Q3M3N7

PR
Gene name
queA
Protein name
S-adenosylmethionine:tRNA ribosyltransferase-isomerase
Names
Queuosine biosynthesis protein QueA
Species
Trichormus variabilis (strain ATCC 29413 / PCC 7937) (Anabaena variabilis)
KEGG Pathway
ava:Ava_4802
EC number
2.4.99.17: Transferring other glycosyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

16-89 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q3M3N7

Entry ID Method Resolution Chain Position Source
AF-Q3M3N7-F1 Predicted AlphaFoldDB

No variants for Q3M3N7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q3M3N7

No associated diseases with Q3M3N7

4 regional properties for Q3M3N7

Type Name Position InterPro Accession
domain PA domain 237 - 354 IPR003137
domain Transferrin receptor-like, dimerisation domain 647 - 758 IPR007365
domain Peptidase M28 397 - 585 IPR007484
domain Transferrin receptor protein 1/2, PA domain 211 - 386 IPR037324

Functions

Description
EC Number 2.4.99.17 Transferring other glycosyl groups
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

1 GO annotations of molecular function

Name Definition
S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity Catalysis of the reaction: S-adenosylmethionine + 7-(aminomethyl)-7-deazaguanosine-tRNA = adenine + methionine + epoxyqueuosine-tRNA. 7-(aminomethyl)-7-deazaguanosine-tRNA is also known as preQ1-tRNA, and epoxyqueuosine-tRNA as oQ-tRNA.

1 GO annotations of biological process

Name Definition
queuosine biosynthetic process The chemical reactions and pathways resulting in the formation of queuosines, a series of nucleosides found in tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKKQILQLNL EQTSSAAAED TNLDCSLAGY DYVLPPERIA QNPAVPRDSS RLLVVNSQTT
70 80 90 100 110 120
GKETPPLHQI FRDLPDILRP GDLLIMNNTK VIPARLYGRK SSGAEVEILL LEERKFNCWL
130 140 150 160 170 180
ALVKPGKRFK KGTQIIFEGL GIRNLGIKNS PHYPLSPEGF PPSPVPNPHQ LTATVLETDK
190 200 210 220 230 240
ATGGRLLQFD LPEGESLVQL LDKFGEIPLP PYITASQAAD EQYQTVYAEQ PGAIAAPTAG
250 260 270 280 290 300
LHFTPELLEK LRDRNINQAF ITLHVGVGTF RPVEVEDVAT HQMHEEWIEI PAATVAQIKA
310 320 330 340 350 360
TKAAGGRIIA VGTTVVRALE GAAASGDLQE FCGKTNLFIY PGYKWQVVEG LITNFHLPRS
370 380 390 400
SLLMLVSALI GRERLLNIYQ EAIASQYRFY SFGDAMLILP EARGVNSH