Q3TYR5

PR
Gene name
Grxcr2 (Gm851)
Protein name
Glutaredoxin domain-containing cysteine-rich protein 2
Names
GRXCR1-like protein, Glutaredoxin domain-containing cysteine-rich protein 1-like protein
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:332309
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-106 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q3TYR5

Entry ID Method Resolution Chain Position Source
AF-Q3TYR5-F1 Predicted AlphaFoldDB

18 variants for Q3TYR5

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389508584 31 V>M No EVA
rs243394327 67 S>Y No EVA
rs224974123 74 Q>H No EVA
rs260632989 75 P>L No EVA
rs3408379119 77 S>F No EVA
rs3389479157 110 D>H No EVA
rs3389503831 121 K>T No EVA
rs3408476456 143 R>S No EVA
rs3408476421 144 K>N No EVA
rs3408476419 144 K>Q No EVA
rs3389512233 171 C>S No EVA
rs233902174 176 R>Q No EVA
rs244260256 180 P>L No EVA
rs3389512215 181 L>M No EVA
rs3389479180 188 F>V No EVA
rs250185681 199 V>I No EVA
rs3389500353 216 L>P No EVA
rs3389496070 247 Q>R No EVA

No associated diseases with Q3TYR5

No regional properties for Q3TYR5

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q3TYR5

Functions

Description
EC Number
Subcellular Localization
  • Cell projection, stereocilium
  • Concentrated at the basal taper region of stereocilia in early postnatal development (PubMed:30380417)
  • In adult hair cells, concentrated at the basal region but also detected along the stereocilium shaft (PubMed:30380417)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
microvillus Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells.
stereocilium base The tapered base of the stereocilium adjacent to where it joins the hair cell body. This region contains a rootlet comprised of bundled actin filaments which spans the joint and stabilizes the stereocilium.
stereocilium shaft The shaft comprises the majority of the length of the stereocilium. This region is notable for the extreme stability of actin filaments, which are highly crosslinked into a parallel bundle.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

4 GO annotations of biological process

Name Definition
auditory receptor cell stereocilium organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of auditory hair cells.
inner ear receptor cell stereocilium organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of inner ear receptor cells.
protein localization to organelle A process in which a protein is transported to, or maintained in, a location within an organelle.
sensory perception of sound The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEDSEKKLNQ KSDDKPRKVR FKISSSYSGR VLKQVFEDGQ ELESPKEEYP HSFLQEALEP
70 80 90 100 110 120
MDGVYGSGEV PKPQPYSPKL TAQRISVFRD SGAYTLAGSQ PLFNDYKAND HKPPPIIDFG
130 140 150 160 170 180
KIIIYTNNLK IIRTPMDKRD FMRKILQKED VAEEASLMIT GENDGDREQG CPLPERNGSP
190 200 210 220 230 240
LPESERTFLH SQHTQDGLVP EDCLHCQGSG IATCSLCHGS KFSMLANRFK ESYRALRCPA
250
CNENGLQPCR ICSP