Q465R3

PR
Gene name
hel308
Protein name
ATP-dependent DNA helicase Hel308
Names
Species
Methanosarcina barkeri (strain Fusaro / DSM 804)
KEGG Pathway
mba:Mbar_A3508
EC number
5.6.2.4: Enzymes altering nucleic acid conformation
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

235-316 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q465R3

Entry ID Method Resolution Chain Position Source
AF-Q465R3-F1 Predicted AlphaFoldDB

No variants for Q465R3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q465R3

No associated diseases with Q465R3

2 regional properties for Q465R3

Type Name Position InterPro Accession
domain 4Fe-4S ferredoxin-type, iron-sulphur binding domain 25 - 93 IPR017896
conserved_site 4Fe-4S ferredoxin, iron-sulphur binding, conserved site 79 - 90 IPR017900

Functions

Description
EC Number 5.6.2.4 Enzymes altering nucleic acid conformation
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA helicase activity Unwinding of a DNA helix, driven by ATP hydrolysis.

1 GO annotations of biological process

Name Definition
DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKIESLDLPD EVKQFYLNSG IMELYPPQAE AVEKGLLEGR NLLAAIPTAS GKTLLAELAM
70 80 90 100 110 120
LKSILAGGKA LYIVPLRALA SEKFRRFREF SELGIRVGIS TGDYDLRDEG LGVNDIIVAT
130 140 150 160 170 180
SEKTDSLLRN ETVWMQEISV VVADEVHLID SPDRGPTLEV TLAKLRKMNP SCQILALSAT
190 200 210 220 230 240
VGNADELAVW LEAELVVSEW RPTELLEGVF FNGTFYCKDR EKTVEQSTKD EAVNLALDTL
250 260 270 280 290 300
KKDGQCLVFE SSRKNCMAFA KKAASTVKKT LSAEDRNALA GIADEILENS ETDTSTNLAV
310 320 330 340 350 360
CIRSGTAFHH AGLTTPLREL VEDGFRAGRI KLISSTPTLA AGLNLPARRV IIRNYRRYSS
370 380 390 400 410 420
EDGMQPIPVL EYKQMAGRAG RPRLDPYGEA VLVAKSYKEF VFLFENYIEA NAEDIWSKLG
430 440 450 460 470 480
TENALRTHVL STISNGFART YDELMDFLEA TFFAFQYSNF GLSTVVNECL NFLRQEGMLE
490 500 510 520 530 540
KDDALIPTSF GKLVSRLYID PLSAARIAKG LKGAKSLSEL TLLHLVCSTP DMRLLYMRSH
550 560 570 580 590 600
DYQDINDYVM AHASEFVKVP SPFDTTEYEW FLGEVKTSLL LLDWIHEKSE NEICLKFGTG
610 620 630 640 650 660
EGDIHSIADI AEWIMHVTSQ LAGLLDLKGA REAAELEKRI HYGAAPELID LLNIRGIGRV
670 680 690 700 710 720
RARKLYEAGF KSSAELAEVD PEKVAALLGP KIADRIFKQI RGRGTSSGII ASEPPEKSPY
SGQKTISDY