Q3JC02

PR
Gene name
thrS
Protein name
Threonine--tRNA ligase
Names
Threonyl-tRNA synthetase, ThrRS
Species
Nitrosococcus oceani (strain ATCC 19707 / BCRC 17464 / JCM 30415 / NCIMB 11848 / C-107)
KEGG Pathway
noc:Noc_1140
EC number
6.1.1.3: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

99-170 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q3JC02

Entry ID Method Resolution Chain Position Source
AF-Q3JC02-F1 Predicted AlphaFoldDB

No variants for Q3JC02

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q3JC02

No associated diseases with Q3JC02

7 regional properties for Q3JC02

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 323 - 530 IPR002314
domain TGS 1 - 61 IPR004095
domain Anticodon-binding 542 - 629 IPR004154
domain Aminoacyl-tRNA synthetase, class II 244 - 535 IPR006195
domain Threonyl/alanyl tRNA synthetase, SAD 169 - 218 IPR012947
domain Threonine-tRNA ligase catalytic core domain 242 - 540 IPR033728
domain Threonine-tRNA ligase, class IIa, anticodon-binding domain 540 - 629 IPR047246

Functions

Description
EC Number 6.1.1.3 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
threonine-tRNA ligase activity Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).
tRNA binding Binding to a transfer RNA.

1 GO annotations of biological process

Name Definition
threonyl-tRNA aminoacylation The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. The threonyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a threonine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPVITLPDGS QRSFDHPVTV YDVAADIGPG LAKAALGGKI EGRLVDSSYP LEKDTKLTII
70 80 90 100 110 120
TERDMDGLEI IRHSCAHLLA QAVKALYPEA QVTIGPVIED GFYYDFAYPK GFTPEDLEAI
130 140 150 160 170 180
EAKMRELVEQ DLSVHRELKS REEAVSLFRR MGEEYKAEII ASIPSEEEIS LYRQGDFVDL
190 200 210 220 230 240
CRGPHVPSTA RLKAFKLTKV AGAYWRGDAN NEMLQRIYGT AWPDKKALKA YLHRLEEAEK
250 260 270 280 290 300
RDHRRIGADL DLFSIQEEAG GGLVFWHPMG ARIRRVIEDF WQERHTAAGY EMLYTPHIAH
310 320 330 340 350 360
EELWQTSGHT DFYRESMYQP MEDDHQLYQL KPMNCPFHVL IYQGRLRSYR ELPIRWAELG
370 380 390 400 410 420
TVYRHEMSGA LHGLMRVRGF TQDDAHIFCR EEQIENEILG ILDLTLEMLA AFGFDRYEID
430 440 450 460 470 480
LSTRPEKSVG PEAIWEQATQ ALRSALDKKG LDYAVDEGGG AFYGPKIDIK IEDAIGRKWQ
490 500 510 520 530 540
CSTVQLDFNL PERFAMEYVA EDGARHRPIM IHRAVLGSLE RFFGVLIEHY EGKFPPWLAP
550 560 570 580 590 600
VQVVVMSITD RQEGYARQVE EAMRNKGFRS LLDLRNEKIG FKIREHILRR IPYLLVIGDR
610 620 630 640
EVANQTVAVR TRYSQDLGAM SLDAFMEHLS VDVARLGHNI SEED