Q3ILQ9

PR
Gene name
cysG
Protein name
Siroheme synthase
Names
Species
Pseudoalteromonas translucida (strain TAC 125)
KEGG Pathway
pha:PSHAa0213
EC number
1.3.1.76: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

163-234 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q3ILQ9

Entry ID Method Resolution Chain Position Source
AF-Q3ILQ9-F1 Predicted AlphaFoldDB

No variants for Q3ILQ9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q3ILQ9

No associated diseases with Q3ILQ9

2 regional properties for Q3ILQ9

Type Name Position InterPro Accession
domain Cysteinyl-tRNA synthetase, class Ia, DALR 353 - 422 IPR015273
domain tRNA synthetases class I, catalytic domain 2 - 312 IPR032678

Functions

Description
EC Number 1.3.1.76 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
NAD binding Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.
precorrin-2 dehydrogenase activity Catalysis of the reaction: NAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin.
sirohydrochlorin ferrochelatase activity Catalysis of the reaction: siroheme + 2 H+ = Fe(2+) + sirohydrochlorin.
uroporphyrin-III C-methyltransferase activity Catalysis of the reaction: 2 S-adenosyl-L-methionine + uroporphyrin III = 2 S-adenosyl-L-homocysteine + precorrin-2.

3 GO annotations of biological process

Name Definition
cobalamin biosynthetic process The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
methylation The process in which a methyl group is covalently attached to a molecule.
siroheme biosynthetic process The chemical reactions and pathways resulting in the formation of siroheme, a tetrahydroporphyrin with adjacent, reduced pyrrole rings.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQYLPIFTKL DNKPVLVVGG GDVALRKCSA LLKARASITL VAPKFCQQLI ELASENKVTL
70 80 90 100 110 120
IHEYFSEQHL KNMMLVIAAT DLEHVNSQVF ELANAHNIFV NVVDDQPKCT FIFPSIVDRN
130 140 150 160 170 180
PITIAISSAG TAPVLARRLR EKLETLIPQH IGPLATLVGG FRSKVKQRFK HFADRRQFWE
190 200 210 220 230 240
GVFDSSVVSK VQTGDTQAAE QQLEHMLNAK AEPEGEVYVV GAGPGDPELL TLKALQLMQQ
250 260 270 280 290 300
ADVVVYDYLV SDEIMELVRR DADLICVGKR LGDHSVAQQD TNQMLVDLAK QGKKVCRIKG
310 320 330 340 350 360
GDPFIYGRGG EEVQVLAANK VNYQIVPGIT AAAGCSAYAG IPLTHRDHAQ AIQFVTGHCK
370 380 390 400 410 420
KDGQELDWQS LAKPNQTLAI YMGVIKSPHI QAELLKHGRN ANTPVAIIEN GTRKNQRVIT
430 440 450 460 470
GKLGELADLI TRNSVVSPAL LIIGEVASLH QELHWFGAKA QTSSFAQPLT DVA