Q3UJP5

PR
Gene name
Cfap418
Protein name
Cilia- and flagella-associated protein 418
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:67157
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-82 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q3UJP5

Entry ID Method Resolution Chain Position Source
AF-Q3UJP5-F1 Predicted AlphaFoldDB

10 variants for Q3UJP5

Variant ID(s) Position Change Description Diseaes Association Provenance
rs234988921 33 D>G No EVA
rs252900390 47 Q>R No EVA
rs3388670172 62 D>E No EVA
rs3388676638 67 L>R No EVA
rs260386497 85 F>S No EVA
rs3388661930 123 N>S No EVA
rs3388672960 157 F>L No EVA
rs3388667730 180 A>E No EVA
rs3388671928 187 W>L No EVA
rs3388659166 207 G>S No EVA

No associated diseases with Q3UJP5

No regional properties for Q3UJP5

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q3UJP5

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Photoreceptor inner segment
  • In the retina, located at the base of the primary cilium (PubMed:22177090)
  • Expressed throughout photoreceptors cell body including the basal body, inner segment and synaptic terminus, but not in the outer segment (at the protein level)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
cell junction A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella.
ciliary base Area of the cilium (also called flagellum) where the basal body and the axoneme are anchored to the plasma membrane. The ciliary base encompasses the distal part of the basal body, transition fibers and transition zone and is structurally and functionally very distinct from the rest of the cilium. In this area proteins are sorted and filtered before entering the cilium, and many ciliary proteins localize specifically to this area.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
photoreceptor inner segment The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

1 GO annotations of biological process

Name Definition
photoreceptor cell morphogenesis The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAKDLDELLD EVETKFCRLD PLRLDLGERP KGDGGGGSHS GDRNGAQEKE TLRSTETFKK
70 80 90 100 110 120
EDDLDSLINE IFEEPDFDRK SFQKFKSKSS SNTCVRAPMQ GVSKSCSPVY LSGSAIPCGI
130 140 150 160 170 180
GTNTSQRACD RLRCVACDFR IVSYNDYMWD KSCDYLFFRN NMPEFHKLKT KLIEKKGARA
190 200
YACQCSWRTV EELTDLQTDH QLRWVCGKH