AiPD: Autoinhibited Protein Database

Q3ZCV2

Gene name	LEXM
Protein name	Lymphocyte expansion molecule
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:163747
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

152-279 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

152-279 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q3ZCV2

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q3ZCV2-F1	Predicted				AlphaFoldDB

391 variants for Q3ZCV2

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA340452206 rs1320606874	2	R>T		No	ClinGen gnomAD
rs1302118356 CA340452218	3	E>Q		No	ClinGen TOPMed
CA22750070 rs1045595675	5	Q>R		No	ClinGen TOPMed
CA870010 rs755832953	6	D>G		No	ClinGen ExAC TOPMed gnomAD
CA340452351 rs755832953	6	D>V		No	ClinGen ExAC TOPMed gnomAD
rs778932006 CA870016	8	A>D		No	ClinGen ExAC gnomAD
CA870013 rs371601615	8	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA870014 rs371601615	8	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs778932006 CA870015	8	A>V		No	ClinGen ExAC gnomAD
rs1557782388 CA340452500	11	H>P		No	ClinGen Ensembl
CA340452579 rs1203776743	14	N>D		No	ClinGen TOPMed gnomAD
rs1203776743 CA340452573	14	N>H		No	ClinGen TOPMed gnomAD
rs1265316524 CA340452619	15	R>C		No	ClinGen gnomAD
rs1166848836 CA340452630	16	V>I		No	ClinGen gnomAD
rs961245444 CA340452658	17	G>A		No	ClinGen TOPMed gnomAD
rs961245444 CA22750123	17	G>D		No	ClinGen TOPMed gnomAD
CA340452651 rs771231580	17	G>R		No	ClinGen ExAC gnomAD
CA870020 rs771231580	17	G>S		No	ClinGen ExAC gnomAD
rs776559077 CA870021	18	S>P		No	ClinGen ExAC gnomAD
rs72895754 CA870023	19	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA340452687 rs1342980332	20	A>D		No	ClinGen TOPMed gnomAD
CA22750156 rs940967540	22	K>R		No	ClinGen TOPMed gnomAD
rs1203723565 CA340452758	23	W>C		No	ClinGen TOPMed
rs1359976823 CA340452752	23	W>L		No	ClinGen gnomAD
rs1557782486 CA340452762	24	F>L		No	ClinGen Ensembl
rs1557782486 CA340452760	24	F>V		No	ClinGen Ensembl
rs1444804260 CA340452812	26	G>A		No	ClinGen TOPMed gnomAD
rs775927530 CA870024 CA340452806	26	G>R		No	ClinGen ExAC TOPMed gnomAD
rs1321514227 CA340452817	27	A>T		No	ClinGen TOPMed
rs868010478 CA22750162	27	A>V		No	ClinGen gnomAD
rs1280114145 CA340452829	28	P>S		No	ClinGen TOPMed
rs774829864 CA870027	29	F>C		No	ClinGen ExAC gnomAD
rs760234083 CA870028 CA340452865	30	G>R		No	ClinGen ExAC gnomAD
rs866917675 CA22750186	31	V>A		No	ClinGen Ensembl
rs569094306 CA870030	31	V>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs569094306 CA870029	31	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1473495996 CA340452910	33	S>G		No	ClinGen TOPMed gnomAD
TCGA novel	37	D>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	40	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs757018614 CA340453327	43	P>H		No	ClinGen ExAC TOPMed gnomAD
rs757018614 CA870055	43	P>R		No	ClinGen ExAC TOPMed gnomAD
CA340453324 rs751456097	43	P>S		No	ClinGen ExAC gnomAD
CA870054 rs751456097	43	P>T		No	ClinGen ExAC gnomAD
CA870056 rs371279186	44	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA340453390 rs1281558223	48	F>L		No	ClinGen TOPMed
rs750613255 CA870057	50	T>A		No	ClinGen ExAC gnomAD
CA870059 rs780095968	53	E>Q		No	ClinGen ExAC gnomAD
rs749454922 CA870060	54	A>T		No	ClinGen ExAC gnomAD
CA340453471 rs1384145942	54	A>V		No	ClinGen TOPMed
COSM350082 CA870061 rs768626695	55	P>L	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA870062 rs113358192	57	S>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA870063 rs564288036	58	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs773749433 CA870065 COSM191923	59	R>C	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA870066 rs773749433	59	R>G		No	ClinGen ExAC TOPMed gnomAD
CA870067 rs202144840	59	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs1332625405 CA340453533	60	Y>*		No	ClinGen gnomAD
rs115158797 CA870068	60	Y>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA870069 rs762458770	63	Q>E		No	ClinGen ExAC TOPMed gnomAD
rs761794966 CA870089	66	H>Q		No	ClinGen ExAC gnomAD
rs1191101614 CA340453607	67	I>K		No	ClinGen gnomAD
CA340453605 rs1428066766	67	I>V		No	ClinGen gnomAD
rs767508565 CA870090	68	G>S		No	ClinGen ExAC TOPMed gnomAD
rs773135491 CA870091	68	G>V		No	ClinGen ExAC gnomAD
rs1021024984 CA22751254	69	P>L		No	ClinGen TOPMed gnomAD
rs760402084 CA870092	69	P>S		No	ClinGen ExAC TOPMed gnomAD
rs754055679 CA870094	74	S>P		No	ClinGen ExAC gnomAD
CA870095 rs146088179	75	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs752779858 CA870097	76	E>A		No	ClinGen ExAC gnomAD
CA870099 rs778359724	78	C>G		No	ClinGen ExAC TOPMed gnomAD
CA340453675 rs1485816911	78	C>S		No	ClinGen gnomAD
rs747533556 CA870100	80	S>G		No	ClinGen ExAC gnomAD
CA870101 rs757647863	81	K>T		No	ClinGen ExAC gnomAD
TCGA novel	83	K>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs781449937 CA870102	83	K>Q		No	ClinGen ExAC gnomAD
CA340453713 rs1453291497	83	K>T		No	ClinGen TOPMed
rs1281701791 CA340453716	84	L>M		No	ClinGen gnomAD
CA870103 rs748948493	86	K>N		No	ClinGen ExAC TOPMed gnomAD
rs372048254 CA22751271	87	E>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs372048254 CA870104	87	E>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA340453778 rs1451583403	90	T>I		No	ClinGen gnomAD
CA340453787 rs1421872601	91	G>A		No	ClinGen TOPMed
rs1406189201 CA340453781	91	G>S		No	ClinGen gnomAD
CA340453793 rs1570132470	92	W>G		No	ClinGen Ensembl
rs944230387 CA22751282	96	Q>K		No	ClinGen Ensembl
rs267598656 CA22751289	97	E>K		No	ClinGen Ensembl
rs1334359233 CA340453872 COSM1343548	99	T>A	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs368525051 CA870107	99	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA870110 rs766169578	100	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA870109 rs142483178	100	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA340453900 rs1009830017	102	T>P		No	ClinGen Ensembl
rs765447741 CA870113	102	T>S		No	ClinGen ExAC TOPMed gnomAD
rs1009830017 CA22751300	102	T>S		No	ClinGen Ensembl
CA340453909 rs1439078389	103	Q>E		No	ClinGen TOPMed
CA340453912 rs1570132574	103	Q>P		No	ClinGen Ensembl
rs1203111261 CA340453928	105	P>T		No	ClinGen TOPMed gnomAD
CA340453947 rs1213642918	106	H>P		No	ClinGen TOPMed
rs1213642918 CA340453946	106	H>R		No	ClinGen TOPMed
CA340453968 rs1241596902	108	Q>*		No	ClinGen TOPMed gnomAD
rs558450851 CA870115	110	Q>*		No	ClinGen 1000Genomes ExAC gnomAD
rs558450851 CA22751301	110	Q>K		No	ClinGen 1000Genomes ExAC gnomAD
CA870119 rs752073834	113	M>T		No	ClinGen ExAC gnomAD
CA340454065 rs577954332	115	E>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA870123 rs201438425	117	R>Q	Variant assessed as Somatic; 4.832e-05 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs202224828 CA870122	117	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA340454216 rs1224494366	124	G>C		No	ClinGen gnomAD
TCGA novel	124	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA870146 rs373507359	125	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA340454261 rs868510092	126	G>A		No	ClinGen TOPMed
CA870148 VAR_034645 rs9782980	126	G>C		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA22751541 rs868510092	126	G>D		No	ClinGen TOPMed
CA870149 rs9782980	126	G>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA22751549 rs1041230634	127	S>T		No	ClinGen Ensembl
CA870151 rs780935770	127	S>Y		No	ClinGen ExAC TOPMed gnomAD
rs1185420548 CA340454282	128	Y>C		No	ClinGen TOPMed gnomAD
CA340454307 rs1433389856	129	N>S		No	ClinGen TOPMed
rs1417011599 CA340454360	131	K>R		No	ClinGen gnomAD
CA340454372 rs1446052060	132	D>G		No	ClinGen gnomAD
rs913474423 CA22751560	134	L>V		No	ClinGen gnomAD
rs775466852 CA870154	136	Q>R		No	ClinGen ExAC gnomAD
CA870155 rs763253855	137	L>Q		No	ClinGen ExAC gnomAD
rs774718397 CA870157	138	R>Q		No	ClinGen ExAC gnomAD
rs147950628 CA870156	138	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA340454458 rs1362177938	139	E>D		No	ClinGen gnomAD
CA340454447 rs1248465890	139	E>K		No	ClinGen gnomAD
rs749894210 CA870160	140	K>RGQ*		No	ClinGen ExAC
rs1570133154 CA340454482	141	P>L		No	ClinGen Ensembl
rs767655117 CA870163	142	C>R		No	ClinGen ExAC TOPMed gnomAD
CA870164 rs147552277	144	T>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
COSM535551 rs1447491950 CA340454546	145	R>Q	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs766703561 CA870166	145	R>W		No	ClinGen ExAC TOPMed gnomAD
CA870168 rs758044158	146	G>R		No	ClinGen ExAC gnomAD
rs1384217002 CA340454621	149	S>G		No	ClinGen gnomAD
CA870170 rs148177060	150	S>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1388494037 CA340454701	152	E>G		No	ClinGen gnomAD
rs528921936 CA22751655	153	V>F		No	ClinGen 1000Genomes TOPMed
rs141936308 CA870172 COSM910957	154	R>C	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
COSM3400897 CA340454725 rs1401825123	154	R>H	Variant assessed as Somatic; 0.0 impact. central_nervous_system [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs745763474 CA870173	155	F>L		No	ClinGen ExAC gnomAD
CA870174 rs138973950	156	R>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs138973950 CA870175	156	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs749022045 CA870176	156	R>P		No	ClinGen ExAC gnomAD
rs749022045 CA340454755	156	R>Q		No	ClinGen ExAC gnomAD
CA22751704 rs1014787270	158	L>F		No	ClinGen gnomAD
CA22751706 rs961952304	160	G>V		No	ClinGen Ensembl
rs892783223 CA22754052	162	Y>C		No	ClinGen TOPMed gnomAD
CA870211 rs767131445	165	G>D		No	ClinGen ExAC TOPMed gnomAD
rs1050412158 CA22754063	166	P>S		No	ClinGen TOPMed gnomAD
rs890529834 CA22754067	168	N>D		No	ClinGen Ensembl
rs185058391 CA870213	169	Y>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs766015942 CA870214	170	G>A		No	ClinGen ExAC gnomAD
rs1277292543 CA340455826	170	G>R		No	ClinGen TOPMed
rs755010362 CA870216	171	E>A		No	ClinGen ExAC TOPMed gnomAD
rs753793925 CA870215	171	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA870217 rs778555274	173	G>D		No	ClinGen ExAC TOPMed gnomAD
CA340455922 rs1322760019	175	P>S		No	ClinGen gnomAD
rs72671882 CA340455958	176	Y>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
COSM535549 rs1465543918 CA340455950	176	Y>F	lung Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
rs758136910 CA870219	176	Y>H		No	ClinGen ExAC TOPMed gnomAD
rs1250133325 CA340456023	181	E>Q		No	ClinGen gnomAD
rs1011504398 CA22754109	183	A>P		No	ClinGen Ensembl
CA340456099 rs1347113880	183	A>V		No	ClinGen TOPMed gnomAD
rs747220751 CA870221 TCGA novel	184	W>*	Variant assessed as Somatic; impact. Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA ClinGen ExAC gnomAD
rs781291820 CA340456151	186	R>L		No	ClinGen ExAC TOPMed gnomAD
rs781291820 CA870224	186	R>P		No	ClinGen ExAC TOPMed gnomAD
rs781291820 CA870223	186	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs557753528 CA870222	186	R>W		No	ClinGen ExAC TOPMed gnomAD
CA22754114 rs867793576	188	H>Y		No	ClinGen Ensembl
CA22754127 rs970067420	190	E>G		No	ClinGen Ensembl
CA870226 rs139677684	190	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA870228 rs763318737	191	G>A		No	ClinGen ExAC TOPMed gnomAD
CA870229 rs763318737	191	G>D		No	ClinGen ExAC TOPMed gnomAD
CA340456207 rs1338321927	191	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA870227 rs763318737	191	G>V		No	ClinGen ExAC TOPMed gnomAD
CA22754133 rs140694038	192	L>F		No	ClinGen ESP TOPMed
CA870230 rs760440349	193	M>I		No	ClinGen ExAC gnomAD
rs960369699 CA22754143	196	M>I		No	ClinGen TOPMed gnomAD
rs368521655 CA870231	196	M>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA22754140 rs927648503	196	M>T		No	ClinGen Ensembl
CA870232 rs753453051	198	N>K		No	ClinGen ExAC gnomAD
CA870235 rs371945610	201	H>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA870234 rs765159171	201	H>Y		No	ClinGen ExAC TOPMed
rs150096503 CA870236	202	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs560071108 CA870238	203	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA870237 rs777462327 COSM1560562	203	R>W	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA340456512 rs1424984108	204	P>T		No	ClinGen TOPMed gnomAD
CA340456521 rs600499	205	H>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs600499 CA22754195 VAR_054410	205	H>Y		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA870240 rs781236008	206	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA870263 rs749777216	209	G>A		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	209	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA340456725 rs1241820340	210	L>M		No	ClinGen TOPMed gnomAD
rs1022924490 CA22754335	212	P>L		No	ClinGen Ensembl
CA22754348 rs1002422438	213	G>S		No	ClinGen TOPMed
rs779412486 CA870265	214	T>A		No	ClinGen ExAC TOPMed gnomAD
CA22754353 rs184975243	215	Y>D		No	ClinGen 1000Genomes
rs1557786120 CA340456854	215	Y>S		No	ClinGen Ensembl
TCGA novel	216	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA870269 rs776376193	217	F>S		No	ClinGen ExAC gnomAD
CA870271 rs745550266	218	K>R		No	ClinGen ExAC gnomAD
rs769319377 CA870272	219	S>I		No	ClinGen ExAC TOPMed gnomAD
rs1455242030 CA340456996	220	D>A		No	ClinGen gnomAD
rs148767357 CA870274	220	D>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA870275 rs764007137	221	L>F		No	ClinGen ExAC gnomAD
CA870277 rs761545032	224	Y>H		No	ClinGen ExAC gnomAD
rs1240756011 CA340457145	226	A>T		No	ClinGen TOPMed
rs1570138822 CA340457165	226	A>V		No	ClinGen Ensembl
rs373289406 CA870278	227	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs750612882 CA340457174	227	R>P		No	ClinGen ExAC gnomAD
rs750612882 CA870279	227	R>Q	Variant assessed as Somatic; 0.000231 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs753930400 CA870282	229	V>I		No	ClinGen ExAC TOPMed gnomAD
rs539683546 CA870284	230	G>S		No	ClinGen 1000Genomes ExAC gnomAD
rs556342674 CA870285	231	T>P		No	ClinGen 1000Genomes ExAC gnomAD
CA870287 rs778325351	232	R>C		No	ClinGen ExAC TOPMed gnomAD
CA870288 rs552406217	232	R>H		No	ClinGen ExAC TOPMed gnomAD
rs775062915 CA870290	233	G>S		No	ClinGen ExAC TOPMed gnomAD
CA340457328 rs1413337028	234	P>L		No	ClinGen gnomAD
CA523275205 rs1451238188	235	Y>*		No	ClinGen gnomAD
rs748681740 CA870293	235	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA340457404 rs1197703505	238	F>C		No	ClinGen TOPMed
CA870294 rs768175631	238	F>L		No	ClinGen ExAC gnomAD
CA340457403 rs1197703505	238	F>S		No	ClinGen TOPMed
CA870295 rs141829608	239	S>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA870296 rs141829608	239	S>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs1370300945 CA340457439	240	G>D		No	ClinGen gnomAD
rs138730701 CA870297	240	G>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs200886761 CA870298	242	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA870300 rs142137727	242	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs200886761 CA870299 COSM1687728	242	R>W	skin [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA340457503 rs1346236761	243	S>N		No	ClinGen gnomAD
rs754100738 CA870301	243	S>R		No	ClinGen ExAC gnomAD
rs1309462149 CA340457631	247	P>L		No	ClinGen gnomAD
rs759488228 CA870302	248	Y>*		No	ClinGen ExAC gnomAD
rs1273676937 CA340457742	250	H>D		No	ClinGen gnomAD
TCGA novel	250	H>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA340457813 rs1481917078	251	Y>C		No	ClinGen gnomAD
CA870303 rs765441271	252	S>F		No	ClinGen ExAC TOPMed gnomAD
rs1232781880 CA340457876	253	M>I		No	ClinGen TOPMed
rs753228860 CA870304	253	M>T		No	ClinGen ExAC gnomAD
rs776679689 CA870322	255	K>E		No	ClinGen ExAC TOPMed gnomAD
rs765388764 CA870324	256	K>*		No	ClinGen ExAC gnomAD
CA340458816 rs1243370786	256	K>N		No	ClinGen TOPMed gnomAD
CA870325 rs752883387	256	K>R		No	ClinGen ExAC gnomAD
CA340458842 rs1485878277	257	K>R		No	ClinGen gnomAD
rs1055674046 CA22755713	258	P>H		No	ClinGen Ensembl
rs532814421 CA870326	258	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA340458922 rs1292059982	260	E>*		No	ClinGen TOPMed
rs896896804 CA22755716	261	L>V		No	ClinGen TOPMed
CA870328 rs752122117	262	M>V		No	ClinGen ExAC gnomAD
CA340459007 rs1570141425	263	N>I		No	ClinGen Ensembl
rs1570141438 CA340459048	263	N>K		No	ClinGen Ensembl
CA22755732 rs1014146055	266	S>N		No	ClinGen Ensembl
CA340459150 rs1313170316	267	F>V		No	ClinGen TOPMed
CA340459182 rs1415208117	268	V>A		No	ClinGen gnomAD
CA870330 rs549458732	270	E>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1374472058 CA340459266	272	N>H		No	ClinGen TOPMed
rs1347044604 CA340459297	273	S>P		No	ClinGen gnomAD
rs374249337 CA870331	274	H>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs374249337 CA22755771	274	H>Y		No	ClinGen ESP ExAC TOPMed gnomAD
rs1320205047 CA340459509	278	K>T		No	ClinGen gnomAD
rs200136397 CA870333	279	H>D		No	ClinGen ExAC TOPMed gnomAD
rs200136397 CA870332	279	H>Y		No	ClinGen ExAC TOPMed gnomAD
CA340459561 rs1284601693	280	G>R		No	ClinGen gnomAD
rs771581871 CA870335	281	V>D		No	ClinGen ExAC TOPMed gnomAD
CA870334 rs747586144 COSM1343550	281	V>F	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA870336 rs777519817	286	P>A		No	ClinGen ExAC gnomAD
TCGA novel	286	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs747001366 CA870337	286	P>R		No	ClinGen ExAC gnomAD
CA22755805 rs777519817	286	P>S		No	ClinGen ExAC gnomAD
CA870338 rs770603510	287	R>*		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	287	R>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM173561 CA22755825 rs368171733	287	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP NCI-TCGA gnomAD
rs1382917340 CA340459856	288	N>I		No	ClinGen TOPMed
CA870339 rs763509919 COSM910958	289	P>L	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA340459872 rs1462355199	289	P>S		No	ClinGen gnomAD
CA340459862 rs1462355199	289	P>T		No	ClinGen gnomAD
CA870341 rs556765220	293	T>A		No	ClinGen ExAC gnomAD
CA870342 rs775859644	293	T>R		No	ClinGen ExAC TOPMed gnomAD
rs200750891 CA22755845	294	E>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA22755850 rs200750891	294	E>V		No	ClinGen TOPMed gnomAD
rs1158476924 CA340460000	295	R>G		No	ClinGen gnomAD
rs763070633 CA870343	296	I>V		No	ClinGen ExAC gnomAD
CA870344 rs764264704	298	W>G		No	ClinGen ExAC TOPMed gnomAD
CA340460104 rs764264704	298	W>R		No	ClinGen ExAC TOPMed gnomAD
rs774687338 CA870345	299	A>P		No	ClinGen ExAC gnomAD
rs1570141709 CA340460190	300	N>T		No	ClinGen Ensembl
CA340460198 rs1445541704	301	L>V		No	ClinGen gnomAD
rs756470759 CA870350	304	C>*		No	ClinGen ExAC TOPMed gnomAD
rs750862506 CA870349	304	C>Y		No	ClinGen ExAC
rs764809659 CA870351	305	P>H		No	ClinGen ExAC gnomAD
rs764809659 CA340460293	305	P>L		No	ClinGen ExAC gnomAD
rs563006764 CA870352	306	R>C		No	ClinGen 1000Genomes ExAC gnomAD
rs563006764 CA340460298	306	R>G		No	ClinGen 1000Genomes ExAC gnomAD
rs75313102 CA870355	306	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA870353 rs75313102	306	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA870354 rs75313102	306	R>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA340460323 rs1200679919	307	T>A		No	ClinGen gnomAD
rs1277471585 CA340460371	308	L>R		No	ClinGen gnomAD
CA340461017 rs1477181341	310	T>I		No	ClinGen gnomAD
CA340461038 rs1366840925	311	S>T		No	ClinGen TOPMed
CA870380 rs780043349	313	P>A		No	ClinGen ExAC gnomAD
rs1300389819 CA340461168	315	F>S		No	ClinGen gnomAD
CA870382 rs768989978	316	W>C		No	ClinGen ExAC gnomAD
rs1428862448 CA340461203	316	W>S		No	ClinGen gnomAD
CA340461236 rs1367345821	318	P>S		No	ClinGen gnomAD
TCGA novel	320	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA340461317 rs1328797634 COSM910959	321	K>N	endometrium [Cosmic]	No	ClinGen cosmic curated gnomAD
TCGA novel	323	C>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs772064684 CA870385	323	C>Y		No	ClinGen ExAC gnomAD
CA870387 rs761213662	325	P>S		No	ClinGen ExAC
CA22756626 COSM2152377 rs201728919	326	V>I	Variant assessed as Somatic; 0.0 impact. central_nervous_system [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP NCI-TCGA TOPMed gnomAD
CA340461432 rs1419445951	327	N>S		No	ClinGen TOPMed
rs925011044 CA22756630	327	N>Y		No	ClinGen TOPMed
CA340461506 rs1273167820	329	P>R		No	ClinGen gnomAD
CA870389 rs777041620	330	P>L		No	ClinGen ExAC TOPMed gnomAD
rs762512727 CA870390	331	F>L		No	ClinGen ExAC gnomAD
TCGA novel	333	L>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs148644942 CA22756648	334	T>N		No	ClinGen ESP gnomAD
rs981378042 CA22756646	334	T>P		No	ClinGen gnomAD
CA340461619 rs1190824136	336	K>N		No	ClinGen TOPMed gnomAD
CA340461630 CA870392 rs376296387	337	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs761339063 CA870393	338	S>*		No	ClinGen ExAC gnomAD
CA870394 rs767169780	339	G>D		No	ClinGen ExAC gnomAD
rs1166446334 CA340461677	339	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA340461751 rs1162521076	342	A>V		No	ClinGen gnomAD
rs75191355 CA870396	343	C>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA340461874 rs1434879806	347	M>I		No	ClinGen gnomAD
CA340461854 rs1320886227	347	M>L		No	ClinGen TOPMed gnomAD
CA870397 rs779990338	347	M>T		No	ClinGen ExAC TOPMed gnomAD
CA870412 rs562564414	352	P>A		No	ClinGen 1000Genomes ExAC gnomAD
rs1396957895 CA340462743	354	G>D		No	ClinGen gnomAD
CA870415 rs542343089	356	G>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
CA870414 rs531676172	356	G>S		No	ClinGen 1000Genomes ExAC gnomAD
rs144772293 CA870416	357	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs754760108 CA870417	357	R>H		No	ClinGen ExAC TOPMed gnomAD
CA22757794 rs1051071602	360	N>S		No	ClinGen TOPMed
CA340462903 rs1328498450	361	T>N		No	ClinGen gnomAD
CA22757798 rs1029231831	362	W>*		No	ClinGen Ensembl
CA870418 rs375175699	364	M>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs375175699 CA22757802	364	M>T		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	366	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	366	T>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs752943847 CA870419	368	D>H		No	ClinGen ExAC gnomAD
rs747029211 CA870422	370	R>P		No	ClinGen ExAC gnomAD
rs747029211 CA340463162	370	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs146890884 CA870421	370	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA340463185 rs1182758223	371	Q>R		No	ClinGen gnomAD
rs781628316 CA870424	372	R>*		No	ClinGen ExAC TOPMed gnomAD
rs989208592 CA22757848	372	R>Q		No	ClinGen Ensembl
rs143295653 CA870426	374	R>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA870427 rs143295653	374	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs747831975 CA870428	374	R>P		No	ClinGen ExAC TOPMed gnomAD
CA870431 rs148287584	376	L>Q		No	ClinGen ESP ExAC gnomAD
CA870430 rs373489791	376	L>V		No	ClinGen ESP ExAC gnomAD
CA22757901 rs4999211	377	F>S		No	ClinGen Ensembl
CA340463344 rs1302661985	380	G>V		No	ClinGen gnomAD
CA870432 rs766014289	382	K>*		No	ClinGen ExAC gnomAD
CA22757920 rs927900802	383	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1289451179 CA340463416	384	Y>C		No	ClinGen gnomAD
CA340463427 rs1166127476	385	L>F		No	ClinGen TOPMed gnomAD
CA340463547 rs376402163	390	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA870435 rs148430708	390	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA870434 rs376402163	390	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs752503910 CA870436	391	D>E		No	ClinGen ExAC TOPMed gnomAD
CA22757934 rs886409113	391	D>N		No	ClinGen gnomAD
rs1205793692 CA340463600	392	M>I		No	ClinGen TOPMed gnomAD
CA340463595 rs1557789191	392	M>L		No	ClinGen Ensembl
rs764247458 CA340463598	392	M>R		No	ClinGen ExAC TOPMed gnomAD
CA870438 rs764247458	392	M>T		No	ClinGen ExAC TOPMed gnomAD
CA340463613 rs1286441726	393	L>F		No	ClinGen TOPMed
CA340463637 rs1192395823	394	M>I		No	ClinGen TOPMed gnomAD
CA870440 rs757287929	394	M>V		No	ClinGen ExAC TOPMed gnomAD
CA340467798 rs1432453292	397	R>G		No	ClinGen TOPMed
CA340467816 rs1334607865	397	R>S		No	ClinGen TOPMed gnomAD
CA340467853 rs1358311811	400	P>A		No	ClinGen gnomAD
CA340467854 rs1412874339	400	P>Q		No	ClinGen gnomAD
CA870498 rs574255393	403	K>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA22773482 rs1009557074	404	G>E		No	ClinGen TOPMed gnomAD
CA340467905 rs1009557074	404	G>V		No	ClinGen TOPMed gnomAD
rs1187364807 CA340467917	405	K>*		No	ClinGen TOPMed
rs766354000 CA870500	407	P>T		No	ClinGen ExAC gnomAD
rs1279793701 CA340467960	408	P>L		No	ClinGen TOPMed gnomAD
CA340467953 rs759695474	408	P>S		No	ClinGen ExAC TOPMed
CA870502 rs759695474	408	P>T		No	ClinGen ExAC TOPMed
CA340467971 rs1206156906	410	V>M		No	ClinGen TOPMed
CA340467995 rs1209435728	411	D>G		No	ClinGen gnomAD
CA870505 rs376151695	412	Y>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA22773494 rs1008117826	413	N>S		No	ClinGen TOPMed
CA340468051 rs1181508476	414	S>L		No	ClinGen gnomAD
TCGA novel	416	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1479141822 CA340468086	417	T>S		No	ClinGen TOPMed gnomAD
rs1173320913 CA340468093	418	P>S		No	ClinGen gnomAD

No associated diseases with Q3ZCV2

1 regional properties for Q3ZCV2

Type	Name	Position	InterPro Accession
domain	Luciferase-like domain	1 - 320	IPR011251

Functions

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

No GO annotations of cellular component

Name	Definition
No GO annotations for cellular component

No GO annotations of molecular function

Name	Definition
No GO annotations for molecular function

No GO annotations of biological process

Name	Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MRESQDAAGA	HGWNRVGSTA	TKWFTGAPFG	VQSHRFDISA	VYPNWKKFST	FTEAPYSTRY
70	80	90	100	110	120
STQVSHIGPG	TYSSKETCFS	KKKLMKEVDT	GWAKAQEATR	LTQLPHFQYQ	AIMKEKRLKE
130	140	150	160	170	180
QKLGPGSYNL	KDFLEQLREK	PCSTRGLLSS	GEVRFRGLTG	NYYPGPGNYG	EKGNPYTKLE
190	200	210	220	230	240
ENAWNRSHSE	GLMCRMSNKP	HPRPHQGSGL	GPGTYFFKSD	LETYVARSVG	TRGPYDTFSG
250	260	270	280	290	300
DRSKPLPYGH	YSMQKKKPRE	LMNFKSFVEE	LNSHHNKKHG	VFSKLPRNPK	TPTERIYWAN
310	320	330	340	350	360
LSQCPRTLAT	SGPSFWLPQE	KKCKPVNQPP	FLLTSKGSGA	KACQMIMGSW	NPVGVGRYLN
370	380	390	400	410
TWLMETKDRR	QRYRSLFLSG	SKRYLSDLAR	DMLMQERITP	FTKGKCPPTV	DYNSDPTP