AiPD: Autoinhibited Protein Database

Gene name	Garem1 (Fam59a, Garem, Gm944, Kiaa4238)
Protein name	GRB2-associated and regulator of MAPK protein
Names	GRB2-associated and regulator of MAPK1
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:381126
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

394-811 (Predicted disordered autoinhibitory region) PR

394-811 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q3UFT3-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3408131549	12	K>E	No	EVA
rs3408477203	12	K>M	No	EVA
rs3408477195	29	T>I	No	EVA
rs3408311844	30	Y>*	No	EVA
rs3406439647	31	R>*	No	EVA
rs3389483686	63	T>S	No	EVA
rs3389456922	74	Y>F	No	EVA
rs3389436959	152	D>E	No	EVA
rs3389498164	186	S>F	No	EVA
rs3389469647	192	K>*	No	EVA
rs254747371	216	K>R	No	EVA
rs3408130489	224	P>S	No	EVA
rs47927011	225	L>M	No	EVA
rs3408353089	226	E>G	No	EVA
rs3389498198	232	G>W	No	EVA
rs3389401145	245	L>F	No	EVA
rs3389498118	260	Y>C	No	EVA
rs3389489289	271	Y>C	No	EVA
rs3389469669	290	N>K	No	EVA
rs3406437220	316	D>G	No	EVA
rs3389483099	316	D>N	No	EVA
rs3408242858	317	M>L	No	EVA
rs3408664251	318	W>G	No	EVA
rs3408130503	319	P>T	No	EVA
rs3389490910	330	C>G	No	EVA
rs3389436968	359	K>R	No	EVA
rs1135341283	361	R>C	No	EVA
rs1135341283	361	R>S	No	EVA
rs3389498186	362	C>S	No	EVA
rs3389483644	367	H>L	No	EVA
rs3389436995	382	S>T	No	EVA
rs1132661584	385	R>L	No	EVA
rs3389505937	402	N>I	No	EVA
rs1133982948	404	H>Q	No	EVA
rs3389490866	407	R>G	No	EVA
rs3389493753	423	Y>H	No	EVA
rs3389500989	440	E>K	No	EVA
rs3408382021	457	W>R	No	EVA
rs264498598	465	R>H	No	EVA
rs3389500910	476	S>C	No	EVA
rs3389483079	480	T>S	No	EVA
rs3389493760	496	T>A	No	EVA
rs228443942	510	A>T	No	EVA
rs3389456931	517	P>S	No	EVA
rs1133792286	528	R>Q	No	EVA
rs3389500971	562	R>G	No	EVA
rs3408353116	581	Q>L	No	EVA
rs3389483035	594	C>R	No	EVA
rs3389490412	598	T>I	No	EVA
rs1132523440	664	C>S	No	EVA
rs3389505953	678	S>N	No	EVA
rs3389446992	706	S>F	No	EVA
rs240148961	713	A>T	No	EVA
rs3389483040	746	L>Q	No	EVA
rs3408353125	787	L>P	No	EVA
rs50106372	829	V>F	No	EVA
rs50106372	829	V>I	No	EVA
rs3389490871	870	N>Y	No	EVA
rs864279974	875	K>E	No	EVA
rs864284247	875	K>R	No	EVA

Type	Name	Position	InterPro Accession
domain	CABIT domain	32 - 312	IPR025946

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
No GO annotations for cellular component

Name	Definition
proline-rich region binding	Binding to a proline-rich region, i.e. a region that contains a high proportion of proline residues, in a protein.

Name	Definition
cellular response to epidermal growth factor stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus.
epidermal growth factor receptor signaling pathway	The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
positive regulation of cell division	Any process that activates or increases the frequency, rate or extent of cell division.
positive regulation of cell population proliferation	Any process that activates or increases the rate or extent of cell proliferation.
positive regulation of ERK1 and ERK2 cascade	Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q75VX8	GAREM2	GRB2-associated and regulator of MAPK protein 2	Homo sapiens (Human)	PR
Q9H706	GAREM1	GRB2-associated and regulator of MAPK protein 1	Homo sapiens (Human)	PR