Q3T904
PR
Gene name |
ATG9A |
Protein name |
Autophagy-related protein 9A |
Names |
APG9-like 1, Autophagy protein 9 |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:540482 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q3T904
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q3T904-F1 | Predicted | AlphaFoldDB |
179 variants for Q3T904
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs446338105 | 6 | T>S | No | EVA | |
| rs442251817 | 38 | H>Y | No | EVA | |
| rs382994847 | 40 | I>V | No | EVA | |
| rs445230379 | 190 | T>P | No | EVA | |
| rs482229368 | 197 | C>Y | No | EVA | |
| rs521892108 | 211 | R>L | No | EVA | |
| rs483054007 | 224 | N>Y | No | EVA | |
| rs463042214 | 225 | K>Q | No | EVA | |
| rs449391274 | 227 | L>F | No | EVA | |
| rs480488269 | 228 | L>V | No | EVA | |
| rs440518366 | 229 | P>T | No | EVA | |
| rs438411040 | 240 | V>G | No | EVA | |
| rs476269293 | 249 | Y>D | No | EVA | |
| rs436083305 | 269 | L>R | No | EVA | |
| rs453969549 | 273 | Y>H | No | EVA | |
| rs433750143 | 275 | R>G | No | EVA | |
| rs469419899 | 277 | G>A | No | EVA | |
| rs437860654 | 277 | G>R | No | EVA | |
| rs469419899 | 277 | G>V | No | EVA | |
| rs480525081 | 279 | R>W | No | EVA | |
| rs462087253 | 281 | E>G | No | EVA | |
| rs447043588 | 294 | G>V | No | EVA | |
| rs442329230 | 298 | F>L | No | EVA | |
| rs478194310 | 304 | I>L | No | EVA | |
| rs482537913 | 311 | Y>* | No | EVA | |
| rs444743727 | 311 | Y>C | No | EVA | |
| rs462551542 | 313 | F>L | No | EVA | |
| rs442438911 | 319 | V>G | No | EVA | |
| rs473931161 | 320 | L>F | No | EVA | |
| rs440263608 | 321 | K>R | No | EVA | |
| rs471632939 | 322 | R>G | No | EVA | |
| rs451361224 | 324 | P>L | No | EVA | |
| rs437903114 | 326 | A>P | No | EVA | |
| rs469207688 | 327 | L>M | No | EVA | |
| rs435546664 | 329 | A>G | No | EVA | |
| rs466938432 | 332 | W>G | No | EVA | |
| rs446921156 | 333 | S>P | No | EVA | |
| rs478317406 | 336 | G>A | No | EVA | |
| rs464772993 | 338 | C>S | No | EVA | |
| rs450946296 | 339 | Y>H | No | EVA | |
| rs450946296 | 339 | Y>N | No | EVA | |
| rs482616860 | 339 | Y>S | No | EVA | |
| rs442475797 | 340 | L>P | No | EVA | |
| rs480187229 | 341 | R>P | No | EVA | |
| rs460108480 | 342 | H>D | No | EVA | |
| rs440151072 | 342 | H>P | No | EVA | |
| rs471434900 | 343 | F>L | No | EVA | |
| rs451487239 | 345 | E>D | No | EVA | |
| rs475792616 | 346 | L>R | No | EVA | |
| rs444188868 | 346 | L>V | No | EVA | |
| rs455459178 | 347 | E>* | No | EVA | |
| rs435583604 | 347 | E>D | No | EVA | |
| rs466818043 | 348 | H>P | No | EVA | |
| rs453146868 | 348 | H>Q | No | EVA | |
| rs433271941 | 350 | L>P | No | EVA | |
| rs451116044 | 351 | Q>H | No | EVA | |
| rs464620094 | 351 | Q>P | No | EVA | |
| rs464620094 | 351 | Q>R | No | EVA | |
| rs482462190 | 352 | S>P | No | EVA | |
| rs468895445 | 355 | N>T | No | EVA | |
| rs448819938 | 358 | Y>* | No | EVA | |
| rs480078896 | 395 | T>P | No | EVA | |
| rs136147179 | 404 | V>G | No | EVA | |
| rs446361711 | 425 | I>S | No | EVA | |
| rs477993293 | 432 | F>V | No | EVA | |
| rs473061257 | 498 | A>S | No | EVA | |
| rs460036534 | 537 | G>S | No | EVA | |
| rs477301548 | 542 | A>D | No | EVA | |
| rs439500506 | 542 | A>T | No | EVA | |
| rs463724496 | 547 | Q>K | No | EVA | |
| rs443646865 | 554 | E>A | No | EVA | |
| rs475142666 | 557 | L>I | No | EVA | |
| rs455013594 | 557 | L>P | No | EVA | |
| rs441468769 | 558 | M>L | No | EVA | |
| rs472811435 | 564 | N>Y | No | EVA | |
| rs432678948 | 569 | P>R | No | EVA | |
| rs470960909 | 588 | G>R | No | EVA | |
| rs465878508 | 618 | L>R | No | EVA | |
| rs801292445 | 619 | S>G | No | EVA | |
| rs470098286 | 625 | V>G | No | EVA | |
| rs435157158 | 627 | G>S | No | EVA | |
| rs447679635 | 628 | S>T | No | EVA | |
| rs479190560 | 632 | G>A | No | EVA | |
| rs876196171 | 638 | D>V | No | EVA | |
| rs439011614 | 639 | L>P | No | EVA | |
| rs459032250 | 639 | L>V | No | EVA | |
| rs462949275 | 645 | R>S | No | EVA | |
| rs443090718 | 646 | A>V | No | EVA | |
| rs474259500 | 647 | E>A | No | EVA | |
| rs454426992 | 648 | V>A | No | EVA | |
| rs472318507 | 650 | S>T | No | EVA | |
| rs432034739 | 652 | L>M | No | EVA | |
| rs470016075 | 653 | R>G | No | EVA | |
| rs449865176 | 654 | S>P | No | EVA | |
| rs447716749 | 656 | S>L | No | EVA | |
| rs467658112 | 656 | S>P | No | EVA | |
| rs467658112 | 656 | S>T | No | EVA | |
| rs458850930 | 657 | P>S | No | EVA | |
| rs445340038 | 658 | L>R | No | EVA | |
| rs876179262 | 659 | Q>H | No | EVA | |
| rs876325516 | 659 | Q>R | No | EVA | |
| rs876440832 | 660 | P>H | No | EVA | |
| rs876440832 | 660 | P>R | No | EVA | |
| rs483150952 | 660 | P>S | No | EVA | |
| rs462987887 | 661 | G>C | No | EVA | |
| rs442976823 | 665 | T>A | No | EVA | |
| rs442976823 | 665 | T>P | No | EVA | |
| rs460669303 | 673 | T>I | No | EVA | |
| rs440824281 | 675 | S>C | No | EVA | |
| rs440824281 | 675 | S>Y | No | EVA | |
| rs136794153 | 677 | V>A | No | EVA | |
| rs136794153 | 677 | V>G | No | EVA | |
| rs483200996 | 678 | D>G | No | EVA | |
| rs469303166 | 679 | A>T | No | EVA | |
| rs449430711 | 680 | R>K | No | EVA | |
| rs876448621 | 681 | T>A | No | EVA | |
| rs480602696 | 687 | S>R | No | EVA | |
| rs460554765 | 688 | V>G | No | EVA | |
| rs440704985 | 689 | W>G | No | EVA | |
| rs458554728 | 693 | L>R | No | EVA | |
| rs438372121 | 702 | A>S | No | EVA | |
| rs482290899 | 723 | A>V | No | EVA | |
| rs133538165 | 730 | W>G | No | EVA | |
| rs133538165 | 730 | W>R | No | EVA | |
| rs453356784 | 733 | R>L | No | EVA | |
| rs453356784 | 733 | R>P | No | EVA | |
| rs433233581 | 734 | E>V | No | EVA | |
| rs464734332 | 735 | S>N | No | EVA | |
| rs451067985 | 735 | S>R | No | EVA | |
| rs437535943 | 737 | E>D | No | EVA | |
| rs468858731 | 738 | S>R | No | EVA | |
| rs448934312 | 740 | E>V | No | EVA | |
| rs460126432 | 741 | S>G | No | EVA | |
| rs446524783 | 741 | S>N | No | EVA | |
| rs457782760 | 745 | E>K | No | EVA | |
| rs462234201 | 751 | R>W | No | EVA | |
| rs481965634 | 753 | T>P | No | EVA | |
| rs461855246 | 762 | Y>S | No | EVA | |
| rs441837298 | 765 | A>V | No | EVA | |
| rs473403254 | 769 | P>T | No | EVA | |
| rs453240542 | 775 | T>A | No | EVA | |
| rs457568567 | 776 | A>D | No | EVA | |
| rs471100500 | 776 | A>S | No | EVA | |
| rs455251761 | 781 | F>I | No | EVA | |
| rs466538274 | 785 | Y>C | No | EVA | |
| rs446382922 | 787 | G>R | No | EVA | |
| rs463719455 | 790 | D>E | No | EVA | |
| rs443753760 | 793 | T>P | No | EVA | |
| rs475054441 | 794 | V>G | No | EVA | |
| rs461558717 | 795 | P>A | No | EVA | |
| rs441394255 | 798 | P>S | No | EVA | |
| rs472910707 | 800 | H>L | No | EVA | |
| rs452755993 | 801 | F>L | No | EVA | |
| rs432643179 | 802 | S>T | No | EVA | |
| rs456723917 | 804 | L>V | No | EVA | |
| rs436903705 | 805 | P>H | No | EVA | |
| rs448218572 | 809 | W>L | No | EVA | |
| rs434557825 | 812 | D>H | No | EVA | |
| rs445943480 | 817 | S>A | No | EVA | |
| rs477260260 | 817 | S>L | No | EVA | |
| rs445943480 | 817 | S>T | No | EVA | |
| rs450102542 | 821 | E>D | No | EVA | |
| rs463756422 | 821 | E>G | No | EVA | |
| rs481557807 | 823 | V>G | No | EVA | |
| rs441422055 | 826 | E>A | No | EVA | |
| rs459039064 | 827 | G>A | No | EVA | |
| rs472860101 | 827 | G>R | No | EVA | |
| rs459039064 | 827 | G>V | No | EVA | |
| rs439062423 | 828 | S>* | No | EVA | |
| rs476702423 | 829 | E>G | No | EVA | |
| rs456813869 | 830 | D>N | No | EVA | |
| rs436742501 | 831 | E>A | No | EVA | |
| rs474535982 | 831 | E>D | No | EVA | |
| rs454632679 | 832 | L>P | No | EVA | |
| rs454632679 | 832 | L>R | No | EVA | |
| rs445746315 | 835 | Q>L | No | EVA | |
| rs445746315 | 835 | Q>P | No | EVA | |
| rs467793717 | 840 | V>W | No | EVA | |
| rs447583490 | 840 | V>Y | No | EVA |
No associated diseases with Q3T904
No regional properties for Q3T904
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q3T904 | |||
Functions
13 GO annotations of cellular component
| Name | Definition |
|---|---|
| autophagosome | A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the lytic vacuole/lysosome for degradation as part of macroautophagy. |
| autophagosome membrane | The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered. |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| late endosome membrane | The lipid bilayer surrounding a late endosome. |
| mitochondrial membrane | Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| phagophore assembly site | Punctate structures proximal to the endoplasmic reticulum which are the sites where the Atg machinery assembles upon autophagy induction. |
| phagophore assembly site membrane | A cellular membrane associated with the phagophore assembly site. |
| recycling endosome membrane | The lipid bilayer surrounding a recycling endosome. |
| trans-Golgi network | The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| phospholipid scramblase activity | Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, by an ATP-independent mechanism. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| autophagosome assembly | The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm. |
| autophagy of mitochondrion | The autophagic process in which mitochondria are delivered to a type of vacuole and degraded in response to changing cellular conditions. |
| bone morphogenesis | The process in which bones are generated and organized. |
| late nucleophagy | A type of nucleophagy, distinct from piecemeal microautophagy of the nucleus (PNM) where the nuclear material is delivered to the vacuole/lysosome for breakdown and recycling later than observed for PNM. |
| positive regulation of necrotic cell death | Any process that increases the rate, frequency or extent of necrotic cell death. Necrotic cell death is a cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents. |
| protein localization to phagophore assembly site | Any process in which a protein is transported to, or maintained at, the phagophore assembly site (PAS). |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q7Z3C6 | ATG9A | Autophagy-related protein 9A | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAQFDTEYQR | LEASYSDSPP | GEEDLLVHVP | EGSKSPWHHI | ENLDLFFSRV | YNLHQKNGFT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| CMLIGEIFEL | MQFLFVVAFT | TFLVSCVDYD | ILFANKMVNH | SLHPTEPVKV | TLPDAFLPAQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VCSARIQENG | SLITILVIAG | VFWVHRLIKF | IYNICCYWEI | HSFYLHALRI | PMSALPYCTW |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QEVQARIVQT | QKEHQICIHK | RELTELDIYH | RILRFQNYMV | ALVNKSLLPL | RFRLPGLGEV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VFFTRGLKYN | FELILFWGPG | SLFLNEWSLK | AEYKRGGQRL | ELAQRLSNRI | LWIGIANFLL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| CPLILIWQIL | YAFFSYAEVL | KREPGALGAR | CWSLYGRCYL | RHFNELEHEL | QSRLNRGYKP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ASKYMNCFLS | PLLTLLAKNC | AFFAGSILAV | LIALTIYDED | VLAVEHVLTT | VTLLGVTVTV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| CRSFIPDQHM | VFCPEQLLRV | ILAHIHYMPD | HWQGNAHRSQ | TRDEFAQLFQ | YKAVFILEEL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LSPIVTPLIL | IFCLRPRALE | IIDFFRNFTV | EVVGVGDTCS | FAQMDVRQHG | HPQWLSGGQT |
| 550 | 560 | 570 | 580 | 590 | 600 |
| EASVYQQAED | GKTELSLMHF | AITNPGWQPP | RESTAFLGFL | KEQVQRDGAA | AGLAQGGLLP |
| 610 | 620 | 630 | 640 | 650 | 660 |
| ENALFTSIQS | LQSESEPLSL | IANVVAGSSC | RGPPLPRDLQ | GSRHRAEVAS | ALRSFSPLQP |
| 670 | 680 | 690 | 700 | 710 | 720 |
| GQAPTGRAPS | TMTGSGVDAR | TASSGSSVWE | GQLQSLVLSE | YASTEMSLHA | LYMHQLHKQQ |
| 730 | 740 | 750 | 760 | 770 | 780 |
| AQAEPERHVW | HRRESDESGE | SAPEEGGEGA | RATQPIPRSA | SYPCAAPRPG | APETTALQGG |
| 790 | 800 | 810 | 820 | 830 | |
| FQRRYGGITD | PGTVPRAPSH | FSRLPLGGWA | EDGQSASRHP | EPVPEEGSED | ELPPQVHKV |