Q3SZ27
Gene name |
APOL (FAM121A, MIC27) |
Protein name |
MICOS complex subunit MIC27 |
Names |
Apolipoprotein O-like, Protein FAM121A |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:506138 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q3SZ27
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q3SZ27-F1 | Predicted | AlphaFoldDB |
33 variants for Q3SZ27
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs482977116 | 9 | L>V | No | EVA | |
| rs458063259 | 15 | G>C | No | EVA | |
| rs439556770 | 17 | I>R | No | EVA | |
| rs460341028 | 36 | V>G | No | EVA | |
| rs472350160 | 36 | V>M | No | EVA | |
| rs455701187 | 41 | L>I | No | EVA | |
| rs436283100 | 44 | Y>S | No | EVA | |
| rs469289491 | 45 | T>A | No | EVA | |
| rs450578671 | 45 | T>N | No | EVA | |
| rs450578671 | 45 | T>S | No | EVA | |
| rs432124800 | 46 | A>G | No | EVA | |
| rs446462463 | 48 | P>R | No | EVA | |
| rs440701510 | 99 | D>E | No | EVA | |
| rs473579870 | 103 | Y>C | No | EVA | |
| rs436481190 | 111 | F>L | No | EVA | |
| rs457302964 | 120 | V>I | No | EVA | |
| rs3423620283 | 126 | F>L | No | EVA | |
| rs432321268 | 127 | I>L | No | EVA | |
| rs465383269 | 128 | S>L | No | EVA | |
| rs445923501 | 129 | A>E | No | EVA | |
| rs450639874 | 133 | S>C | No | EVA | |
| rs432035498 | 140 | Y>S | No | EVA | |
| rs465051080 | 148 | G>E | No | EVA | |
| rs479417373 | 154 | P>R | No | EVA | |
| rs460961897 | 158 | V>A | No | EVA | |
| rs449455393 | 159 | I>L | No | EVA | |
| rs452891313 | 198 | K>E | No | EVA | |
| rs797873248 | 202 | A>T | No | EVA | |
| rs476433668 | 209 | A>V | No | EVA | |
| rs449113152 | 246 | L>F | No | EVA | |
| rs438686288 | 248 | D>G | No | EVA | |
| rs471751596 | 254 | P>A | No | EVA | |
| rs441020225 | 263 | R>K | No | EVA |
No associated diseases with Q3SZ27
1 regional properties for Q3SZ27
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Alpha-ketoglutarate-dependent dioxygenase AlkB-like | 120 - 241 | IPR027450 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| MICOS complex | Mitochondrial inner membrane complex involved in maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. In Saccharomyces cerevisiae the complex has six subunits: MIC10, MIC12, MIC19, MIC26, MIC27, and MIC60. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| cristae formation | The assembly of cristae, the inwards folds of the inner mitochondrial membrane. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAALRMGKLT | TMPTGLIYAS | ISVHVAKEEE | SKKQLVKPEQ | LPIYTAPPLQ | SKYVEEQPGH |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LQMGFASIRT | TTSRYIGWCK | GVYVFVKNGI | MDTVQFGKDA | YVYLKNPPRD | FLPKIGVITV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SGLAGFISAR | KGSRFKRIAY | PLGLATLGAT | VCYPVQSVII | AKVAGKKAYA | TSQQMYEAVK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SLWTKNNKKL | PEHKEKTKLG | SADETETPAE | TTHNLKHSVP | LPAELSSETK | TKSTSGATQF |
| 250 | 260 | ||||
| MPDPKLMDHG | QSHPEDIDMY | STRS |