Q3JC50

PR
Gene name
valS
Protein name
Valine--tRNA ligase
Names
Valyl-tRNA synthetase, ValRS
Species
Nitrosococcus oceani (strain ATCC 19707 / BCRC 17464 / JCM 30415 / NCIMB 11848 / C-107)
KEGG Pathway
noc:Noc_1091
EC number
6.1.1.9: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

397-472 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q3JC50

Entry ID Method Resolution Chain Position Source
AF-Q3JC50-F1 Predicted AlphaFoldDB

No variants for Q3JC50

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q3JC50

No associated diseases with Q3JC50

5 regional properties for Q3JC50

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 40 - 51 IPR001412
domain Aminoacyl-tRNA synthetase, class Ia 14 - 599 IPR002300
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 649 - 799 IPR013155
domain Valyl-tRNA synthetase, tRNA-binding arm 862 - 922 IPR019499
domain Valyl tRNA synthetase, anticodon-binding domain 598 - 741 IPR033705

Functions

Description
EC Number 6.1.1.9 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
valine-tRNA ligase activity Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H(+).

1 GO annotations of biological process

Name Definition
valyl-tRNA aminoacylation The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. The valyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a valine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDKNYNPQAI EQYWYQIWEQ KGYFTPQGKD SSYCIMIPPP NVTGHLHMGH AFQSTIMDAL
70 80 90 100 110 120
IRYHRMRGDD TLWQVGADHA GIATQMVVEN QLNAEGKTRH DLGREAFIQR VWEWKEHSGG
130 140 150 160 170 180
TITRQLRRMG TSVDWSRERF TMDEGLSQAV GEVFVRLYDE GLLYRGKRLV NWDSVLHTAI
190 200 210 220 230 240
SDLEVISEEE NSHLWHMRYP LSDGSGHLVV ATTRPETMLG DTAVAVHPED PRYQHLIGKT
250 260 270 280 290 300
VALPLTDRTI PVIADDYVEP EFGSGCVKIT PAHDFNDYEV GQRHGLPFIN IFTVDASLNE
310 320 330 340 350 360
NVPERYRNLD RFEARKLVVA DLEAAGLLEK IEDHKLMVPR GDRSRTVIEP YLTDQWFVKT
370 380 390 400 410 420
APLAEPAIQA VENGQIRFIP ENWNKIYFEW MRNIQDWCIS RQIWWGHRIP AWYDPEGKIY
430 440 450 460 470 480
VAPTETQARQ KYNLPPDLPL EQDPDVLDTW FSSALWPFST LGWPEDTSLL RAFYPTSVLV
490 500 510 520 530 540
TGFDIIFFWV ARMIMMGLKF TGEVPFHEVY IHGLVRDAEG QKMSKSKGNV LDPLDLIDGI
550 560 570 580 590 600
DLETLVTKRT GGLMQPAMAK RIEKATRKEF PQGIPSFGCD ALRFTFAILA TRGRDIRFDL
610 620 630 640 650 660
GRIEGYRNFC NKLWNAARYV LINVSSEISV ERQGKPEQAE ENLMLGAPER WIISRFHSTT
670 680 690 700 710 720
QEVIEGIENY RFDRVAQAIY NFTWNEYCDW YLELSKPVLN NPASPEAAKR RTRHTLVHVL
730 740 750 760 770 780
EALLRLAHPI IPFITEEIWQ QVGPLAGRQG KTIMLQPYPQ PEIDKIDEDA VAEIEWVIAF
790 800 810 820 830 840
VTGVRSIRSQ MNIAPGKPIP LLLQAGKAHD RTRLESNQKF LAALAKLDSI QWLKDETPPP
850 860 870 880 890 900
AATALVDELK LLIPLAGLID KEAELKRLDR EMQRMRKDLA RVQGKLANSN YVERAPAEIV
910 920
AKERQRAQEV TAALSTLEQQ HAEITDLNP