AiPD: Autoinhibited Protein Database

Gene name	TINAG
Protein name	Tubulointerstitial nephritis antigen
Names	TIN-Ag
Species	Bos taurus (Bovine)
KEGG Pathway	bta:512517
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

80-159 (Predicted disordered autoinhibitory region) PR

80-159 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q3SZI1-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs450501417	2	C>W	No	EVA
rs524565610	31	P>S	No	EVA
rs464938730	69	G>D	No	EVA
rs208672481	71	V>M	No	EVA
rs525050548	111	R>G	No	EVA
rs717471967	115	W>L	No	EVA
rs481133869	168	D>A	No	EVA
rs475415747	181	G>*	No	EVA
rs210709686	212	T>P	No	EVA
rs440789720	219	E>*	No	EVA
rs437034850	300	G>*	No	EVA
rs456314722	373	P>T	No	EVA
rs721181727	406	R>Q	No	EVA
rs719997286	426	G>R	No	EVA
rs715535790	427	Q>K	No	EVA
rs459700011	433	I>F	No	EVA
rs441241865	434	A>S	No	EVA
rs480676589	434	A>V	No	EVA
rs443552550	437	S>F	No	EVA
rs443552550	437	S>Y	No	EVA
rs476510846	438	W>G	No	EVA
rs439435863	440	K>N	No	EVA
rs451571993	440	K>R	No	EVA
rs472350586	441	S>A	No	EVA
rs472350586	441	S>P	No	EVA
rs472350586	441	S>T	No	EVA
rs453847630	441	S>Y	No	EVA
rs468235354	442	W>G	No	EVA
rs470320447	445	N>K	No	EVA
rs445471661	446	G>V	No	EVA
rs466178527	447	Y>F	No	EVA
rs447787315	450	I>F	No	EVA
rs480763227	450	I>N	No	EVA
rs447787315	450	I>V	No	EVA
rs462199405	451	L>F	No	EVA
rs458047073	454	V>G	No	EVA
rs439499246	461	K>*	No	EVA

Type	Name	Position	InterPro Accession
conserved_site	Argininosuccinate synthase, conserved site	10 - 18	IPR018223-1
conserved_site	Argininosuccinate synthase, conserved site	117 - 128	IPR018223-2

		Description
EC Number
Subcellular Localization	Secreted, extracellular space, extracellular matrix, basement membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
basement membrane	A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.
extracellular space	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
lysosome	A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.

Name	Definition
cysteine-type peptidase activity	Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.

Name	Definition
cell adhesion	The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
proteolysis	The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9UJW2	TINAG	Tubulointerstitial nephritis antigen	Homo sapiens (Human)	PR