AiPD: Autoinhibited Protein Database

Gene name	ICU11
Protein name	2-oxoglutarate and iron-dependent oxygenase domain-containing protein ICU11
Names	Protein INCURVATA 11
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT1G22950
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-89 (Predicted disordered autoinhibitory region) PR

1-89 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q3ED68-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
ENSVATH04626802	19	P>L	No	1000Genomes
tmp_1_8127095_T_C	25	Q>R	No	1000Genomes
tmp_1_8127062_G_T	36	A>E	No	1000Genomes
ENSVATH04626801	37	R>K	No	1000Genomes
ENSVATH04626800	60	Y>N	No	1000Genomes
ENSVATH00038699	62	P>A	No	1000Genomes
ENSVATH04626799	67	S>F	No	1000Genomes
ENSVATH11836183	104	V>G	No	1000Genomes
ENSVATH00038698	104	V>I	No	1000Genomes
tmp_1_8126750_C_T	112	D>N	No	1000Genomes
ENSVATH04626787	131	S>G	No	1000Genomes
ENSVATH04626786	131	S>T	No	1000Genomes
ENSVATH11836181	153	S>T	No	1000Genomes
tmp_1_8126529_A_G	155	V>A	No	1000Genomes
tmp_1_8126497_T_G,A	166	M>L	No	1000Genomes
tmp_1_8126476_C_G	173	E>Q	No	1000Genomes
tmp_1_8126271_T_A	213	S>C	No	1000Genomes
tmp_1_8126237_C_T	224	S>N	No	1000Genomes
tmp_1_8126133_A_C	229	V>G	No	1000Genomes
ENSVATH11836126	295	D>N	No	1000Genomes
ENSVATH13948416	345	M>T	No	1000Genomes
ENSVATH04626766	391	A>D	No	1000Genomes
ENSVATH01090678	393	K>N	No	1000Genomes

Type	Name	Position	InterPro Accession
domain	Oxoglutarate/iron-dependent dioxygenase	238 - 339	IPR005123
domain	Prolyl 4-hydroxylase, alpha subunit	159 - 338	IPR006620

		Description
EC Number
Subcellular Localization	Nucleus, nucleoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

Name	Definition
dioxygenase activity	Catalysis of an oxidation-reduction (redox) reaction in which both atoms of oxygen from one molecule of O2 are incorporated into the (reduced) product(s) of the reaction. The two atoms of oxygen may be distributed between two different products. [DOI:10.1016/S0040-4020(03)00944-X, GOC:bf]
iron ion binding	Binding to an iron (Fe) ion.
L-ascorbic acid binding	Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species.
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor.

Name	Definition
histone methylation	The modification of histones by addition of methyl groups.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P24802	PLOD1	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	Gallus gallus (Chicken)	PR
O60568	PLOD3	Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3	Homo sapiens (Human)	PR
Q20679	let-268	Multifunctional procollagen lysine hydroxylase and glycosyltransferase	Caenorhabditis elegans	PR