Q46CS0

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Methanosarcina barkeri (strain Fusaro / DSM 804)
KEGG Pathway
mba:Mbar_A1361
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

860-923 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q46CS0

Entry ID Method Resolution Chain Position Source
AF-Q46CS0-F1 Predicted AlphaFoldDB

No variants for Q46CS0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q46CS0

No associated diseases with Q46CS0

4 regional properties for Q46CS0

Type Name Position InterPro Accession
domain DHHA1 domain 781 - 913 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 702 - 744 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 62 - 603 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 58 - 757 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

5 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLEDEYQLEF FKNNGFVRKQ CQSCGKFFWT RDLDRKTCGD APCDPYTFIG NPIFSREFDI
70 80 90 100 110 120
SQMREYYLSF FEEKGHTRIN RYPVVARWRD DLYLTIASIA DFQPFVTSGQ VPPPANPLTI
130 140 150 160 170 180
SQPCIRLNDL DSVGRSGRHL TTFEMMAHHA FNKRDHEIYW KEHAMELCDE LLTSLKLDPL
190 200 210 220 230 240
AVSYKEEPWA GGGNAGPCVE VLVHGLELAT LVFMDLKADK KGDVLIKGET YSKMDNYIVD
250 260 270 280 290 300
TGYGLERFVW ASKGSPTIYD ALFPGIVNEL MGLAGLEHEL DNSEYANILA QNARLAGFMD
310 320 330 340 350 360
VSEQSNLLEL RKKVASSIGM TVDKLSAIME PVEKVYAITD HTRCLTFMLG DGIIPSNVKA
370 380 390 400 410 420
GYLARLVIRR TLRMMDDLDI RIPLSEIMDM HIKNMPEYPE FRENFPVIQD ILVSEEEKFR
430 440 450 460 470 480
NTMEKGRRII QKSASHFKKT GEKIPLSQLT ELYDSHGIPP EMAKEVASEI GVGVEFPDNF
490 500 510 520 530 540
YSIIGELHNK AEEKEEEVVP FADRLKHLPK TKRSFYDEPT RLEFEAVVLD IFDNNIVLDN
550 560 570 580 590 600
TFFYAEGGGQ PADMGTIATA YAVYKVVDVQ VYDGVIVHTI ENPDGNLDIR KGDIVNGKVD
610 620 630 640 650 660
EKRRMTLARH HTATHIVNDA ARKVLGTHIW QAGAQKFEDH SRLDLSHYKH ISPDELKQIE
670 680 690 700 710 720
LLANRMVMEN KRVVTEWMSR TEAEQEYGFG LYQGGVPPGE KIRVVKVGDD VEACAGTHCV
730 740 750 760 770 780
STGVVGPIKI LRTERIQDGV ERVEFAAGVA AVRAMQKIDS LLSDSAKTLS VPPEQLPASV
790 800 810 820 830 840
ERFFGEWKDL KKENEKLKEE IARARVYRLL GGASEVAGLK VIAEFIPEAD SLELQKTATE
850 860 870 880 890 900
LLKHEDVVTL LASDAEGVKL VASAGQKALS CGINAGSLVR EMSKLVSGGG GGKPALAMGG
910 920
GTDPSKIQDA LARGLELVKE ACK