Q46AZ4

PR
Gene name
cca
Protein name
CCA-adding enzyme
Names
CCA tRNA nucleotidyltransferase, tRNA CCA-pyrophosphorylase, tRNA adenylyl-/cytidylyl- transferase, tRNA nucleotidyltransferase, tRNA-NT
Species
Methanosarcina barkeri (strain Fusaro / DSM 804)
KEGG Pathway
mba:Mbar_A2014
EC number
2.7.7.72: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-67 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q46AZ4

Entry ID Method Resolution Chain Position Source
AF-Q46AZ4-F1 Predicted AlphaFoldDB

No variants for Q46AZ4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q46AZ4

No associated diseases with Q46AZ4

3 regional properties for Q46AZ4

Type Name Position InterPro Accession
domain Cyclin, N-terminal 75 - 158 IPR006671
domain Cyclin-like domain 62 - 152 IPR013763
domain Cyclin, C-terminal domain 2 162 - 259 IPR031658

Functions

Description
EC Number 2.7.7.72 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

7 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity Catalysis of the reaction: a tRNA with a 3' CC end + ATP = a tRNA with a 3' CCA end + diphosphate.
CTP:3'-cytidine-tRNA cytidylyltransferase activity Catalysis of the reaction: a tRNA with a 3' cytidine + CTP = a tRNA with a 3' CC end + diphosphate.
CTP:tRNA cytidylyltransferase activity Catalysis of the reaction: a tRNA precursor + CTP = a tRNA with a 3' cytidine end + diphosphate.
magnesium ion binding Binding to a magnesium (Mg) ion.
tRNA binding Binding to a transfer RNA.
tRNA cytidylyltransferase activity Catalysis of the reaction: CTP + tRNA(n) = diphosphate + tRNA(n+1).

2 GO annotations of biological process

Name Definition
RNA repair Any process that results in the repair of damaged RNA.
tRNA 3'-terminal CCA addition Post-transcriptional addition of the terminal 3' CCA sequence to a tRNA which does not encode this sequence within the primary transcript. CCA addition proceeds by the sequential addition of CTP, CTP, and then ATP to the 3' end of the tRNA, yielding a diphosphate with each nucleotide addition.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
METYTGIPEE LKFAVLERIQ PTEPEREKLF AIQEELASQV KIAAEKLGIP GVLVKMVGSA
70 80 90 100 110 120
ARGTWLSGTH DIDVFISFPE ETSRKDLETL GMAIAREVAR YAEHAEDRHA EHPYLNITYK
130 140 150 160 170 180
GFDVDLVPCF RVASASQIKS AVDRTPFHND FVKPRIKGHE DEVLLLKQFM RGGGVYGSEL
190 200 210 220 230 240
KTQGFSGYLT ELLVIRYGSF KNTIYAACSW KPGEKIDIMQ HGEIEHEEPL VVIDPTDPRR
250 260 270 280 290 300
NVAAALSLDK FCTFIDHCRE FLKNPELSFF FPAPILPLED SEILEKLESR KSTQLAVVFK
310 320 330 340 350 360
TPDVVEDVLF PQLYKMEQAV AALLKEYDFT VIKTGVWSGN TETAVMMELI SGTLPNVKKH
370 380 390 400 410 420
IGPPVWVKVH AEKFKEKYQA ADGVFGGYIE NGKYIFEILR KYPTARGLLE DRLMSCSLGK
430 440 450
QVHQSVNEGF EIIENAGICR LKEYDFRIYL RKWI