Q3UUY6
PR
Gene name |
Prom2 (Proml2) |
Protein name |
Prominin-2 |
Names |
PROM-2, Prominin-like protein 2, mPROML2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:192212 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q3UUY6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q3UUY6-F1 | Predicted | AlphaFoldDB |
41 variants for Q3UUY6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388583123 | 3 | R>C | No | EVA | |
| rs27434661 | 5 | P>A | No | EVA | |
| rs3410768458 | 9 | V>M | No | EVA | |
| rs3388593058 | 49 | E>K | No | EVA | |
| rs3388576407 | 61 | N>K | No | EVA | |
| rs226312361 | 135 | R>H | No | EVA | |
| rs3388589895 | 144 | H>D | No | EVA | |
| rs27434672 | 156 | I>T | No | EVA | |
| rs3388590196 | 161 | T>I | No | EVA | |
| rs3388585541 | 200 | L>Q | No | EVA | |
| rs224727576 | 209 | R>Q | No | EVA | |
| rs220966743 | 240 | R>Q | No | EVA | |
| rs263142647 | 281 | R>W | No | EVA | |
| rs214744460 | 291 | R>Q | No | EVA | |
| rs3388590202 | 293 | R>H | No | EVA | |
| rs27434678 | 316 | G>S | No | EVA | |
| rs3388593003 | 358 | N>I | No | EVA | |
| rs3388589957 | 367 | A>V | No | EVA | |
| rs33431985 | 411 | R>C | No | EVA | |
| rs3388589972 | 415 | Y>N | No | EVA | |
| rs3388589915 | 443 | C>F | No | EVA | |
| rs3388590234 | 479 | V>A | No | EVA | |
| rs27434689 | 495 | V>A | No | EVA | |
| rs254021682 | 534 | Y>H | No | EVA | |
| rs3388587224 | 541 | N>D | No | EVA | |
| rs266081885 | 544 | I>V | No | EVA | |
| rs3388576399 | 581 | K>N | No | EVA | |
| rs212921495 | 587 | Q>R | No | EVA | |
| rs27434700 | 588 | S>N | No | EVA | |
| rs3388583490 | 618 | I>F | No | EVA | |
| rs3388589970 | 631 | V>M | No | EVA | |
| rs3388592290 | 639 | L>M | No | EVA | |
| rs33360083 | 660 | R>Q | No | EVA | |
| rs3388591275 | 708 | S>T | No | EVA | |
| rs237466096 | 711 | R>H | No | EVA | |
| rs3388591333 | 725 | R>W | No | EVA | |
| rs27434717 | 753 | R>H | No | EVA | |
| rs3388585571 | 793 | L>I | No | EVA | |
| rs257846084 | 800 | A>T | No | EVA | |
| rs3388588821 | 801 | V>A | No | EVA | |
| rs3391908417 | 829 | R>T | No | EVA |
No associated diseases with Q3UUY6
4 regional properties for Q3UUY6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | C2 domain | 22 - 147 | IPR000008 |
| domain | EF-hand domain | 179 - 246 | IPR002048 |
| binding_site | EF-Hand 1, calcium-binding site | 188 - 200 | IPR018247-1 |
| binding_site | EF-Hand 1, calcium-binding site | 224 - 236 | IPR018247-2 |
Functions
14 GO annotations of cellular component
| Name | Definition |
|---|---|
| apical plasma membrane | The region of the plasma membrane located at the apical end of the cell. |
| basolateral plasma membrane | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. |
| cell projection | A prolongation or process extending from a cell, e.g. a flagellum or axon. |
| cell surface | The external part of the cell wall and/or plasma membrane. |
| ciliary membrane | The portion of the plasma membrane surrounding a cilium. |
| cilium | A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body. |
| cytoplasmic vesicle | A vesicle found in the cytoplasm of a cell. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| membrane raft | Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions. |
| microspike | A dynamic, actin-rich projection extending from the surface of a migrating animal cell. |
| microvillus | Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells. |
| microvillus membrane | The portion of the plasma membrane surrounding a microvillus. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| prominosome | An extracellular membrane-bounded vesicle that contains prominin proteins (in mouse Prom1/CD33 or Prom2) and are found in body fluids including ventricular fluid, saliva, urine and seminal fluid. In the ventricular fluid of the developing mouse brain two major classes of these particles have been observed (P2 particles of 500-1000 nm and P4 particles of 50-80 nm) which likely originate from microvilli, primary cilia and/or the midbody of neuroepithelial cells. The physiological role is not known. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| cholesterol binding | Binding to cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| negative regulation of caveolin-mediated endocytosis | Any process that stops, prevents or reduces the frequency, rate or extent of caveolin-mediated endocytosis. |
| negative regulation of pinocytosis | Any process that stops, prevents, or reduces the frequency, rate or extent of pinocytosis. Pinocytosis is the process in which cells take in liquid material from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, formed by invagination of the plasma membrane. These vesicles then move into the cell and pass their contents to endosomes. |
| positive regulation of cell projection organization | Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections. |
| positive regulation of protein phosphorylation | Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein. |
| regulation of GTPase activity | Any process that modulates the rate of GTP hydrolysis by a GTPase. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8N271 | PROM2 | Prominin-2 | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTRSPGLMVP | LLGLSLGLAL | SLPEAVTDDC | GSLGRVEHLA | FARVPRTREL | APLVRASGPL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NSLYGTVRRF | LSVVQLNPFP | AELIKTLLND | PSSVKTDEVV | RYEAGYVVCA | VIAGLYLLLV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PITGLCFCCC | RCRQRCGGRV | KTEHKAMACE | RGTLMIFLLL | TTLVLLIGMV | CAFATNQHTH |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SQTGPSVKAV | PETLLSLRGL | VSDVPEELRA | IAEQFSVPQK | QVSKELDGVG | ENLGNVIHNR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LKSTVYPVLA | SVHSLGQALQ | VSIDHLRALN | TTSVELQEAQ | RHLEPPVQAH | RERLLALLQD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SWCHEENCKR | VLSQAGALQL | GADFSQTPPV | DDVLHRLKDV | PETNFSSMVQ | EEKATFNNLP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LLVQVQAVSV | VKDVKKALAE | QPEGLRMLAQ | AFPGSEAASR | WSQALEGLEQ | RSRPYLQEVQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QYETYRWILG | CVLCSAILLV | VICNLLGLSL | GIWGLFARED | PSHSETKGEA | GARLLMAGVA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| FSFLFAVPLI | LLVFVTFLVG | GNVQTLVCRS | WESGELYEFA | DTPGNLPPSM | NLSYLLGLKK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| NISIVQAYRQ | CKAGAVLWKV | LQLNDSYDLD | KHLDIKQYTH | KIQQELQSFQ | VDLKELDLLS |
| 610 | 620 | 630 | 640 | 650 | 660 |
| PTARQDLEAL | QRSGLEKIHY | RGFLVQIQKP | VVNTDMWQLA | QELEGLAQAQ | NDSLLRQQLR |
| 670 | 680 | 690 | 700 | 710 | 720 |
| EEARELRSLY | QEKVVPQESL | VTKLNFSVKT | LESLAPSLQV | NTSDFLDSVT | RLKGELPVQI |
| 730 | 740 | 750 | 760 | 770 | 780 |
| NHILRNATEC | FLTREMGYFS | QYVTWVRAEV | TQRIATCQPF | STALDNGHVI | LCDMMADPWN |
| 790 | 800 | 810 | 820 | 830 | |
| AFWFCLGWCT | FFLIPSIIFA | VKTSKYFRPI | RKRLSSTSSE | ETQLFHIPRV | TSLKL |