Q44270

PR
Gene name
gyrB
Protein name
DNA gyrase subunit B
Names
Species
Acinetobacter pittii (Acinetobacter genomosp 3)
KEGG Pathway
EC number
5.6.2.2: Enzymes altering nucleic acid conformation
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

247-326 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q44270

Entry ID Method Resolution Chain Position Source
AF-Q44270-F1 Predicted AlphaFoldDB

No variants for Q44270

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q44270

No associated diseases with Q44270

3 regional properties for Q44270

Type Name Position InterPro Accession
domain TOPRIM domain 312 - 388 IPR006171
domain DNA topoisomerase, type IIA, subunit B, domain 2 115 - 284 IPR013506
conserved_site DNA topoisomerase, type IIA, conserved site 316 - 324 IPR018522

Functions

Description
EC Number 5.6.2.2 Enzymes altering nucleic acid conformation
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined, driven by ATP hydrolysis. The enzyme changes the linking number in multiples of 2.

1 GO annotations of biological process

Name Definition
DNA topological change The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
DNSYKVSGGL HGVGVSVVNA LSSKLHLIIN RAGQVHEQEY HHGDPQYPLR VIGETDSSGT
70 80 90 100 110 120
TVRFWPSELT FSQTIFNVEI LARRLRELSF LNAGVRIVLR DERINLEHVY DYEGGLSEFV
130 140 150 160 170 180
KYINEGKTHL NEIFHFTADT ENGIGVEVAL QWNESYQENV RCFTNNIPQK DGGTHLAGFR
190 200 210 220 230 240
AALTRGLNQY LENENILKKE KVNVTGDDAR EGLTAIISVK VPDPKFSSQT KEKLVSSEVK
250 260 270 280 290 300
PAVEQAMNKE FSAYLLENPQ AAKSIAGKII DAARARDAAR KAREMTRRKS ALDIAGLPGK
310 320 330 340 350 360
LADCQEKDPA LSELYLVEGD SAGGSAKQGR NRKMQAILPL KGKILNVERA RFDKMISSQE
370 380
VGTLITALGC GIGREEYNPD KLRYHKII