Q40469

PR
Gene name
Protein name
Eukaryotic initiation factor 4A-6
Names
eIF-4A-6, ATP-dependent RNA helicase eIF4A-6
Species
Nicotiana tabacum (Common tobacco)
KEGG Pathway
EC number
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

118-187 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q40469

Entry ID Method Resolution Chain Position Source
AF-Q40469-F1 Predicted AlphaFoldDB

No variants for Q40469

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q40469

No associated diseases with Q40469

3 regional properties for Q40469

Type Name Position InterPro Accession
domain Protein kinase domain 40 - 325 IPR000719
active_site Serine/threonine-protein kinase, active site 153 - 165 IPR008271
binding_site Protein kinase, ATP binding site 46 - 69 IPR017441

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.
translation initiation factor activity Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.

1 GO annotations of biological process

Name Definition
cytoplasmic translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
HVVVGTPGRV FDMLRRQSLR PDNIKMFVLD EADEMLSRGF KDQIYDIFQL LPPKIQVGIF
70 80 90 100 110 120
SATMPPEALE ITRKFMNKPV RILVKRDELT LEGIKQFYVN VDKEEWKLET LCDLYETLAI
130 140 150 160 170 180
TQSVIFVNTR RKVDWLTDKM RGRDHTVSAT HGDMDQNTRD IIMREFRSGS SRVLITTDLL
190 200 210 220 230 240
ARGIDVQQVS LVINYDLPTQ PENYLHRIGR SGRFGRKGVS INFVTKDDER MLFDIQKFYN
250
VVIEELPANV ADL