Q46AN5

PR
Gene name
serS2 (Mbar_A2126)
Protein name
Type-2 serine--tRNA ligase
Names
Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase
Species
Methanosarcina barkeri (strain Fusaro / DSM 804)
KEGG Pathway
mba:Mbar_A2126
EC number
6.1.1.11: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-76 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

5 structures for Q46AN5

Entry ID Method Resolution Chain Position Source
2CIM X-ray 251 A A/B 1-502 PDB
2CJ9 X-ray 230 A A/B 1-502 PDB
2CJA X-ray 220 A A/B 1-502 PDB
2CJB X-ray 270 A A/B 1-502 PDB
AF-Q46AN5-F1 Predicted AlphaFoldDB

No variants for Q46AN5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q46AN5

No associated diseases with Q46AN5

2 regional properties for Q46AN5

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II 212 - 496 IPR006195
domain Serine-tRNA ligase type 2, tRNA-binding domain 3 - 158 IPR041293

Functions

Description
EC Number 6.1.1.11 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
serine-tRNA ligase activity Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser).
zinc ion binding Binding to a zinc ion (Zn).

3 GO annotations of biological process

Name Definition
selenocysteine biosynthetic process The chemical reactions and pathways resulting in the formation of selenocysteine, an essential component of glutathione peroxidase and some other proteins.
selenocysteinyl-tRNA(Sec) biosynthetic process The chemical reactions and pathways resulting in the formation of selenocysteinyl-tRNA(Sec). This process occurs through the following steps: a unique serine-tRNA with a UGA recognizing anticodon is first aminoacylated with serine; this is then phosphorylated by phosphoseryl-tRNA
seryl-tRNA aminoacylation The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. The seryl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a serine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKLQFNLKAY FKTSADPTPA KDAIAALFEE ANSTLLTRGA PEGQGAKVTE WKLGEDRIEL
70 80 90 100 110 120
TLQSGRYVRV HDAIFRLRKQ LAEALGKKYK IGIRGIEVES FIIKVPADHE LRMLKVPYIK
130 140 150 160 170 180
SMENIEGGIQ LELEVGEAEM KNRVPDRILT LLEEKIEAAQ YGAKAEHWNL LWQREPMEHP
190 200 210 220 230 240
FKEDPTQAMM KEGWLKRGSS RGQWIHGPQS ARIFRTFEKI VLEELLEPLG YREMIFPKLV
250 260 270 280 290 300
TWEVWMKSGH AKGVYPEIYY VCPPQTRDPD YWEEVADYYK VTHEVPTKLI KEKIAEPIGG
310 320 330 340 350 360
MCYAQCPPFW MYVAGETLPN EEIPVKVFDR SGTSHRYESG GIHGIERVDE FHRIEIVWIG
370 380 390 400 410 420
TKEEVLKCAE ELHDRYMHIF NDILDIEWRK ARVTPWFMAQ EGLLGLAEEN TVGTTDYEAC
430 440 450 460 470 480
LPYRGPDGEW LEFQNVSING DKYPKGFNVK LQSGDELWSG CSGVGLERWA AVFLAQKGLD
490 500
PANWPEEFRN RVGEMPKGIR FL