Q40541

PR
Gene name
NPK1
Protein name
Mitogen-activated protein kinase kinase kinase NPK1
Names
Nicotiana protein kinase 1
Species
Nicotiana tabacum (Common tobacco)
KEGG Pathway
nta:107796336
EC number
2.7.11.25: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-96 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

225-234 (Activation loop from InterPro)

Target domain

80-342 (Protein kinase domain)

Relief mechanism

Assay

245-250 (Activation loop from InterPro)

Target domain

80-342 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q40541

Entry ID Method Resolution Chain Position Source
AF-Q40541-F1 Predicted AlphaFoldDB

No variants for Q40541

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q40541

No associated diseases with Q40541

3 regional properties for Q40541

Type Name Position InterPro Accession
domain Protein kinase domain 80 - 342 IPR000719
active_site Serine/threonine-protein kinase, active site 204 - 216 IPR008271
binding_site Protein kinase, ATP binding site 86 - 109 IPR017441

Functions

Description
EC Number 2.7.11.25 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • Cytoplasm, cytoskeleton, phragmoplast
  • In interphase and prophase, detected in the nucleus
  • From prometaphase to metaphase, found in the cytoplasm in patches
  • At anaphase, distributed around the spindle midzone and on the phragmoplast equator at telophase and then redistributed to the newly forming daughter nuclei
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoskeleton A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
phragmoplast Fibrous structure (light microscope view) that arises between the daughter nuclei at telophase and within which the initial partition (cell plate), dividing the mother cell in two (cytokinesis), is formed. Appears at first as a spindle connected to the two nuclei, but later spreads laterally in the form of a ring. Consists of microtubules.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
MAP kinase kinase kinase activity Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases.
protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.

4 GO annotations of biological process

Name Definition
cell plate assembly The process of assembly, maturation, and growth of the cell plate to the cell periphery in cells that divide by cell plate formation; often involves deposition of cell wall material in and around the phragmoplast.
defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.
protein phosphorylation The process of introducing a phosphate group on to a protein.
signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQDFIGSVRR SLVFKQSGDF DTGAAGVGSG FGGFVEKLGS SIRKSSIGIF SKAHVPALPS
70 80 90 100 110 120
ISKAELPAKA RKDDTPPIRW RKGEMIGCGA FGRVYMGMNV DSGELLAIKE VSIAMNGASR
130 140 150 160 170 180
ERAQAHVREL EEEVNLLKNL SHPNIVRYLG TAREAGSLNI LLEFVPGGSI SSLLGKFGSF
190 200 210 220 230 240
PESVIRMYTK QLLLGLEYLH KNGIMHRDIK GANILVDNKG CIKLADFGAS KKVVELATMT
250 260 270 280 290 300
GAKSMKGTPY WMAPEVILQT GHSFSADIWS VGCTIIEMAT GKPPWSQQYQ EVAALFHIGT
310 320 330 340 350 360
TKSHPPIPEH LSAESKDFLL KCLQKEPHLR HSASNLLQHP FVTAEHQEAR PFLRSSFMGN
370 380 390 400 410 420
PENMAAQRMD VRTSIIPDMR ASCNGLKDVC GVSAVRCSTV YPENSLGKES LWKLGNSDDD
430 440 450 460 470 480
MCQMDNDDFM FGASVKCSSD LHSPANYKSF NPMCEPDNDW PCKFDESPEL TKSQANLHYD
490 500 510 520 530 540
QATIKPTNNP IMSYKEDLAF TFPSGQSAAE DDDELTESKI RAFLDEKAMD LKKLQTPLYE
550 560 570 580 590 600
GFYNSLNVSS TPSPVGTGNK ENVPSNINLP PKSRSPKRML SRRLSTAIEG ACAPSPVTHS
610 620 630 640 650 660
KRISNIGGLN GEAIQEAQLP RHNEWKDLLG SQREAVNSSF SERQRRWKEE LDEELQRKRE
670 680
IMRQAVNLSP PKDPILNRCR SKSRFASPGR