Q3U2S4
PR
Gene name |
Otud5 |
Protein name |
OTU domain-containing protein 5 |
Names |
Deubiquitinating enzyme A, DUBA |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:54644 |
EC number |
3.4.19.12: Omega peptidases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q3U2S4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q3U2S4-F1 | Predicted | AlphaFoldDB |
25 variants for Q3U2S4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3409644573 | 71 | L>R | No | EVA | |
| rs3389544750 | 155 | A>V | No | EVA | |
| rs3408437448 | 187 | R>P | No | EVA | |
| rs3389562594 | 255 | A>D | No | EVA | |
| rs3389551481 | 289 | A>P | No | EVA | |
| rs3389544677 | 291 | M>V | No | EVA | |
| rs3389554982 | 317 | D>N | No | EVA | |
| rs3389552798 | 351 | K>* | No | EVA | |
| rs3389566942 | 353 | G>R | No | EVA | |
| rs3389459678 | 374 | Q>K | No | EVA | |
| rs3389518142 | 374 | Q>R | No | EVA | |
| rs3409332927 | 389 | T>S | No | EVA | |
| rs3413064415 | 390 | N>I | No | EVA | |
| rs3407474740 | 390 | N>Y | No | EVA | |
| rs3409332930 | 391 | E>V | No | EVA | |
| rs3389531312 | 401 | S>C | No | EVA | |
| rs3409460768 | 446 | R>W | No | EVA | |
| rs3389551416 | 447 | S>F | No | EVA | |
| rs3389546685 | 494 | F>Y | No | EVA | |
| rs3389566909 | 505 | L>R | No | EVA | |
| rs3409600992 | 528 | L>Q | No | EVA | |
| rs3389543911 | 545 | Q>P | No | EVA | |
| rs3389551478 | 547 | E>K | No | EVA | |
| rs3389546681 | 549 | L>I | No | EVA | |
| rs3389459646 | 553 | K>M | No | EVA |
No associated diseases with Q3U2S4
1 regional properties for Q3U2S4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | OTU domain | 213 - 336 | IPR003323 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.4.19.12 | Omega peptidases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| cysteine-type deubiquitinase activity | An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated. |
| deubiquitinase activity | An isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated. |
| Lys48-specific deubiquitinase activity | Hydrolysis of Lys48-linked ubiquitin unit(s) from a ubiquitinated protein. |
| Lys63-specific deubiquitinase activity | Hydrolysis of Lys63-Linked ubiquitin unit(s) from a ubiquitinated protein. |
14 GO annotations of biological process
| Name | Definition |
|---|---|
| CD8-positive, alpha-beta T cell differentiation | The process in which a relatively unspecialized T cell acquires specialized features of a mature CD8-positive, alpha-beta T cell. |
| negative regulation of canonical Wnt signaling pathway | Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. |
| negative regulation of interleukin-17 production | Any process that stops, prevents, or reduces the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines. |
| neural crest cell differentiation | The process in which a relatively unspecialized cell acquires specialized features of a neural crest cell. |
| positive regulation of TORC1 signaling | Any process that activates or increases the frequency, rate or extent of TORC1 signaling. |
| positive regulation of TORC2 signaling | Any process that activates or increases the frequency, rate or extent of TORC2 signaling. |
| proteasome-mediated ubiquitin-dependent protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. |
| protein deubiquitination | The removal of one or more ubiquitin groups from a protein. |
| protein K48-linked deubiquitination | A protein deubiquitination process in which a K48-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is removed from a protein. |
| protein K63-linked deubiquitination | A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is removed from a protein. |
| regulation of protein stability | Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation. |
| regulation of T-helper 17 type immune response | Any process that modulates the frequency, rate or extent of T-helper 17 type immune response. |
| response to lipopolysaccharide | Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. |
| T-helper 17 cell lineage commitment | The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 17 cell, a CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q96G74 | OTUD5 | OTU domain-containing protein 5 | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTILPKKKPP | PPDADPANEP | PPPGPLPPAP | RRGAGVGVGG | GGTGVGGGER | DRDSGVVGAR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PRASPPPQGP | LPGPPGALHR | WALAVPPGAV | AGPRPQQASP | PPCGGPGGPG | GGPGDALGAT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TAGVGAAGVV | VGVGGTVGVG | GCCSGPGHSK | RRRQAPGVGA | VGGASPEREE | VGAGYNSEDE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YEAAAARIEA | MDPATVEQQE | HWFEKALRDK | KGFIIKQMKE | DGACLFRAVA | DQVYGDQDMH |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EVVRKHCMDY | LMKNADYFSN | YVTEDFTTYI | NRKRKNNCHG | NHIEMQAMAE | MYNRPVEVYQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| YSTEPINTFH | GIHQNEDEPI | RVSYHRNIHY | NSVVNPNKAT | IGVGLGLPSF | KPGFAEQSLM |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KNAIKTSEES | WIEQQMLEDK | KRATDWEATN | EAIEEQVARE | SYLQWLRDQE | KQARQVRGPS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QPRKASATCS | SATAAASSGL | EEWTSRSPRQ | RSSASSPEHP | ELHAELGIKP | PSPGTVLALA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KPPSPCAPGT | SSQFSAGGDR | ATSPLVSLYP | ALECRALIQQ | MSPSAFGLND | WDDDEILASV |
| 550 | 560 | ||||
| LAVSQQEYLD | SMKKNKVHRE | PPPDKS |