AiPD: Autoinhibited Protein Database

Gene name	Trmt10c
Protein name	tRNA methyltransferase 10 homolog C
Names	Mitochondrial ribonuclease P protein 1, Mitochondrial RNase P protein 1, RNA (guanine-9-)-methyltransferase domain-containing protein 1, mRNA methyladenosine-N(1)-methyltransferase, tRNA (adenine(9)-N(1))-methyltransferase, tRNA (guanine(9)-N(1))-methyltransferase
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:52575
EC number	2.1.1.218: Methyltransferases
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

37-113 (Predicted disordered autoinhibitory region) PR

37-113 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q3UFY8-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389414089	17	P>T	No	EVA
rs3389422629	26	H>Y	No	EVA
rs252430637	40	A>T	No	EVA
rs259719058	48	K>Q	No	EVA
rs3389387905	72	E>K	No	EVA
rs49722867	88	S>L	No	EVA
rs3389430078	99	L>I	No	EVA
rs51689527	111	D>E	No	EVA
rs3389336152	136	K>Q	No	EVA
rs223795858	137	A>V	No	EVA
rs3389400536	150	E>*	No	EVA
rs3389414168	169	Q>K	No	EVA
rs262458996	191	V>A	No	EVA
rs3389428155	216	Q>H	No	EVA
rs3389379525	236	F>I	No	EVA
rs3389430058	266	L>V	No	EVA
rs3406911367	268	A>S	No	EVA
rs3406985561	270	E>G	No	EVA
rs3405295894	271	K>E	No	EVA
rs3407312668	271	K>N	No	EVA
rs3406398056	272	S>F	No	EVA
rs3407002514	273	P>S	No	EVA
rs3389428137	292	V>I	No	EVA
rs245549677	326	I>L	No	EVA
rs3389414108	335	K>*	No	EVA
rs3389387950	336	Y>F	No	EVA
rs4188221	363	N>S	No	EVA
rs222480640	408	N>S	No	EVA
rs250260415	409	V>A	No	EVA

Type	Name	Position	InterPro Accession
domain	tRNA methyltransferase TRMD/TRM10-type domain	207 - 375	IPR016009
domain	tRNA methyltransferase 10 homologue C, SAM-dependent MTase TRM10-type	198 - 375	IPR025812
domain	tRNA methyltransferase TRM10-type domain	186 - 378	IPR028564

		Description
EC Number	2.1.1.218	Methyltransferases
Subcellular Localization	Mitochondrion matrix, mitochondrion nucleoid
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
mitochondrial nucleoid	The region of a mitochondrion to which the DNA is confined.
mitochondrial ribonuclease P complex	A ribonuclease P complex located in the mitochondrion of a eukaryotic cell, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. The subunit composition of mitochondrial ribonuclease P complexes varies between species. The complex contains a single RNA molecule and a single protein molecule in yeast (PMID:12045094), but comprises three proteins and lacks an RNA component in humans.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
tRNA methyltransferase complex	A multimeric protein complex involved in the methylation of specific nucleotides in tRNA.

Name	Definition
identical protein binding	Binding to an identical protein or proteins.
mRNA (adenine-N1-)-methyltransferase activity	Catalysis of the reaction: S-adenosyl-L-methionine + adenine in mRNA = S-adenosyl-L-homocysteine + N(1)-methyladenine in mRNA.
tRNA (adenine-N1-)-methyltransferase activity	Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methyladenine.
tRNA (guanine(9)-N(1))-methyltransferase activity	Catalysis of the reaction: S-adenosyl-L-methionine + guanine(9) in tRNA = N(1)-methylguanine(9) in tRNA + S-adenosyl-L-homocysteine.
tRNA (guanine-N1-)-methyltransferase activity	Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methylguanine.
tRNA binding	Binding to a transfer RNA.

Name	Definition
mitochondrial RNA 5'-end processing	Any process involved in forming the mature 5' end of an RNA molecule transcribed from a mitochondrial genome; occurs in the mitochondrion.
mitochondrial tRNA 3'-end processing	The process in which the 3' end of a pre-tRNA molecule is converted to that of a mature tRNA in the mitochondrion.
mitochondrial tRNA 5'-end processing	The process in which the 5' end of a pre-tRNA molecule is converted to that of a mature tRNA in the mitochondrion.
mitochondrial tRNA methylation	The posttranscriptional addition of methyl groups to specific residues in a mitochondrial tRNA molecule.
mitochondrial tRNA processing	The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group, in the mitochondrion.
mRNA methylation	The posttranscriptional addition of methyl groups to specific residues in an mRNA molecule.
positive regulation of mitochondrial translation	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins