Q3ZCL3

PR
Gene name
NMI
Protein name
N-myc-interactor
Names
Nmi, N-myc and STAT interactor
Species
Bos taurus (Bovine)
KEGG Pathway
bta:511280
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-110 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q3ZCL3

Entry ID Method Resolution Chain Position Source
AF-Q3ZCL3-F1 Predicted AlphaFoldDB

No variants for Q3ZCL3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q3ZCL3

No associated diseases with Q3ZCL3

3 regional properties for Q3ZCL3

Type Name Position InterPro Accession
domain Nmi/IFP 35 domain 106 - 193 IPR009909-1
domain Nmi/IFP 35 domain 204 - 293 IPR009909-2
domain Nmi/IFP 35 domain, N-terminal 30 - 105 IPR009938

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • Secreted
  • Cytoplasmic NMI localizes in punctate granular structures
  • Nuclear localization increased following IFN-alpha treatment
  • Extracelullar following secretion by macrophage
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name Definition
transcription coregulator activity A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.

10 GO annotations of biological process

Name Definition
interferon-gamma-mediated signaling pathway The series of molecular signals initiated by interferon-gamma binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Interferon gamma is the only member of the type II interferon found so far.
macrophage activation involved in immune response A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
negative regulation of cell population proliferation Any process that stops, prevents or reduces the rate or extent of cell proliferation.
negative regulation of innate immune response Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response.
negative regulation of NIK/NF-kappaB signaling Any process that stops, prevents or reduces the frequency, rate or extent of NIK/NF-kappaB signaling.
positive regulation of inflammatory response Any process that activates or increases the frequency, rate or extent of the inflammatory response.
positive regulation of innate immune response Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.
positive regulation of NIK/NF-kappaB signaling Any process that activates or increases the frequency, rate or extent of NIK/NF-kappaB signaling.
toll-like receptor 4 signaling pathway The series of molecular signals initiated by a ligand binding to toll-like receptor 4.
transcription by RNA polymerase II The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O35309 Nmi N-myc-interactor Mus musculus (Mouse) PR
10 20 30 40 50 60
MSADEDNKEQ VLKECEQAEE IMKDKQNQKL ISEITKENIQ LKEEIKKLEA ELQETTRTSQ
70 80 90 100 110 120
INEDIPETKI KFTSVENPES DSEFSDISYS CQVSSKVPYE LQKGQALITF EKEEVAQNVI
130 140 150 160 170 180
RMEYHHVQVQ NENVMLTANP VSLNSGVKFQ VHVGVSKMKI NVTDIPDELP ESQMRDKLEL
190 200 210 220 230 240
SFSKSRNGGG EVEYVEYNKQ TRSALITFVE SGVADKILKM KDYPLYINQN CHRVTVYPYT
250 260 270 280 290 300
ETHLKKFQVF SGVSKRTVLL TGLKHLQTTD EEVVEDFISI HFQREKNGGG EVEVVKCSLG
QPHTAYFEE