Q3TVP5

PR
Gene name
Otulinl
Protein name
Inactive ubiquitin thioesterase OTULINL
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:223433
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-52 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q3TVP5

Entry ID Method Resolution Chain Position Source
AF-Q3TVP5-F1 Predicted AlphaFoldDB

24 variants for Q3TVP5

Variant ID(s) Position Change Description Diseaes Association Provenance
rs46982994 29 V>L No EVA
rs45789070 49 L>I No EVA
rs237266351 51 P>L No EVA
rs47892510 56 F>L No EVA
rs3389367031 61 S>N No EVA
rs3389358424 74 I>F No EVA
rs3389370839 81 F>Y No EVA
rs3389370910 87 V>M No EVA
rs265119964 106 P>Q No EVA
rs221101140 110 L>Q No EVA
rs3405891553 143 F>* No EVA
rs3389317138 178 Q>K No EVA
rs3389357174 204 K>N No EVA
rs3389325854 213 M>V No EVA
rs261387009 221 S>N No EVA
rs223578338 230 A>T No EVA
rs3389345097 248 V>I No EVA
rs213313088 251 A>V No EVA
rs3389360376 282 M>I No EVA
rs3389358450 292 C>S No EVA
rs46030586 293 G>D No EVA
rs3389353348 294 L>F No EVA
rs3389336836 295 D>V No EVA
rs3405639073 297 I>L No EVA

No associated diseases with Q3TVP5

No regional properties for Q3TVP5

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q3TVP5

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Endoplasmic reticulum membrane ; Peripheral membrane protein
  • Nucleus envelope
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
extrinsic component of endoplasmic reticulum membrane The component of the endoplasmic reticulum membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
nuclear envelope The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

No GO annotations of biological process

Name Definition
No GO annotations for biological process

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9NUU6 OTULINL Inactive ubiquitin thioesterase OTULINL Homo sapiens (Human) PR
Q96BN8 OTULIN Ubiquitin thioesterase otulin Homo sapiens (Human) PR
Q3B7D8 Otulinl Inactive ubiquitin thioesterase OTULINL Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MEAPRSAPRE RERARTTSGS DQVHSWILVT SQVLSAAWRI ARAFVMTTLS PLSATFSYFR
70 80 90 100 110 120
SLYLYLGHQL KWWIGYLQRK FKRNLSVEAE VDLLSYCARE WKGEAPRARL MRKAYEELFW
130 140 150 160 170 180
RHHIKCVRAV KRDNYDALRS VLFQIFSQGL SFPSWMKEKD IVKLPEKLLF SQGCNWIQQY
190 200 210 220 230 240
SFGPEKYTGS NVFGKLRKCV ELLKLQWTEF SGMRDHHKRG SMCNSLFSDA ILECKLYEAL
250 260 270 280 290 300
KFLMLYQVTE AYEQMKTNKV IPSLFRLLFS RESSPDPLSF MMNHLNSIGD TCGLDQIDMF
310 320 330 340 350
ILGYSLQVKI KVFRLFKFNS RDFAVCYPEE PLREWPEISL LTENGHHYHI PVF