Q45223

PR
Gene name
hbdA (blr1379)
Protein name
3-hydroxybutyryl-CoA dehydrogenase
Names
Beta-hydroxybutyryl-CoA dehydrogenase, BHBD
Species
Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110)
KEGG Pathway
bja:blr1379
EC number
1.1.1.157: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

18-95 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q45223

Entry ID Method Resolution Chain Position Source
AF-Q45223-F1 Predicted AlphaFoldDB

No variants for Q45223

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q45223

No associated diseases with Q45223

3 regional properties for Q45223

Type Name Position InterPro Accession
domain 3-hydroxyacyl-CoA dehydrogenase, C-terminal 189 - 284 IPR006108
domain 3-hydroxyacyl-CoA dehydrogenase, NAD binding 7 - 185 IPR006176
conserved_site 3-hydroxyacyl-CoA dehydrogenase, conserved site 185 - 210 IPR006180

Functions

Description
EC Number 1.1.1.157 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
3-hydroxybutyryl-CoA dehydrogenase activity Catalysis of the reaction: (S)-3-hydroxybutanoyl-CoA + NADP+ = 3-acetoacetyl-CoA + NADPH + H+.
NAD+ binding Binding to the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions.

3 GO annotations of biological process

Name Definition
butyrate metabolic process The chemical reactions and pathways involving any butyrate, the anions of butyric acid (butanoic acid), a saturated, unbranched aliphatic acid.
cellular catabolic process The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.
organic substance catabolic process The chemical reactions and pathways resulting in the breakdown of an organic substance, any molecular entity containing carbon.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAAVIKKVGV IGAGQMGNGI AHVAALAGFD VVLNDVSADR LKSGMATING NLARQVSKKV
70 80 90 100 110 120
VTEEAKTKAL SRIVAAEKLD DLADCDLVIE TAVEKEEVKR KIFHELCAVL KPEAIVASDT
130 140 150 160 170 180
SSISITRLAA ATDRPERFIG IHFMNPVPLM ELVELIRGIA TDDATFEASK EFVAKLGKQV
190 200 210 220 230 240
AVSEDFPAFI VNRILLPMIN EAIYTLYEGV GNVEAIDAAM KLGAHHPMGP LELADFIGLD
250 260 270 280 290
TCLSIMQVLH EGLADSKYRP CPLLVKYVEA GWLGRKTQRG FYDYRGAKPV PTR