Q3T0T8

PR
Gene name
RGS5
Protein name
Regulator of G-protein signaling 5
Names
RGS5
Species
Bos taurus (Bovine)
KEGG Pathway
bta:540509
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

3-90 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q3T0T8

Entry ID Method Resolution Chain Position Source
AF-Q3T0T8-F1 Predicted AlphaFoldDB

23 variants for Q3T0T8

Variant ID(s) Position Change Description Diseaes Association Provenance
rs469923173 40 Y>* No EVA
rs445364996 54 S>* No EVA
rs466941108 57 E>D No EVA
rs434016297 58 A>S No EVA
rs455610035 60 Q>R No EVA
rs456143806 66 D>A No EVA
rs437881600 66 D>Y No EVA
rs876353547 67 K>Q No EVA
rs471420952 67 K>R No EVA
rs472220740 70 Q>E No EVA
rs442427854 71 N>T No EVA
rs462428722 73 Y>H No EVA
rs470151159 82 L>P No EVA
rs435667294 85 E>* No EVA
rs441312697 100 Y>H No EVA
rs455645305 108 K>E No EVA
rs453244666 112 T>I No EVA
rs441940131 113 A>S No EVA
rs463695233 123 V>E No EVA
rs482002810 126 P>T No EVA
rs444758529 141 K>* No EVA
rs453511510 145 E>* No EVA
rs438830989 155 Q>H No EVA

No associated diseases with Q3T0T8

2 regional properties for Q3T0T8

Type Name Position InterPro Accession
domain RGS domain 61 - 180 IPR016137
domain Regulator of G-protein signalling 5, RGS domain 65 - 178 IPR034956

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

1 GO annotations of biological process

Name Definition
negative regulation of signal transduction Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O46471 RGS16 Regulator of G-protein signaling 16 Bos taurus (Bovine) PR
P49802 RGS7 Regulator of G-protein signaling 7 Homo sapiens (Human) PR
O15539 RGS5 Regulator of G-protein signaling 5 Homo sapiens (Human) PR
Q9Z2H1 Rgs11 Regulator of G-protein signaling 11 Mus musculus (Mouse) PR
O54829 Rgs7 Regulator of G-protein signaling 7 Mus musculus (Mouse) PR
Q0QWG9 Grid2ip Delphilin Mus musculus (Mouse) PR
Q18312 rgs-3 Regulator of G-protein signaling rgs-3 Caenorhabditis elegans PR
Q8H1F2 RGS1 Regulator of G-protein signaling 1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MCKGLAALPH SCLERAKEIK IKLGILLQKP ESAIDLVIPY NEKPEKPAKT QKPSLDEALQ
70 80 90 100 110 120
WRDSLDKLLQ NNYGLASFKS FLKSEFSEEN LEFWMACEDY KKIKSPVKMA ETAKKIYEEF
130 140 150 160 170 180
IQVEAPKEVN IDHFTKEITV KNLVEPSPSS FDVAQKRIHA LMEKDSLPRF VRSEFYQEFI
K