Q3TL26
Gene name |
Tfb2m |
Protein name |
Dimethyladenosine transferase 2, mitochondrial |
Names |
Mitochondrial 12S rRNA dimethylase 2, Mitochondrial transcription factor B2, mTFB2M, mtTFB2, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:15278 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q3TL26
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q3TL26-F1 | Predicted | AlphaFoldDB |
17 variants for Q3TL26
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs255789403 | 12 | I>L | No | EVA | |
| rs32633261 | 12 | I>M | No | EVA | |
| rs217670780 | 16 | A>T | No | EVA | |
| rs241765487 | 48 | I>M | No | EVA | |
| rs224868168 | 49 | E>Q | No | EVA | |
| rs3388521236 | 71 | T>K | No | EVA | |
| rs3388521236 | 71 | T>R | No | EVA | |
| rs3388518726 | 92 | N>T | No | EVA | |
| rs3388517040 | 94 | S>P | No | EVA | |
| rs3388521266 | 121 | A>T | No | EVA | |
| rs3388516152 | 213 | E>K | No | EVA | |
| rs222784870 | 248 | M>L | No | EVA | |
| rs3388520963 | 251 | L>F | No | EVA | |
| rs252850932 | 271 | V>M | No | EVA | |
| rs32636717 | 273 | T>M | No | EVA | |
| rs3388521271 | 304 | T>I | No | EVA | |
| rs584053608 | 394 | M>V | No | EVA |
No associated diseases with Q3TL26
1 regional properties for Q3TL26
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Ribosomal RNA adenine methylase transferase, N-terminal | 83 - 282 | IPR020598 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| mitochondrial matrix | The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. |
| mitochondrial nucleoid | The region of a mitochondrion to which the DNA is confined. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| mitochondrial transcription factor activity | Interacting with the mitochondrial promoter DNA to modulate transcription by the mitochondrial RNA polymerase. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| rRNA (adenine-N6,N6-)-dimethyltransferase activity | Catalysis of the dimethylation of two adjacent adenine residues in a rRNA, using S-adenosyl-L-methionine as a methyl donor. |
| transcription coregulator activity | A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| mitochondrial transcription | The synthesis of RNA from a mitochondrial DNA template, usually by a specific mitochondrial RNA polymerase. |
| regulation of DNA-templated transcription | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
| rRNA methylation | The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule. |
| transcription initiation at mitochondrial promoter | A transcription initiation process that takes place at a promoter on the mitochondrial chromosome. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRGPAMRLPP | RIALSALARG | PSCILGSGAA | TRKDWQTRNR | RGFSDFNIEP | LPDSDLEESS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PWTSRNRSEP | TRHIACKKAA | RNLVRDLLEH | QNPSRQIILE | CNPGPGILTG | ALLKAGARVV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AFESEKTFIP | HLEPLQRNMD | GELQVVHCDF | FKMDPRYQEV | VRPDVSSQAI | FQNLGIKAVP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| WSAGVPIKVF | GILPYKHERR | ILWKILFDLY | SCESIYRYGR | VELNMFVSEK | EFRKLIATPK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RPDLYQVMAV | LWQVACDVKF | LHMEPWSSFS | VHTENGHLEK | SKHGESVNLL | KQNLYLVRMT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PRRTLFTENL | SPLNYDIFFH | LVKHCFGKRN | APIIRHLRSL | STVDPINILR | QIRKNPGDTA |
| 370 | 380 | 390 | |||
| ARMYPHDFKK | LFETIEQSED | SVFKWIYDYC | PEDMEF |