Q3SWZ7

PR
Gene name
WRAP53
Protein name
Telomerase Cajal body protein 1
Names
WD repeat-containing protein 79, WD40 repeat-containing protein antisense to TP53 gene homolog
Species
Bos taurus (Bovine)
KEGG Pathway
bta:509631
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-76 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q3SWZ7

Entry ID Method Resolution Chain Position Source
AF-Q3SWZ7-F1 Predicted AlphaFoldDB

No variants for Q3SWZ7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q3SWZ7

No associated diseases with Q3SWZ7

6 regional properties for Q3SWZ7

Type Name Position InterPro Accession
repeat WD40 repeat 149 - 188 IPR001680-1
repeat WD40 repeat 252 - 295 IPR001680-2
repeat WD40 repeat 302 - 344 IPR001680-3
repeat WD40 repeat 347 - 387 IPR001680-4
repeat WD40 repeat 392 - 432 IPR001680-5
repeat WD40 repeat 441 - 477 IPR001680-6

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, Cajal body
  • Chromosome, telomere
  • Chromosome
  • Released from telomerase RNA template component (TERC) in mitotic cells coincident with delocalization from Cajal bodies
  • In response to DNA damage, localizes to sites of DNA double-strand breaks following phosphorylation by ATM
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
Cajal body A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA.
chromosome, telomeric region The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres).
site of double-strand break A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.
telomerase holoenzyme complex Telomerase is a ribonucleoprotein enzyme complex, with a minimal catalytic core composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition. In vivo, the holoenzyme complex often contains additional subunits.

2 GO annotations of molecular function

Name Definition
RNA binding Binding to an RNA molecule or a portion thereof.
telomerase RNA binding Binding to the telomerase RNA template.

12 GO annotations of biological process

Name Definition
Cajal body organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of Cajal bodies, nuclear bodies that appear ultrastructurally as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter and are enriched in ribonucleoproteins, and certain general RNA polymerase II transcription factors.
DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
positive regulation of DNA repair Any process that activates or increases the frequency, rate or extent of DNA repair.
positive regulation of double-strand break repair Any process that activates or increases the frequency, rate or extent of double-strand break repair.
positive regulation of double-strand break repair via homologous recombination Any process that activates or increases the frequency, rate or extent of double-strand break repair via homologous recombination.
positive regulation of double-strand break repair via nonhomologous end joining Any process that activates or increases the frequency, rate or extent of double-strand break repair via nonhomologous end joining.
positive regulation of telomerase activity Any process that activates or increases the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
protein localization to Cajal body A process in which a protein is transported to, or maintained in, a location within a Cajal body.
RNA folding The process of assisting in the covalent and noncovalent assembly of single or multimeric RNAs into the correct tertiary structure.
scaRNA localization to Cajal body A process in which a small Cajal body-specific RNA is transported to, or maintained in, a Cajal body.
telomere formation via telomerase A cellular process that results in the formation of a telomere at a non-telomeric double-stranded DNA end that involves the activity of a telomerase enzyme.
telomere maintenance via telomerase The maintenance of proper telomeric length by the addition of telomeric repeats by telomerase.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9BUR4 WRAP53 Telomerase Cajal body protein 1 Homo sapiens (Human) PR
Q8VC51 Wrap53 Telomerase Cajal body protein 1 Mus musculus (Mouse) PR
Q5XII5 Wrap53 Telomerase Cajal body protein 1 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MKTPEAPPLA PDCLPSDQAP APARLSRQAS PMDKNTDPEL MPTPRDGDDP PQVSSDPMVG
70 80 90 100 110 120
LALSQELEEG VPASLPTPLE SGFGSPSELS SRVEEKELSE NVSLPAEETN RPELGPGEDV
130 140 150 160 170 180
EGVSEELTPE DEGYTIWNYN FSQVPRFLSG SWSEFITQPE NFLKGCKWAP DGSCILTNSA
190 200 210 220 230 240
DNILRIYNLP PELYNEGEQL EYAEMAPVLR MVEGDTIYDY CWYSLMSSAQ PDTSYVASSS
250 260 270 280 290 300
RENPIHIWDA FTGELRASFR SYNHLDELTA AHSLCFSPDG SQLFCGFNRT VRVFSTSRPG
310 320 330 340 350 360
RDCEVRTTFA KRQGQSGIIS CIAFSPTQPL YACGSYGRSL GLYTWEDGSP LALLGGHQGG
370 380 390 400 410 420
ITHLCFHPDG NCFFSGARKD AELLCWDLRQ LGHPLWSLSR EVTTNQRIYF DLDPTGQFLV
430 440 450 460 470 480
SGSTSGAVSV WDTGGAGLES KPEPVLSFQP QKDCTNGVSL HPSLPLLATA SGQRVFPEPT
490 500 510 520 530
ESGDEREEEV DLPLLSMRHV HLECQLQLWW CGGGPDTSIS DAHQEEMGQG RTEGGGGEFT