Q3MCT9

PR
Gene name
hemH
Protein name
Ferrochelatase
Names
Heme synthase, Protoheme ferro-lyase
Species
Trichormus variabilis (strain ATCC 29413 / PCC 7937) (Anabaena variabilis)
KEGG Pathway
ava:Ava_1574
EC number
4.98.1.1: Forming coordination complexes
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

27-108 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q3MCT9

Entry ID Method Resolution Chain Position Source
AF-Q3MCT9-F1 Predicted AlphaFoldDB

No variants for Q3MCT9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q3MCT9

No associated diseases with Q3MCT9

3 regional properties for Q3MCT9

Type Name Position InterPro Accession
active_site Ferrochelatase, active site 191 - 210 IPR019772
domain Ferrochelatase, C-terminal 170 - 305 IPR033644
domain Ferrochelatase, N-terminal 4 - 165 IPR033659

Functions

Description
EC Number 4.98.1.1 Forming coordination complexes
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
ferrochelatase activity Catalysis of the reaction: heme B (protoheme) + H+ = Fe(2+) + protoporphyrin IX.
metal ion binding Binding to a metal ion.

1 GO annotations of biological process

Name Definition
heme biosynthetic process The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGRVGVLLLN LGGPDKLEDV GPFLFNLFSD PEIIRLPFRW LQKPLAWFIA SRRTKTSQEN
70 80 90 100 110 120
YKQIGGGSPL RRITEAQGEA LKEQLHDLGQ EANIYVGMRY WHPYTEEAIA LLTQDNLDNL
130 140 150 160 170 180
VILPLYPQFS ISTSGSSFRL LERLWQEDPK LQRLDYTVIP SWYKEPCYLQ AMAELISQEV
190 200 210 220 230 240
DQFPDPDQVH VFFSAHGVPK SYVEEAGDPY QQEIEECTAL IMQTLNRPNP HTLAYQSRVG
250 260 270 280 290 300
PVEWLQPYTE DALKELGAQG VKDLVVVPIS FVSEHIETLQ EIDIEYREIA EEAGIHNFRR
310 320 330 340 350 360
VAAPNTHPVF IRALANLVID ALNKPSFKLS QAAQIKKMVK MYPPESWEWG MTSSAEVWNG
370 380
RIAMLGFIAL IIELVTGQGL LHMIGLLQ