Q41594

PR
Gene name
TDC1
Protein name
Taxadiene synthase
Names
Taxa-4(5),11(12)-diene synthase
Species
Taxus brevifolia (Pacific yew)
KEGG Pathway
ag:AAC49310
EC number
4.2.3.17: Acting on phosphates
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-104 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for Q41594

Entry ID Method Resolution Chain Position Source
3P5P X-ray 182 A A 108-862 PDB
3P5R X-ray 225 A A/B 108-862 PDB
AF-Q41594-F1 Predicted AlphaFoldDB

No variants for Q41594

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q41594

No associated diseases with Q41594

3 regional properties for Q41594

Type Name Position InterPro Accession
domain Terpene synthase, N-terminal domain 296 - 496 IPR001906
domain Terpene synthase, metal-binding domain 541 - 803 IPR005630
domain Terpene cyclase-like 1, C-terminal domain 536 - 861 IPR034741

Functions

Description
EC Number 4.2.3.17 Acting on phosphates
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
magnesium ion binding Binding to a magnesium (Mg) ion.
taxadiene synthase activity Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = diphosphate + taxa-4,11-diene.
terpene synthase activity Catalysis of the formation of cyclic terpenes through the cyclization of linear terpenes (e.g. isopentenyl-PP, geranyl-PP, farnesyl-PP and geranylgeranyl-PP) containing varying numbers of isoprene units.

1 GO annotations of biological process

Name Definition
paclitaxel biosynthetic process The chemical reactions and pathways resulting in the formation of paclitaxel, a tetracyclic diterpenoid isolated originally from the bark of the Pacific yew tree, Taxus brevifolia.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAQLSFNAAL KMNALGNKAI HDPTNCRAKS ERQMMWVCSR SGRTRVKMSR GSGGPGPVVM
70 80 90 100 110 120
MSSSTGTSKV VSETSSTIVD DIPRLSANYH GDLWHHNVIQ TLETPFRESS TYQERADELV
130 140 150 160 170 180
VKIKDMFNAL GDGDISPSAY DTAWVARLAT ISSDGSEKPR FPQALNWVFN NQLQDGSWGI
190 200 210 220 230 240
ESHFSLCDRL LNTTNSVIAL SVWKTGHSQV QQGAEFIAEN LRLLNEEDEL SPDFQIIFPA
250 260 270 280 290 300
LLQKAKALGI NLPYDLPFIK YLSTTREARL TDVSAAADNI PANMLNALEG LEEVIDWNKI
310 320 330 340 350 360
MRFQSKDGSF LSSPASTACV LMNTGDEKCF TFLNNLLDKF GGCVPCMYSI DLLERLSLVD
370 380 390 400 410 420
NIEHLGIGRH FKQEIKGALD YVYRHWSERG IGWGRDSLVP DLNTTALGLR TLRMHGYNVS
430 440 450 460 470 480
SDVLNNFKDE NGRFFSSAGQ THVELRSVVN LFRASDLAFP DERAMDDARK FAEPYLREAL
490 500 510 520 530 540
ATKISTNTKL FKEIEYVVEY PWHMSIPRLE ARSYIDSYDD NYVWQRKTLY RMPSLSNSKC
550 560 570 580 590 600
LELAKLDFNI VQSLHQEELK LLTRWWKESG MADINFTRHR VAEVYFSSAT FEPEYSATRI
610 620 630 640 650 660
AFTKIGCLQV LFDDMADIFA TLDELKSFTE GVKRWDTSLL HEIPECMQTC FKVWFKLMEE
670 680 690 700 710 720
VNNDVVKVQG RDMLAHIRKP WELYFNCYVQ EREWLEAGYI PTFEEYLKTY AISVGLGPCT
730 740 750 760 770 780
LQPILLMGEL VKDDVVEKVH YPSNMFELVS LSWRLTNDTK TYQAEKARGQ QASGIACYMK
790 800 810 820 830 840
DNPGATEEDA IKHICRVVDR ALKEASFEYF KPSNDIPMGC KSFIFNLRLC VQIFYKFIDG
850 860
YGIANEEIKD YIRKVYIDPI QV