Q3ZAE4

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Dehalococcoides mccartyi (strain ATCC BAA-2266 / KCTC 15142 / 195) (Dehalococcoides ethenogenes (strain 195))
KEGG Pathway
det:DET0050
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

180-250 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q3ZAE4

Entry ID Method Resolution Chain Position Source
AF-Q3ZAE4-F1 Predicted AlphaFoldDB

No variants for Q3ZAE4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q3ZAE4

No associated diseases with Q3ZAE4

4 regional properties for Q3ZAE4

Type Name Position InterPro Accession
domain DHHA1 domain 731 - 869 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 650 - 695 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 6 - 553 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 2 - 708 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MFSSDELREN YLKFFEEKGH KRIASSSLIP HNDPTLLLTT AGMVQFKPYY LGVAKPENSR
70 80 90 100 110 120
MTSCQKCFRT TDIESVGDAS HLTMFEMLGN FSIGNYFKKE AIAWAWEYVT QRLNIPAEKL
130 140 150 160 170 180
WVTVYLDDDE AIALWKEQGV PEGRIVRLGA ADNFWGPAGD SGPCGPCSEI HYDFGQEMGC
190 200 210 220 230 240
GKADCNPSCK CGRFCEIWNL VFVQFNQDKS GKRQNLPAPS IDTGMGLERL TILMQFRKNV
250 260 270 280 290 300
YETDIFAPVI EKACQLSGRQ YGIDAETDKA LRIVSEHSRG ITFLIADGVI PDKAGRGYVL
310 320 330 340 350 360
RRLLRRAVLF GRRLGLEKPF LVDMAGAVIA RMSGIYPELN KRQAYVLEMI ASEEARFSET
370 380 390 400 410 420
LATGLELLEE IVRQTKGGQI SGQDAFKLYD TYGFPVEMTT EIAAERGLSV DLGGFEAEME
430 440 450 460 470 480
VQRTKARSSR KFSFDAAATA EAVKNMRHGE KTCFVGYELT RQKSTIMDIL TEGGSVDSIE
490 500 510 520 530 540
EGDEASIVLD ESPFYAEMGG QVGDTGEIIT GGGRFEVKNT LHLPNGVFLH QGRVISGCLK
550 560 570 580 590 600
IAETAAAHID EERRRDIARN HTATHILQTA LRQVLGEQVQ QRGSVVTPER LRFDFSHLKP
610 620 630 640 650 660
MTKDEIRRAE EFVNDKIRRN LPVYAEEMPY RHALEEGVTA LFGEKYGDRV RVLRVGRPAV
670 680 690 700 710 720
SAELCGGTHV SASGEISLFK IVSESSVGAG LRRIEAVTGR EAEAYINLQQ DSLSELSGML
730 740 750 760 770 780
EAAPEESPRK LAELKEEIDT LKKTVQNLER QMSRGEAEEL LSKAEDYKGI KLLVSRMTSV
790 800 810 820 830 840
NADTLHETAD FLRDKLGSGI IVLGTVSEDK PFFLCMVTPD LIEKGYHAGN IVKKLSQIAG
850 860 870
GGGGGKPNMA QGGGRDKAKL DEALQAVKGM L