Q3YRP2

PR
Gene name
dapB
Protein name
4-hydroxy-tetrahydrodipicolinate reductase
Names
HTPA reductase
Species
Ehrlichia canis (strain Jake)
KEGG Pathway
ecn:Ecaj_0579
EC number
1.17.1.8: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

154-224 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q3YRP2

Entry ID Method Resolution Chain Position Source
AF-Q3YRP2-F1 Predicted AlphaFoldDB

No variants for Q3YRP2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q3YRP2

No associated diseases with Q3YRP2

3 regional properties for Q3YRP2

Type Name Position InterPro Accession
domain Dihydrodipicolinate reductase, N-terminal 4 - 124 IPR000846
domain Dihydrodipicolinate reductase, C-terminal 128 - 263 IPR022663
conserved_site Dihydrodipicolinate reductase, conserved site 149 - 166 IPR022664

Functions

Description
EC Number 1.17.1.8 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
4-hydroxy-tetrahydrodipicolinate reductase Catalysis of the reaction: (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+.
NAD binding Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.
NADP binding Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH.
oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP.

2 GO annotations of biological process

Name Definition
diaminopimelate biosynthetic process The chemical reactions and pathways resulting in the formation of diaminopimelate, both as an intermediate in lysine biosynthesis and as a component (as meso-diaminopimelate) of the peptidoglycan of Gram-negative bacterial cell walls.
lysine biosynthetic process via diaminopimelate The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTKVNIGIVG CLGKQGKRLV AEISASPNAQ VSAGLVRPGN PYVGQVLGEI VGCNCSAKAI
70 80 90 100 110 120
DSLEHLFDVS DIVVEFTNPQ TLLECIKMAE SKKKPLLSGT TGPAATEMVF EDYIKNIPFL
130 140 150 160 170 180
WTTNVSFGVN ILAKLVEEAA RKLFDYDIEV WEMHHRYKKD SPSGTSLILG RAAAKGRNVP
190 200 210 220 230 240
FKKAQYVSGT PQEARQDVNT IGYAVSRGGS DLSDHRIMFV SDEEMIDFNH RTLNKNLYAK
250 260
GALKAALWLV KQPPGVYTMS DMMAAAE