Q3K7C3

PR
Gene name
leuA
Protein name
2-isopropylmalate synthase
Names
Alpha-IPM synthase, Alpha-isopropylmalate synthase
Species
Pseudomonas fluorescens (strain Pf0-1)
KEGG Pathway
pfo:Pfl01_4594
EC number
2.3.3.13: Acyl groups converted into alkyl groups on transfer
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

423-498 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q3K7C3

Entry ID Method Resolution Chain Position Source
AF-Q3K7C3-F1 Predicted AlphaFoldDB

No variants for Q3K7C3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q3K7C3

No associated diseases with Q3K7C3

5 regional properties for Q3K7C3

Type Name Position InterPro Accession
domain Pyruvate carboxyltransferase 33 - 313 IPR000891
conserved_site Alpha-isopropylmalate/homocitrate synthase, conserved site 40 - 56 IPR002034-1
conserved_site Alpha-isopropylmalate/homocitrate synthase, conserved site 243 - 256 IPR002034-2
domain 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain 422 - 551 IPR013709
domain LeuA, N-terminal catalytic TIM barrel domain 32 - 315 IPR039371

Functions

Description
EC Number 2.3.3.13 Acyl groups converted into alkyl groups on transfer
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

1 GO annotations of molecular function

Name Definition
2-isopropylmalate synthase activity Catalysis of the reaction: 3-methyl-2-oxobutanoate + acetyl-CoA + H(2)O = (2S)-2-isopropylmalate + CoA + H(+).

1 GO annotations of biological process

Name Definition
leucine biosynthetic process The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSMLKDPSSK YRAFPVINLP DRTWPSKTID AAPIWCSSDL RDGNQSLIEP MDAVKKLRFW
70 80 90 100 110 120
KTLVQVGVKE IEASFPAASQ TDFDFVRTLI EDGHIPDDTT IQVLTQGRED LIERTFESLR
130 140 150 160 170 180
GAKKAIVHLY NATSPSFRRI VFNQDKDGIK AIAVNAAKLF VKYAAMQPDT EWTFEYSPET
190 200 210 220 230 240
FSATELEFAK EVCDAVIEVW NPTPEHKIIL NLPATVECAT PNVYADQIEW FHRNINRRDS
250 260 270 280 290 300
VIISLHTHND RGTGVAATEL GLMAGADRVE GCLFGNGERT GNVDLVTVAL NMYTQGINPD
310 320 330 340 350 360
LDFSDIDGVR KVVEECNQIQ VHPRHPYVGD LVHTAFSGSH QDAIRKGFAQ QKPDTLWEVP
370 380 390 400 410 420
YLPIDPADIG RSYEAVIRVN SQSGKGGIAY LLEQEYGISL PRRMQIEFSQ VVQRETDRLG
430 440 450 460 470 480
LEMTAQQIHA LLHSEYLQAN TPYALVSHRL QEENGNSAVE VEVASKGQGE TNLHWRGKGN
490 500 510 520 530 540
GALEALVAGL PIPVEIMDYN EHAIGAGTNA KAAAYIELRV NGERAVHGVG IDENITTASF
550
KALFSALNRS LSQPEAKAA