Q44737
Gene name |
cheA (BB_0669) |
Protein name |
Chemotaxis protein CheA |
Names |
|
Species |
Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31) (Borrelia burgdorferi) |
KEGG Pathway |
bbu:BB_0669 |
EC number |
2.7.13.3: Protein-histidine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q44737
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q44737-F1 | Predicted | AlphaFoldDB |
No variants for Q44737
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q44737 | |||||
No associated diseases with Q44737
10 regional properties for Q44737
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | CheW-like domain | 717 - 861 | IPR002545 |
| domain | Histidine kinase/HSP90-like ATPase | 584 - 725 | IPR003594 |
| domain | Histidine kinase CheA-like, homodimeric domain | 411 - 539 | IPR004105 |
| domain | Signal transduction histidine kinase-related protein, C-terminal | 629 - 643 | IPR004358-1 |
| domain | Signal transduction histidine kinase-related protein, C-terminal | 669 - 679 | IPR004358-2 |
| domain | Signal transduction histidine kinase-related protein, C-terminal | 685 - 703 | IPR004358-3 |
| domain | Signal transduction histidine kinase-related protein, C-terminal | 709 - 722 | IPR004358-4 |
| domain | Histidine kinase domain | 480 - 725 | IPR005467 |
| domain | Signal transduction histidine kinase, phosphotransfer (Hpt) domain | 4 - 108 | IPR008207 |
| domain | Chemotaxis protein CheA, P2 response regulator-binding | 299 - 376 | IPR010808 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.13.3 | Protein-histidine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| phosphorelay sensor kinase activity | Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| chemotaxis | The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEILDLENEE | LLGVFFEEAQ | NLVDILEENI | MSLEDDPNNS | DTIDEIFRAA | HTLKGSSASL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DMMELSDFTH | IVEDVFDAIR | DGKVNINNDL | VDLLLSSLDV | IKEMLALRID | GKVYLNDISD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LKSKLKQFLV | IDDQTFIKRF | DGNSIKNNFC | LSESDLEEIR | EGLGIGQKVL | RISVVFNSNS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NSEVENSGLK | IFNILKNLGS | VLHTIPKYEQ | IIEDKFLKRV | DYYLIYSDIE | GVKKSLDSLN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LIESYLVDEF | NVKEELKKLA | DEEIKDVDLD | SNFVLNDNFD | FTEDEISDLL | LEVENQKLFK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VRLDFVKDNP | MATISGLQML | QALKSLGKIF | KSIPDSSELL | ADKFFDFVIY | YLISNTSEES |
| 370 | 380 | 390 | 400 | 410 | 420 |
| IAKKINLPDV | VSHFEIKNVN | LESLKSVRLK | EDDEAPFKEN | KNIKKNSPIS | VNLIRIDSKK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| IDYILNLVSE | AVISKSSYNQ | INSEMITLFY | NFNYFYDYQE | SFQRNFLIDL | KIVFKDAGLT |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LEDEIESHIN | SLMSFKMEKA | LKDISELRNS | FFRLLQNFKM | TSGRLSRIIT | DLHESVLKTR |
| 550 | 560 | 570 | 580 | 590 | 600 |
| MLPISNIFSR | FTRVVRDLSK | KLNKIVNLKM | EGEETELDKS | VIDDLVDPLM | HCVRNSMDHG |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LETVEERVKR | GKSKAGTIIL | RAKNEGNVIS | IEIEDDGIGI | DPKVIRRKLI | EKGTIKEDAI |
| 670 | 680 | 690 | 700 | 710 | 720 |
| YSDFELINLI | FAPGFSTAVQ | VTDLSGRGVG | LDVVKKSIEK | LNGTILVESE | IGLGTIFKIK |
| 730 | 740 | 750 | 760 | 770 | 780 |
| LPLTLVIIQG | LLVKSGSETY | VIPLNNVLET | HRITEHDIKL | LENYHEVYNL | RDEVISVLRL |
| 790 | 800 | 810 | 820 | 830 | 840 |
| DKLFNITRDD | SLIEKFLIVV | NTSNMKIAIV | VDSILGEEDF | VVKPIKDKFS | SSAGIVGATT |
| 850 | 860 | ||||
| LGNGKVVLII | DVFKLFDLQK | DTKE |