Q3YYG6

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Shigella sonnei (strain Ss046)
KEGG Pathway
ssn:SSON_2841
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

398-468 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q3YYG6

Entry ID Method Resolution Chain Position Source
AF-Q3YYG6-F1 Predicted AlphaFoldDB

No variants for Q3YYG6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q3YYG6

No associated diseases with Q3YYG6

4 regional properties for Q3YYG6

Type Name Position InterPro Accession
domain DHHA1 domain 732 - 871 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 653 - 696 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 7 - 556 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 3 - 709 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSKSTAEIRQ AFLDFFHSKG HQVVASSSLV PHNDPTLLFT NAGMNQFKDV FLGLDKRNYS
70 80 90 100 110 120
RATTSQRCVR AGGKHNDLEN VGYTARHHTF FEMLGNFSFG DYFKHDAIQF AWELLTSEKW
130 140 150 160 170 180
FALPKERLWV TVYESDDEAY EIWEKEVGIP RERIIRIGDN KGAPYASDNF WQMGDTGPCG
190 200 210 220 230 240
PCTEIFYDHG DHIWGGPPGS PEEDGDRYIE IWNIVFMQFN RQADGTMEPL PKPSVDTGMG
250 260 270 280 290 300
LERIAAVLQH VNSNYDIDLF RTLIQAVAKV TGATDLSNKS LRVIADHIRS CAFLIADGVM
310 320 330 340 350 360
PSNENRGYVL RRIIRRAVRH GNMLGAKETF FYKLVGPLID VMGSAGEDLK RQQAQVEQVL
370 380 390 400 410 420
KTEEEQFART LERGLALLDE ELAKLSGDTL DGETAFRLYD TYGFPVDLTA DVCRERNIKV
430 440 450 460 470 480
DEAGFEAAME EQRRRAREAS GFGADYNAMI RVDSASEFKG YDHLELNGKV TALFVDGKAV
490 500 510 520 530 540
DAINAGQEAV VVLDQTPFYA ESGGQVGDKG ELKGANFSFA VEDTQKYGQA IGHIGKLAAG
550 560 570 580 590 600
SLKVGDAVQA DVDEARRARI RLNHSATHLM HAALRQVLGT HVSQKGSLVN DKVLRFDFSH
610 620 630 640 650 660
NEAMKPEEIR AVEDLVNAQI RRNLPIETNI MDLEAAKAKG AMALFGEKYD ERVRVLSMGD
670 680 690 700 710 720
FSTELCGGTH ASRTGDIGLF RIISESGTAA GVRRIEAVTG EGAITTVHAD SDRLSEVAHL
730 740 750 760 770 780
LKGDSNNLAD KVRSVLERTR QLEKELQQLK EQAAAQESAN LSSKAIDVNG VKLLVSELSG
790 800 810 820 830 840
VEPKMLRTMV DDLKNQLGST IIVLATVAEG KVSLIAGVSK DVTDRVKAGE LIGMVAQQVG
850 860 870
GKGGGRPDMA QAGGTDAAAL PAALASVKGW VSAKLQ