Q46D71

PR
Gene name
sepS
Protein name
O-phosphoserine--tRNA(Cys) ligase
Names
O-phosphoserine--tRNA ligase, Non-canonical O-phosphoseryl-tRNA(Cys) synthetase, O-phosphoseryl-tRNA(Cys) synthetase, SepRS
Species
Methanosarcina barkeri (strain Fusaro / DSM 804)
KEGG Pathway
mba:Mbar_A1204
EC number
6.1.1.27: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

76-149 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q46D71

Entry ID Method Resolution Chain Position Source
AF-Q46D71-F1 Predicted AlphaFoldDB

No variants for Q46D71

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q46D71

No associated diseases with Q46D71

2 regional properties for Q46D71

Type Name Position InterPro Accession
domain PurM-like, C-terminal domain 193 - 367 IPR010918
domain PurM-like, N-terminal domain 82 - 169 IPR016188

Functions

Description
EC Number 6.1.1.27 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
phosphoserine-tRNA(Cys) ligase activity Catalysis of the reaction: tRNA(Cys) + O-phospho-L-serine + ATP = AMP + diphosphate + phosphoseryl-tRNA(Cys).
tRNA binding Binding to a transfer RNA.

2 GO annotations of biological process

Name Definition
translation The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.
tRNA aminoacylation The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKFDPEKIKR DAKENFDLTW NEGKKLVRTP TLNERYPRTI LKYGKAHPVY DTIQKLREAY
70 80 90 100 110 120
LRMGFEEMMN PLIVDDKEVH KQFGSEALAV LDRCFYLAGL PRPNVGISDE RTAEVKEILG
130 140 150 160 170 180
DIGNDGVEKI RQVLHSYKKG KIEGDDLVPE ISTVLGVSDA LVADMIDKVF PEFKELVPQA
190 200 210 220 230 240
STKTLRSHMT SGWFISLGAL LERQEPPFHF FSVDRCFRRE QQEDASRLMT YYSASCVIMD
250 260 270 280 290 300
EGVTVDHGKA VSEGLLSQFG FEKFLFRPDE KRSKYYIPDT QTEVFAFHPK LVGSNSKYSD
310 320 330 340 350 360
GWIEIATFGI YSPTALAQYD IPCPVMNLGL GVERLAMILH DAPDIRSLTY PQIPQYTEWE
370 380 390 400 410 420
MSDGELAKQV FVDKVPETSE GLAIAASIVS QCELHGEEPS PCEFPSWEGE ICGRKVKVSV
430 440 450 460 470 480
IEPEENTKLC GPAAFNEVVA YQGDIMGIPN TKKWQKAFEN HSARAGIRFI EAFAAQAARE
490 500 510 520 530
IEEAALSGAT EHIVRIRIAK VPSEVNLRIG SIAQRYVTGK KKKIDMRGPV FTSVKAEFV