Q42598

PR
Gene name
thrc (SPAC9E9.06c)
Protein name
Threonine synthase
Names
TS
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC9E9.06c
EC number
4.2.3.1: Acting on phosphates
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-42 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q42598

Entry ID Method Resolution Chain Position Source
AF-Q42598-F1 Predicted AlphaFoldDB

3 variants for Q42598

Variant ID(s) Position Change Description Diseaes Association Provenance
I_4446638_C_T 258 G>E No Jeffares_SNPs
I_4446236_C_T 392 R>H No Jeffares_SNPs
I_4446120_G_A 431 L>F No Jeffares_SNPs

No associated diseases with Q42598

5 regional properties for Q42598

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 291 - 500 IPR002314
domain Anticodon-binding 521 - 608 IPR004154
domain Aminoacyl-tRNA synthetase, class II 215 - 514 IPR006195
domain Threonyl-tRNA synthetase, editing domain, archaea 1 - 137 IPR015011
domain Threonine-tRNA ligase, class IIa, anticodon-binding domain 519 - 611 IPR047246

Functions

Description
EC Number 4.2.3.1 Acting on phosphates
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
pyridoxal phosphate binding Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.
threonine synthase activity Catalysis of the reaction: O-phospho-L-homoserine + H2O = L-threonine + phosphate.

1 GO annotations of biological process

Name Definition
threonine biosynthetic process The chemical reactions and pathways resulting in the formation of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSSQVSYLST RGGSSNFSFE EAVLKGLAND GGLFIPSEIP QLPSGWIEAW KDKSFPEIAF
70 80 90 100 110 120
EVMSLYIPRS EISADELKKL VDRSYSTFRH PETTPLKSLK NGLNVLELFH GPTFAFKDVA
130 140 150 160 170 180
LQFLGNLFEF FLTRKNGNKP EDERDHLTVV GATSGDTGSA AIYGLRGKKD VSVFILFPNG
190 200 210 220 230 240
RVSPIQEAQM TTVTDPNVHC ITVNGVFDDC QDLVKQIFGD VEFNKKHHIG AVNSINWARI
250 260 270 280 290 300
LSQITYYLYS YLSVYKQGKA DDVRFIVPTG NFGDILAGYY AKRMGLPTKQ LVIATNENDI
310 320 330 340 350 360
LNRFFKTGRY EKADSTQVSP SGPISAKETY SPAMDILVSS NFERYLWYLA LATEAPNHTP
370 380 390 400 410 420
AEASEILSRW MNEFKRDGTV TVRPEVLEAA RRDFVSERVS NDETIDAIKK IYESDHYIID
430 440 450 460 470 480
PHTAVGVETG LRCLEKTKDQ DITYICLSTA HPAKFDKAVN LALSSYSDYN FNTQVLPIEF
490 500 510
DGLLDEERTC IFSGKPNIDI LKQIIEVTLS REKA