Q3TVW5
PR
Gene name |
Tchp |
Protein name |
Trichoplein keratin filament-binding protein |
Names |
Protein TCHP, Mitochondrial protein with oncostatic activity, Mitostatin |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:77832 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q3TVW5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q3TVW5-F1 | Predicted | AlphaFoldDB |
25 variants for Q3TVW5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs864302252 | 74 | E>G | No | EVA | |
| rs3388777545 | 80 | E>D | No | EVA | |
| rs234627630 | 99 | A>S | No | EVA | |
| rs29566070 | 109 | G>S | No | EVA | |
| rs3396081636 | 125 | A>T | No | EVA | |
| rs3396022583 | 128 | E>A | No | EVA | |
| rs3388788755 | 146 | N>K | No | EVA | |
| rs228421502 | 161 | V>M | No | EVA | |
| rs3396193964 | 208 | R>G | No | EVA | |
| rs3396087951 | 209 | Q>L | No | EVA | |
| rs3388778708 | 268 | E>K | No | EVA | |
| rs3388777526 | 272 | F>Y | No | EVA | |
| rs3388767923 | 281 | L>P | No | EVA | |
| rs3388788769 | 297 | R>L | No | EVA | |
| rs257105741 | 335 | L>M | No | EVA | |
| rs3388778659 | 349 | L>Q | No | EVA | |
| rs32130715 | 387 | L>M | No | EVA | |
| rs239379463 | 388 | E>Q | No | EVA | |
| rs263250666 | 409 | R>K | No | EVA | |
| rs3388772156 | 410 | S>R | No | EVA | |
| rs3388783378 | 412 | E>V | No | EVA | |
| rs3388767928 | 442 | E>D | No | EVA | |
| rs232843911 | 476 | A>V | No | EVA | |
| rs3396002195 | 488 | L>V | No | EVA | |
| rs3388783694 | 498 | D>S | No | EVA |
No associated diseases with Q3TVW5
1 regional properties for Q3TVW5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Trichohyalin-plectin-homology domain | 143 - 480 | IPR043597 |
9 GO annotations of cellular component
| Name | Definition |
|---|---|
| apical cortex | The region that lies just beneath the plasma membrane on the apical edge of a cell. |
| centrosome | A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. |
| ciliary transition fiber | A nine-bladed, propeller-like protein complex that links the distal end of the basal body and the cilium to the plasma membrane. Functions in protein sorting and gating (i.e. active and passive transport of proteins in and out of the cilium). |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| desmosome | A cell-cell junction in which: on the cytoplasmic surface of each interacting plasma membrane is a dense plaque composed of a mixture of intracellular anchor proteins; a bundle of keratin intermediate filaments is attached to the surface of each plaque; transmembrane adhesion proteins of the cadherin family bind to the plaques and interact through their extracellular domains to hold the adjacent membranes together by a Ca2+-dependent mechanism. |
| keratin filament | A filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells. The keratins are the most diverse classes of IF proteins, with a large number of keratin isoforms being expressed. Each type of epithelium always expresses a characteristic combination of type I and type II keratins. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| apoptotic process | A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. |
| cell projection organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon. |
| negative regulation of cell growth | Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth. |
| negative regulation of cilium assembly | Any process that stops, prevents or reduces the frequency, rate or extent of cilium assembly. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9D439 | Cfap53 | Cilia- and flagella-associated protein 53 | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MALPTLPSYW | SSRKHMDLRQ | RQHQQEDQFR | QQWEQNSRYF | RTWDIHNSKQ | IEWSSKISYQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RSMHAYHCEK | MKEEKRKILE | LRRERLRELL | LEEQDLLAAE | LDELRLSMGL | REQRLREQHQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DLKSAREEQR | KLIAERLLYE | HWKKNNPKLR | ELELDLHKKH | VINSWATQKE | EKKQQEATEK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QENKRLENQY | AAARREAEAR | MRVEEERRQL | EGRLQAEALR | QQMEELKQKE | MEATKLKKEQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ENLLRQRWEL | ERLEEERRQM | AALRRKTELG | RFLKHQYNAQ | LNRRTQEIQE | ELEVDGRILQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ALLEKEGELQ | QVELARREQA | RADAAWMKQV | IEEQLQLEKA | REAELQQLLR | EEAKEMWEKR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EAEWAREQVA | RDRLMSEVLT | GRQQQILEKI | EQNRRAQEET | LKHREKLIRS | LEEGKQLAQR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| AKEESEELKL | ARKQELEAQV | AERQGQEWEA | ARQEEEEEEE | ARQAEEHSNA | LLQQEAKTMA |
| 490 | |||||
| EKGYQPKLHG | HLRIAWD |