPVCTIC
190 200 210 220 230 240
GGPAEYRQQE HFFFKLSEFS DYLMDYLSND LGGTINARNY ALGWVKQGLT DWCITRNLEW
250 260 270 280 290 300
GVKFPGHDDL VVYVWVDAPI GYIAFTEEWA AKAGDSWEKF WKNDGEIVHF IGGDITYHHC
310 320 330 340 350 360
IFWPAMLKGA DYSVPTAVVA SGMVKIEDKK FSKSRGNVVW VGEDYLSHGF HPDLLRYYLA
370 380 390 400 410 420
SYTSHTKELN FSWRVLQEKI NTELVSVLGN FLYRTMLFAF KNYGEVPSGE LEPEVREEIE
430 440 450 460 470 480
KALKEVKAAM AEYEFKKAVD SAMSLASFGN TYFQSHEPWN LIKQDKAACG QVLYNCLHLA
490 500 510 520 530 540
KALCLIFEPV TPGSMETAWK ELGQEGDLHT TLYADALVPL KAGTKLAKPK ILFTKLEDDR
550 560 570 580 590 600
IEEMEEIANQ RVKAADAKKA AGKGNGKEPT KAEGMGPAEE AKPAEKAGGA AKPREEEKET
610 620 630 640 650 660
LPMIEYEDFA KLDIRVGKVL LAEPVKKSKK LIRIEVDIGE EKTRQLVAGL SSYYAPEELV
670 680 690 700
GKSVIVLANL KPAKLCGVKS NGMMLAADDG GEIVSALMPD KEIKPGSRIR