Q41583

PR
Gene name
Protein name
Eukaryotic translation initiation factor isoform 4G-2
Names
eIF(iso)-4G-2, eIF(iso)4G-2, Eukaryotic initiation factor iso-4F subunit p82-16, eIF-(iso)4F p82-16 subunit
Species
Triticum aestivum (Wheat)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

119-201 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q41583

Entry ID Method Resolution Chain Position Source
AF-Q41583-F1 Predicted AlphaFoldDB

No variants for Q41583

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q41583

No associated diseases with Q41583

6 regional properties for Q41583

Type Name Position InterPro Accession
domain Protein kinase domain 191 - 453 IPR000719
domain AGC-kinase, C-terminal 454 - 533 IPR000961
domain Pleckstrin homology domain 558 - 654 IPR001849
active_site Serine/threonine-protein kinase, active site 313 - 325 IPR008271
domain RGS domain 54 - 175 IPR016137
binding_site Protein kinase, ATP binding site 197 - 220 IPR017441

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
eukaryotic translation initiation factor 4F complex The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome.

2 GO annotations of molecular function

Name Definition
mRNA binding Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
translation initiation factor activity Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P78344 EIF4G2 Eukaryotic translation initiation factor 4 gamma 2 Homo sapiens (Human) PR
O43432 EIF4G3 Eukaryotic translation initiation factor 4 gamma 3 Homo sapiens (Human) EV
Q04637 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 Homo sapiens (Human) EV
Q62448 Eif4g2 Eukaryotic translation initiation factor 4 gamma 2 Mus musculus (Mouse) PR
Q80XI3 Eif4g3 Eukaryotic translation initiation factor 4 gamma 3 Mus musculus (Mouse) SS
Q6NZJ6 Eif4g1 Eukaryotic translation initiation factor 4 gamma 1 Mus musculus (Mouse) SS
10 20 30 40 50 60
MTTDQPVISL RPGGGGGGPR GGRLFAPAFA VAASGSGDFL RPHGGGAFRA LQDWCLHLSH
70 80 90 100 110 120
ERVRYSRDQL LDLRKITDVT EQILRLQQEI EAELHGDDQS WVRNDSNVQL QTQTQTQVQA
130 140 150 160 170 180
QNRFTETDNR DWRARTEKPP APAVPEEKSW DNIREVKEQY NASGRQQEQF NRQDQSSSQK
190 200 210 220 230 240
AQVGPPPALI KADVPWSARR GNLSEKDRVL KTVKGILNKL TPEKFDLLKG ELLDSGITTA
250 260 270 280 290 300
DILKDVISLI FEKAVFEPTF CPMYAQLCSE LNDNLPKFPS EEPGGKEITF KRVLLNNCQE
310 320 330 340 350 360
AFEGADSLRV EIASLTGPDQ EMEKRDKERI FKLRTLGNIR LIGELLKQKM VPEKIVHHIV
370 380 390 400 410 420
KELLGSDKKA CPDEEHVEAI CQFFNTIGKQ LDENPKSRRI NDTYFVHLRE LVANPQLTPR
430 440 450 460 470 480
SKFMVRDLID LRSNNWVPRR AEIKAKTISE IHTEAEKNLG LRPGATANMR NGRNAPGGPL
490 500 510 520 530 540
SPGGFSVNRP GTGGMMPGMP GSRKMPGMPG LDNDNWEVQR SRSMPRGDPL RNQGSLINKV
550 560 570 580 590 600
SSINKPSPIN PRLLPQGTGA LIGKSALLGT GGPPSRPSSI TASPTPLPAQ TTASPKPSSA
610 620 630 640 650 660
TPASVPIPDK AASSAKVIPA GLEKKTASLL EEYFGIRILD EAQQCIEELQ SPDYHPEIVK
670 680 690 700 710 720
EAINLALDKG ASFVDPLVKL LEHLYTKKTF KTEDLENGCL LYGSLLEDIG IDLPKAPTQF
730 740 750 760 770 780
GEVIARLILS CGLRFEAVEG ILKAMEDTFF RKAIFTSVTK TLEADPAGQA ILSSHAAVVD
ACNSLSI