Q3UA16
Gene name |
Spc25 (Spbc25) |
Protein name |
Kinetochore protein Spc25 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:66442 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q3UA16
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q3UA16-F1 | Predicted | AlphaFoldDB |
17 variants for Q3UA16
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388555690 | 8 | L>I | No | EVA | |
| rs3391739151 | 39 | K>M | No | EVA | |
| rs3391589393 | 40 | D>E | No | EVA | |
| rs3391734464 | 42 | M>L | No | EVA | |
| rs3388553418 | 45 | F>L | No | EVA | |
| rs27976143 | 60 | T>A | No | EVA | |
| rs27976143 | 60 | T>S | No | EVA | |
| rs582356275 | 61 | E>D | No | EVA | |
| rs578988409 | 64 | L>R | No | EVA | |
| rs3388554678 | 91 | V>I | No | EVA | |
| rs27976154 | 103 | A>T | No | EVA | |
| rs3388557280 | 110 | E>K | No | EVA | |
| rs27976155 | 116 | R>K | No | EVA | |
| rs27976167 | 135 | K>R | No | EVA | |
| rs3388555764 | 183 | E>K | No | EVA | |
| rs3388560048 | 189 | S>G | No | EVA | |
| rs3388556833 | 207 | N>T | No | EVA |
No associated diseases with Q3UA16
1 regional properties for Q3UA16
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Chromosome segregation protein Spc25, C-terminal | 151 - 220 | IPR013255 |
Functions
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| kinetochore | A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules. |
| Ndc80 complex | An outer kinetochore protein complex that is part of the KMN kinetochore network (also known as the NMS complex) providing the platform with which the plus ends of spindle microtubules directly interact to form stable kinetochore-microtubule attachments. A common subunit nomenclature is used from yeast to human: Ndc80, Nuf2, Spc24, and Spc25. |
| NMS complex | A supercomplex formed by the association of two subcomplexes (known as MIND and Ndc80 in Schizosaccharomyces) with additional proteins at the kinetochores of condensed nuclear chromosomes. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| attachment of spindle microtubules to kinetochore | The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex. |
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| chromosome segregation | The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. |
| mitotic spindle assembly checkpoint signaling | A signal transduction process that contributes to a mitotic cell cycle spindle assembly checkpoint, that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle. |
| mitotic spindle organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGEDELALLN | QSINEFGDKF | RNRLDDNHSQ | VLGLRDAFKD | SMKAFSEKMS | LKLKEEERMT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EMILEYKNQL | CKQNKLIQEK | KENVLKMIAE | VKGKEQESEE | LTAKIQELKE | EYARKRETIS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TANKANEERL | KGLQKSADLY | RDYLGLEIRK | IHGNKLQFIF | TSIDPKNPES | PYMFSMSINE |
| 190 | 200 | 210 | 220 | ||
| AKEYEVYDSS | PHLECLAEFQ | EKVRKTNNFS | AFLANIRKAF | IAKVHN |