Q46455

PR
Gene name
selB
Protein name
Selenocysteine-specific elongation factor
Names
SelB translation factor
Species
Moorella thermoacetica (Clostridium thermoaceticum)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

126-264 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

6 structures for Q46455

Entry ID Method Resolution Chain Position Source
1LVA X-ray 212 A A 377-634 PDB
1WSU X-ray 230 A A/B/C/D 512-634 PDB
2PLY X-ray 260 A A/B 377-634 PDB
2UWM X-ray 231 A A/B 377-634 PDB
2V9V X-ray 110 A A 377-511 PDB
AF-Q46455-F1 Predicted AlphaFoldDB

No variants for Q46455

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q46455

No associated diseases with Q46455

6 regional properties for Q46455

Type Name Position InterPro Accession
domain Translational (tr)-type GTP-binding domain 1 - 173 IPR000795
domain Translation elongation factor EFTu-like, domain 2 194 - 260 IPR004161
domain Small GTP-binding protein domain 2 - 162 IPR005225
domain Translation elongation factor SelB, winged helix, type 1 377 - 437 IPR015189
domain Translation elongation factor SelB, winged helix, type 2 449 - 504 IPR015190
domain Translation elongation factor SelB, winged helix, type 3 587 - 630 IPR015191

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
RNA binding Binding to an RNA molecule or a portion thereof.
translation elongation factor activity Functions in chain elongation during polypeptide synthesis at the ribosome.

1 GO annotations of biological process

Name Definition
selenocysteine incorporation The incorporation of selenocysteine into a peptide; uses a special tRNA that recognizes the UGA codon as selenocysteine, rather than as a termination codon. Selenocysteine is synthesized from serine before its incorporation; it is not a posttranslational modification of peptidyl-cysteine.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDYIVVGTAG HVDHGKTVLV KALTGVDTDR LKEEKERGIS IELGFAPLTL PSGRQLGLVD
70 80 90 100 110 120
VPGHERFIRQ MLAGVGGMDL VMLVVAADEG VMPQTREHLA IIDLLQIKKG IIVITKIDLV
130 140 150 160 170 180
EADWLELVRE EVRQAVKGTV LEDAPLVEVS ALTGEGIAEL REQLDALAAV TPPRPAAGRV
190 200 210 220 230 240
RLPIDRVFSV TGFGTVVTGT LWSGTIKVGD ELEVQPEGLK TRARNLQVHG RTVKEARAGQ
250 260 270 280 290 300
RVAVNLAGIE TEAVHRGSSL LTPGFLTPTY RLDASFKLLN GARPLANRDR VHFYLGTSEA
310 320 330 340 350 360
LGRVVLLDRD ELNGGEEALI QLLMEKPVVA SREDRFILRS YSPMETIGGG IIIDPVPPKH
370 380 390 400 410 420
RRFQPEVLVS LQRRLEGSPE KILAQIIQEH REGLDWQEAA TRASLSLEET RKLLQSMAAA
430 440 450 460 470 480
GQVTLLRVEN DLYAISTERY QAWWQAVTRA LEEFHSRYPL RPGLAREELR SRYFSRLPAR
490 500 510 520 530 540
VYQALLEEWS REGRLQLAAN TVALAGFTPS FSETQKKLLK DLEDKYRVSR WQPPSFKEVA
550 560 570 580 590 600
GSFNLDPSEL EELLHYLVRE GVLVKINDEF YWHRQALGEA REVIKNLAST GPFGLAEARD
610 620 630
ALGSSRKYVL PLLEYLDQVK FTRRVGDKRV VVGN