Q3SLA9

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Thiobacillus denitrificans (strain ATCC 25259)
KEGG Pathway
tbd:Tbd_0553
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

396-466 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q3SLA9

Entry ID Method Resolution Chain Position Source
AF-Q3SLA9-F1 Predicted AlphaFoldDB

No variants for Q3SLA9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q3SLA9

No associated diseases with Q3SLA9

4 regional properties for Q3SLA9

Type Name Position InterPro Accession
domain DHHA1 domain 730 - 867 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 650 - 692 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 6 - 551 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 1 - 705 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKSSAIRQSF LDFFASKGHT VVPSSSLVPG NDPTLLFTNA GMVQFKDVFT GQDTRPYSRA
70 80 90 100 110 120
VSSQRCVRAG GKHNDLENVG YTARHHTFFE MLGNFSFGDY FKQDAIKYAW EYLTTVLKLP
130 140 150 160 170 180
SEKLWVTVYA EDDEAYDIWH NDVGVPKARI VRIGDNKGAR YASDNFWAMG DTGPCGPCTE
190 200 210 220 230 240
IFYDHGPDVA GGPPGSPDED GDRYIEIWNN VFMQFNRDEA GTMHPLPKPS VDTGMGLERI
250 260 270 280 290 300
SAVMQHVHSN YEIDLFQALI AAAARETNTH DLGNNSLKVI ADHIRACSFL IVDGVIPGNE
310 320 330 340 350 360
GRGYVLRRII RRAIRHGYKL GARAAFFHRI VPDLGIAMGE AYPELVKAQT RVMDILRQEE
370 380 390 400 410 420
ERFFETIEHG MGILESELKK LVAGGVFDGE LAFKLHDTYG FPLDLTADIC REAGVAVDTA
430 440 450 460 470 480
AFDAAMARQK AQARGAGKFK LGAGLDYAGE ATTFHGYDTL AREASVLALY KDGSAVGELK
490 500 510 520 530 540
EGDSGVVVLD HTPFYAESGG QVGDRGTLQS KQGAFEVEDT LKIQAQVFGH HGVVKTGSLA
550 560 570 580 590 600
VGDSVLARVD ETARARTMRN HSVTHLMHKA LREVLGEHVQ QKGSLVDSEK TRFDFVQPSP
610 620 630 640 650 660
MTAAQIREVE ARVNAEILVN TPTQARVMGI EDAQKTGAMM LFGEKYGDEV RVLDIGSSRE
670 680 690 700 710 720
LCGGTHVART GDIGLFKIVS ESGVAAGVRR VEAITGDNAL AYLQAREQEI QQAAAALKAH
730 740 750 760 770 780
PAELGAKLAQ TLDHVRALEK DLERLKSKLA ASAGDELVAQ AADINGVKVL AARLDGIDAK
790 800 810 820 830 840
GLRETADKLR DKLKSCALVL GTVADGKVSL IAAVTPDVTA KIKAGELVNV VAAQVGGKGG
850 860 870
GKPDLAMAGG TDPGALPAAL ASVEAWVQSR LS