Q3TYX3

PR
Gene name
Smyd5 (Rai15)
Protein name
Histone-lysine N-trimethyltransferase SMYD5
Names
Protein NN8-4AG, Retinoic acid-induced protein 15, SET and MYND domain-containing protein 5, [histone H4]-lysine20 N-trimethyltransferase SMYD5
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:232187
EC number
2.1.1.372: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

355-416 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q3TYX3

Entry ID Method Resolution Chain Position Source
AF-Q3TYX3-F1 Predicted AlphaFoldDB

27 variants for Q3TYX3

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388842660 17 D>Y No EVA
rs3388847964 45 G>V No EVA
rs3388844513 68 R>M No EVA
rs3397013880 72 H>L No EVA
rs3396583619 77 L>V No EVA
rs3396838835 78 E>D No EVA
rs3396576373 81 E>V No EVA
rs3397167525 120 S>C* No EVA
rs3397059983 120 S>T No EVA
rs49923319 199 Q>E No EVA
rs49923319 199 Q>K No EVA
rs242168930 201 Q>H No EVA
rs45875302 202 A>E No EVA
rs240040012 214 D>G No EVA
rs3388807099 272 L>V No EVA
rs3388836343 304 S>T No EVA
rs3388838080 306 L>I No EVA
rs3388823046 323 T>N No EVA
rs3388847884 334 V>A No EVA
rs3388807118 340 I>T No EVA
rs3388834343 352 D>E No EVA
rs3388842707 358 R>C No EVA
rs3388841983 377 C>S No EVA
rs3388822940 395 E>G No EVA
rs3388836319 409 L>I No EVA
rs3388807094 412 E>G No EVA
rs3388836577 414 T>I No EVA

No associated diseases with Q3TYX3

9 regional properties for Q3TYX3

Type Name Position InterPro Accession
domain Zinc finger, TRAF-type 151 - 200 IPR001293-1
domain Zinc finger, TRAF-type 204 - 261 IPR001293-2
domain Zinc finger, RING-type 70 - 109 IPR001841
domain MATH/TRAF domain 358 - 507 IPR002083
conserved_site Zinc finger, RING-type, conserved site 85 - 94 IPR017907
domain TNF receptor-associated factor 6, C3HC3D-type RING zinc finger 67 - 124 IPR027139
domain TNF receptor-associated factor 6, MATH domain 359 - 508 IPR037309
domain TNF receptor-associated factor 6, zinc finger 2 157 - 183 IPR041310
domain TRAF1-6, MATH domain 381 - 504 IPR049342

Functions

Description
EC Number 2.1.1.372 Methyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
histone methyltransferase activity (H4-K20 specific) Catalysis of the reaction: S-adenosyl-L-methionine + histone H4 L-lysine (position 20) = S-adenosyl-L-homocysteine + histone H4 N6-methyl-L-lysine (position 20). This reaction is the addition of a methyl group onto lysine at position 20 of the histone H4 protein.
metal ion binding Binding to a metal ion.

5 GO annotations of biological process

Name Definition
histone H4-K20 trimethylation The modification of histone H4 by addition of three methyl groups to lysine at position 20 of the histone.
negative regulation of gene expression, epigenetic An epigenetic process that silences gene expression at specific genomic regions through chromatin remodelling either by modifying higher order chromatin fiber structure, nucleosomal histones, or the DNA.
negative regulation of transposition Any process that decreases the frequency, rate or extent of transposition. Transposition results in the movement of discrete segments of DNA between nonhomologous sites.
regulation of stem cell differentiation Any process that modulates the frequency, rate or extent of stem cell differentiation.
regulation of stem cell division Any process that modulates the frequency, rate or extent of stem cell division.

13 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q0P585 SMYD2 N-lysine methyltransferase SMYD2 Bos taurus (Bovine) SS
E1C5V0 SMYD2 N-lysine methyltransferase SMYD2 Gallus gallus (Chicken) SS
Q5ZIZ2 SMYD5 Histone-lysine N-trimethyltransferase SMYD5 Gallus gallus (Chicken) PR
Q9NRG4 SMYD2 N-lysine methyltransferase SMYD2 Homo sapiens (Human) SS
Q9H7B4 SMYD3 Histone-lysine N-methyltransferase SMYD3 Homo sapiens (Human) EV
Q6GMV2 SMYD5 Histone-lysine N-trimethyltransferase SMYD5 Homo sapiens (Human) PR
Q8R5A0 Smyd2 N-lysine methyltransferase SMYD2 Mus musculus (Mouse) EV
Q9CWR2 Smyd3 Histone-lysine N-methyltransferase SMYD3 Mus musculus (Mouse) SS
C3RZA1 SMYD2 N-lysine methyltransferase SMYD2 Sus scrofa (Pig) SS
Q7M6Z3 Smyd2 N-lysine methyltransferase SMYD2 Rattus norvegicus (Rat) SS
P34318 set-3 SET domain-containing protein 3 Caenorhabditis elegans PR
Q5RGL7 smyd2b N-lysine methyltransferase SMYD2-B Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q5BJI7 smyd2a N-lysine methyltransferase SMYD2-A Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MAASMCDVFS FCVGVADRAR GSVEVRYVDS IKGKGLFATQ LIRKGETIFI ERPLVAAQFL
70 80 90 100 110 120
WNALYQYRAC DHCLRALEKA EENAQRLTGK PSQILPHPEL CSVRKDLHQN CPHCQVMYCS
130 140 150 160 170 180
AECRLAAAEQ YHQILCPGPS HDPRHPLNKL QEAWRSVHYP PETASIMLMA RMVATVKQAK
190 200 210 220 230 240
DKDHWVRLFN HFCSRTANQE QAIVHKLLKG KFKDQLELLL GLFKEALYEE ALSLWFTPEG
250 260 270 280 290 300
FRSLFALVGT NGQGIGTSSL SQWVHACDAL ELTPQDREQL DTFIDQLYKD IEAATGEFLN
310 320 330 340 350 360
CEGSGLFVLQ SCCNHSCVPN AETSFPENNF VLHVTALEDI KPGEEICISY LDCCQRERSR
370 380 390 400 410
HSRHKILREN YLFNCSCPKC LAEADDPNVT SEEEEEEDEE EGEPEDAELG DEMTDV