Q3SK29

PR
Gene name
pheT
Protein name
Phenylalanine--tRNA ligase beta subunit
Names
Phenylalanyl-tRNA synthetase beta subunit, PheRS
Species
Thiobacillus denitrificans (strain ATCC 25259)
KEGG Pathway
tbd:Tbd_1012
EC number
6.1.1.20: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

447-518 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q3SK29

Entry ID Method Resolution Chain Position Source
AF-Q3SK29-F1 Predicted AlphaFoldDB

No variants for Q3SK29

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q3SK29

No associated diseases with Q3SK29

6 regional properties for Q3SK29

Type Name Position InterPro Accession
domain tRNA-binding domain 39 - 147 IPR002547
domain Ferrodoxin-fold anticodon-binding domain 687 - 780 IPR005121
domain B3/B4 tRNA-binding domain 211 - 384 IPR005146
domain tRNA synthetase, B5-domain 398 - 473 IPR005147
domain Phenylalanly tRNA synthetase, tRNA-binding-domain 45 - 146 IPR033714
domain Phenylalanyl tRNA synthetase beta chain, core domain 471 - 675 IPR041616

Functions

Description
EC Number 6.1.1.20 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
magnesium ion binding Binding to a magnesium (Mg) ion.
phenylalanine-tRNA ligase activity Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe).
tRNA binding Binding to a transfer RNA.

1 GO annotations of biological process

Name Definition
phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. The phenylalanyl-tRNA synthetase is a class-II synthetase. However, unlike other class II enzymes, The activated amino acid is transferred to the 2'-OH group of a phenylalanine-accepting tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQFSEAWLRK LVNPALDTTE LAHALTMAGL EVEALTAAAP PFNDVVVAEI LSAQKHPDAD
70 80 90 100 110 120
RLRVCQVDIG EAAPATIVCG APNAAAGLKV PCARPGAKLP GIEIKVAKVR GVESFGMLCS
130 140 150 160 170 180
TKELGLEGAA DGLMVLPDDA PVGEDLRGWL NLDDTLVTLK LTPNRADCLS LVGIAREVGA
190 200 210 220 230 240
ITGAEVRIPQ ASPVAPRIAD TVEVTVAASD ACSRYLGRVV RGIDAQATTP RWMAERLERG
250 260 270 280 290 300
GIRPLLAPID VTNYVLLELG QPMHAFALSR LSGGIEVRLA RAGETLALLS GQTVELSPDM
310 320 330 340 350 360
LVIADASGPV ALAGIMGGQA TSVERATVDV FLEAAFFAPA AIAGRARRLG LSTDSAHRFE
370 380 390 400 410 420
RGVDFGAIHA AMERATQLLL DICGGQPGPI SEVTGSLPRR EPIELRLSRL RRVAGVELGA
430 440 450 460 470 480
DQVIRDLAAL GCVVEQADER LVVTPPSFRF DLAIEEDLIE EAVRLFGYDR IPARPPAAPS
490 500 510 520 530 540
RMLAQDETRI ADDALRQKMV DLDYQEVITY SFVDPAGEQA LDPDVRLLTL ANPIASQLSV
550 560 570 580 590 600
MRTTLWGGLI ETLRHNLNRQ QERVRIFELG RVYASLAEQP RKLGGLAYGE ALPEQWGVPG
610 620 630 640 650 660
RRVDFFDVKG DLERLFGQPL DAGRGEHPAL HPGQSAALWV DGHRGGWIGA LHPRLVQAFD
670 680 690 700 710 720
LAAAPVLFEL DSEILARRAL PRHAGLSRFP QVRRDLAFVL DAGLAAGDLL AALREAAPAS
730 740 750 760 770 780
IRAIEVFDDY RGKGVDQNQK SLAIRVVMQD TERTLTDRDV DEAVQKLVDA AARRCSATLR
A