Q3U128
Gene name |
Apcdd1 |
Protein name |
Protein APCDD1 |
Names |
Adenomatosis polyposis coli down-regulated 1 protein homolog |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:494504 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
4 structures for Q3U128
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 8E0P | X-ray | 233 A | A/B/C/D | 46-482 | PDB |
| 8E0R | X-ray | 195 A | A/B | 27-482 | PDB |
| 8E0W | X-ray | 215 A | A/B | 27-482 | PDB |
| AF-Q3U128-F1 | Predicted | AlphaFoldDB |
19 variants for Q3U128
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs264217544 | 35 | H>N | No | EVA | |
| rs3389506932 | 52 | C>S | No | EVA | |
| rs3408733764 | 80 | T>I | No | EVA | |
| rs3389454319 | 117 | N>K | No | EVA | |
| rs3389500787 | 171 | C>S | No | EVA | |
| rs3389473212 | 199 | T>I | No | EVA | |
| rs219265578 | 222 | S>N | No | EVA | |
| rs3389454337 | 285 | A>T | No | EVA | |
| rs3389500718 | 293 | G>R | No | EVA | |
| rs3408556396 | 323 | E>V | No | EVA | |
| rs3389515230 | 338 | T>I | No | EVA | |
| rs3389515188 | 373 | P>H | No | EVA | |
| rs3389519194 | 374 | M>L | No | EVA | |
| rs3389454310 | 384 | V>A | No | EVA | |
| rs3389454310 | 384 | V>G | No | EVA | |
| rs3389464591 | 426 | K>* | No | EVA | |
| rs3389454287 | 448 | S>I | No | EVA | |
| rs3389511649 | 476 | L>W | No | EVA | |
| rs265506794 | 514 | R>S | No | EVA |
No associated diseases with Q3U128
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| identical protein binding | Binding to an identical protein or proteins. |
| Wnt-protein binding | Binding to a Wnt-protein, a secreted growth factor involved in signaling. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| astrocyte cell migration | The orderly movement of an astrocyte, a class of large neuroglial (macroglial) cells in the central nervous system, the largest and most numerous neuroglial cells in the brain and spinal cord. |
| hair follicle development | The process whose specific outcome is the progression of the hair follicle over time, from its formation to the mature structure. A hair follicle is a tube-like opening in the epidermis where the hair shaft develops and into which the sebaceous glands open. |
| negative regulation of Wnt signaling pathway | Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway. |
| regulation of odontogenesis of dentin-containing tooth | Any process that modulates the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages which are borne on the jaws, or on other bones in the walls of the mouth or pharynx of most vertebrates. |
| Wnt signaling pathway | The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8J025 | APCDD1 | Protein APCDD1 | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSRVRRLLLG | YLFPALLLHG | LGEGSALLHP | DSRSHPRSLE | KSAWRAFKES | QCHHMLKHLH |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NGARITVQMP | PTIEGHWVST | GCEVRSGPEF | MTRSYRFYNN | NTFKAYQFYY | GSNRCTNPTY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TLIIRGKIRL | RQASWIIRGG | TEADYQLHGV | QVICHTEAVA | EQLSRLVNRT | CPGFLAPGGP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| WVQDVAYDLW | QEESNHECTK | AVNFAMHELQ | LIRVEKQYPH | HSLDHLVEEL | FLGDIHTDAT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QRVFYRPSSY | QPPLQNAKNH | NHACIACRII | FRSDEHHPPI | LPPKADLTIG | LHGEWVSQRC |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EVRPEVLFLT | RHFIFHDNNN | TWEGHYYHYS | DPVCKHPTFT | IYARGRYSRG | VLSSKVMGGT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EFVFKVNHMK | VTPMDAATAS | LLNVFSGNEC | GAEGSWQVGI | QQDVTHTNGC | VALGIKLPHT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| EYEIFKMEQD | TRGRYLLFNG | QRPSDGSSPD | RPEKRATSYQ | MPLVQCASSS | PRAEELLEDS |
| 490 | 500 | 510 | |||
| QGHLYGRAAG | RTAGSLLLPA | FVSLWTLPHW | RILR |