Q3K932

PR
Gene name
tpm
Protein name
Thiopurine S-methyltransferase
Names
Thiopurine methyltransferase
Species
Pseudomonas fluorescens (strain Pf0-1)
KEGG Pathway
pfo:Pfl01_3985
EC number
2.1.1.67: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

43-116 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q3K932

Entry ID Method Resolution Chain Position Source
AF-Q3K932-F1 Predicted AlphaFoldDB

No variants for Q3K932

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q3K932

No associated diseases with Q3K932

No regional properties for Q3K932

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q3K932

Functions

Description
EC Number 2.1.1.67 Methyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

1 GO annotations of molecular function

Name Definition
thiopurine S-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether.

2 GO annotations of biological process

Name Definition
methylation The process in which a methyl group is covalently attached to a molecule.
response to metal ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQPEFWHKKW ESNQIGFHQL EVNPYLQRHW PDLAIPVQAR VLVPLCGKSL DLLWLAGRGH
70 80 90 100 110 120
QVLGVELSEK AVEDFFHEQQ LQPQVSEQGD FKVYRADAVE LWCGDFFSLT MADVAGCTAL
130 140 150 160 170 180
YDRAAVIALP PAMRERYAAH LQSILPACRG LLVTLDYDQS QMPGPPFSVD DAEVQRLLGS
190 200 210
VWRVEMLEQQ DVLGDSWKFV QAGVTRLEER VYRIRGV