Q45614

PR
Gene name
walK
Protein name
Sensor histidine kinase WalK
Names
Species
Bacillus subtilis (strain 168)
KEGG Pathway
bsu:BSU40400
EC number
2.7.13.3: Protein-histidine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

77-161 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for Q45614

Entry ID Method Resolution Chain Position Source
3SL2 X-ray 161 A A 451-611 PDB
AF-Q45614-F1 Predicted AlphaFoldDB

No variants for Q45614

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q45614

No associated diseases with Q45614

11 regional properties for Q45614

Type Name Position InterPro Accession
domain PAS domain 263 - 369 IPR000014
domain PAS-associated, C-terminal 325 - 379 IPR000700
repeat PAC motif 328 - 370 IPR001610
domain Histidine kinase/HSP90-like ATPase 488 - 602 IPR003594
domain HAMP domain 201 - 256 IPR003660
domain Signal transduction histidine kinase, dimerisation/phosphoacceptor domain 374 - 443 IPR003661
domain Signal transduction histidine kinase-related protein, C-terminal 527 - 541 IPR004358-1
domain Signal transduction histidine kinase-related protein, C-terminal 545 - 555 IPR004358-2
domain Signal transduction histidine kinase-related protein, C-terminal 562 - 580 IPR004358-3
domain Signal transduction histidine kinase-related protein, C-terminal 586 - 599 IPR004358-4
domain Histidine kinase domain 383 - 602 IPR005467

Functions

Description
EC Number 2.7.13.3 Protein-histidine kinases
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
phosphorelay response regulator activity Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response.
phosphorelay sensor kinase activity Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response.
protein kinase activator activity Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein.

1 GO annotations of biological process

Name Definition
osmosensory signaling via phosphorelay pathway The series of molecular signals generated in response to osmotic change, as mediated through a phosphorelay system.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNKVGFFRSI QFKITLIYVL LIIIAMQIIG VYFVNQVEKS LISSYEQSLN QRIDNLSYYI
70 80 90 100 110 120
EQEYKSDNDS TVIKDDVSRI LNDFTKSDEV REISFVDKSY EVVGSSKPYG EEVAGKQTTD
130 140 150 160 170 180
LIFKRIFSTK QSYLRKYYDP KSKIRVLISA KPVMTENQEV VGAIYVVASM EDVFNQMKTI
190 200 210 220 230 240
NTILASGTGL ALVLTALLGI FLARTITHPL SDMRKQAMEL AKGNFSRKVK KYGHDEIGQL
250 260 270 280 290 300
ATTFNHLTRE LEDAQAMTEG ERRKLASVIA YMTDGVIATN RNGAIILLNS PALELLNVSR
310 320 330 340 350 360
ETALEMPITS LLGLQENYTF EDLVEQQDSM LLEIERDDEL TVLRVNFSVI QREHGKIDGL
370 380 390 400 410 420
IAVIYDVTEQ EKMDQERREF VANVSHELRT PLTTMRSYLE ALAEGAWENK DIAPRFLMVT
430 440 450 460 470 480
QNETERMIRL VNDLLQLSKF DSKDYQFNRE WIQIVRFMSL IIDRFEMTKE QHVEFIRNLP
490 500 510 520 530 540
DRDLYVEIDQ DKITQVLDNI ISNALKYSPE GGHVTFSIDV NEEEELLYIS VKDEGIGIPK
550 560 570 580 590 600
KDVEKVFDRF YRVDKARTRK LGGTGLGLAI AKEMVQAHGG DIWADSIEGK GTTITFTLPY
610
KEEQEDDWDE A